DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chico and irs1

DIOPT Version :9

Sequence 1:	NP_001188772.1	Gene:	chico / 64880	FlyBaseID:	FBgn0024248	Length:	968	Species:	Drosophila melanogaster
Sequence 2:	XP_687702.4	Gene:	irs1 / 559281	ZFINID:	ZDB-GENE-030131-872	Length:	1099	Species:	Danio rerio

Alignment Length:	1045	Identity:	241/1045 - (23%)
Similarity:	400/1045 - (38%)	Gaps:	268/1045 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GYLKKLKTMKKKFFVLYEETSTSAARLEYYDTEKKFLQRA-EPKRVIYLKNCFNINRRLDTKHRF 76
            |||:|.|:|.|:||||...:::..:|||||:.|||:..:: .|||.|.|::|||||:|.|:|::.
Zfish    18 GYLRKPKSMHKRFFVLRAASASGPSRLEYYENEKKWRHKSGAPKRSIPLESCFNINKRADSKNKH 82

  Fly    77 VIVLSSRDGGFGIVLENENDLRKWLDKLLVLQ-----------RNIANSN---GTAHSPYDHVWQ 127
            ::.|.::|..|.|..::|.:...|.:.|:.|.           |.:...|   .|....:..|||
Zfish    83 LVALYTKDEYFAIAADSEIEQESWYEALVDLHNRGKVHETAPGRGVGEDNYGEATPGPAFKEVWQ 147

  Fly   128 VVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVASIEILLTTIRRCGHASPQCI 192
            |:::.||:.....:.|.|..|||:|:::||.:..:        .|::.:.|..||||||:  :..
Zfish   148 VILKPKGLGHTKNLIGVYRLCLTNKTISFVKLNSD--------AAAVVLQLMNIRRCGHS--ENF 202

  Fly   193 FYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTNLINVYQNRPDLSHEPMRKR 257
            |::|:||.:|.|.|:.||:.|::.:|.|||.|||.||.|.:|         :.||       |.:
Zfish   203 FFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMKAMSE---------EFRP-------RSK 251

  Fly   258 SSSANEASKPINVNVIQNSQNSLELRSCSSPHNYGFG-RERCDSL----PTRNGTLSESSNQTYF 317
            |.|::..|.||:|.|.::..|:      ..|...|.| |.|.:|:    |.|.|..|.|......
Zfish   252 SQSSSNCSNPISVPVRRHHHNN------PPPSQVGLGRRSRAESVTATSPVRPGKHSHSFRVRAS 310

  Fly   318 GSNHGLRSNTIS--------------------GIRPHSTNKHSNS-PTFTMPLRCSESEESSISV 361
            ....|..|...|                    |.|.|....||.| ||.|.  |||.|..|.||:
Zfish   311 SDGEGTMSRPASVDGSPSSPSNARPQSQRHRGGSRLHPPLNHSRSIPTPTS--RCSPSAISPISL 373

  Fly   362 DESDDNGSFSHYRLNTRSSETAIPEENIDDFASAELFSKVTEQN-VSDENYIPMNPVNPTDAIHE 425
            ..|..:|..|       :|:...|..     :||.:....::.. :|.:.|    ..:|.|.
Zfish   374 SSSSTSGHGS-------TSDCLFPRR-----SSASISGSPSDGGFISSDEY----GSSPCDF--- 419

  Fly   426 KEKADMQRLEDASLHFNFPEHASEKLAKDFDLDSDNQCC--RPIRAYSIGNKVEHLKFNKRLGHL 488
              ::..:.:...||....|....|         .:|..|  :|                   |.|
Zfish   420 --RSSFRSVTPDSLGHTPPAREEE---------INNYICMAKP-------------------GSL 454

  Fly   489 NDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVEDNK---------HEFTANRSQSSITKEGTSYG 544
            ...|   ::.|:.|.|:.|::...:|::......:.         |:.|.::|.::..:|.|...
Zfish   455 PGAG---SQSRSQSRGTPSRLEEPELEKCFRKRTHSSGASPPTPCHQKTPSQSPAASLEEYTVMM 516

  Fly   545 SSANRQKKSTSA---------PLLSLKNQINSDRMSDLMEIDFSQATNLEKQKFIKNNEIPKYIE 600
            .:..|.:.::|:         |..|...:          ..|.|||.: |:....|::.....:.
Zfish   517 PTYPRSRSASSSSSTYRHSFMPTHSYPEE----------GTDASQAKD-ERGPDHKDDGYMPMLP 570

  Fly   601 NVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNT---AITSEDGYLEMKPVG-------------- 648
            .|.|..|.|.||...  ..|.|.:....::.|.   :....:||:.|.|.|
Zfish   571 GVAPATPTTKSSDYM--PMSPKSVSAPQQIINPRQHSHVDSNGYMMMSPSGSCSPDGTTNYGKIW 633

  Fly   649 -NGYTPSSNCLPMKVEKLKLSDYQTAPPL---TATAAPVHDLNKISTYNISAEKWREQPSR---- 705
             ||..|..:...|:.:.....||....|.   |.:..|....|.:           |.|.|
Zfish   634 TNGINPKLSVESMEGKVSSCGDYINMSPASCSTTSTPPDCFFNPV-----------EDPPRPMYA 687

  Fly   706 ----------SEEKKSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHLA 760
                      :..|:..|||..:..||:....:|:|.|   .|::.:..:....||:.|......
Zfish   688 YYSLPRSFKHANRKQDQSPLRVSLGSSRLAYADSSSSS---ASSDSLGGQSNSQQSAVKPKRSEG 749

  Fly   761 D-KIVENNNLDIGGHEEKKLVHSISSE---------DYTQIKDKSNDFTKFNEAGYKILQIKSDS 815
            : ::.....|.:...:...|..:..|.         :|..|        :||:..:       .:
Zfish   750 NGRLTRPTRLSLDASKASTLPRTRESPFPPEPKSPGEYVNI--------EFNDKAF-------SA 799

  Fly   816 SLISSKLYQKGIHKDNLERSQRLTESVNTIPDNATATAVSSSSLTKFNINSAKPAAAADSRSTGT 880
            ||.|                  |...|.::.|....:.:|||......:.|......::.:::.:
Zfish   800 SLAS------------------LFPPVYSVSDAEAPSDLSSSEYMNMQLGSQARRLCSELQTSSS 846

  Fly   881 DPS----TPQNILQIKDLNFPSRSSSRISQPELHYASLDLPHCSGQNPAKYL----KRGSRESPP 937
            ...    ||.|.:....|  |..|..     |..|.|:.|..|:|....:.:    .....::||
Zfish   847 SSDYAIITPSNSVSSPPL--PCESIC-----ERDYISMQLASCTGFPDTQLMLMTEALPDADAPP 904

  Fly   938 VSACP 942
            .|..|
Zfish   905 CSVSP 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_001188772.1	PH_IRS	7..112	CDD:269959	41/110 (37%)
		PH	25..104	CDD:278594	31/79 (39%)
		PTB_IRS	122..235	CDD:269915	42/112 (38%)
irs1	XP_687702.4	PH_IRS	12..118	CDD:269959	40/99 (40%)
		PH	14..113	CDD:278594	39/94 (41%)
		PTB_IRS	142..245	CDD:269915	43/121 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586783
Domainoid	1	1.000	94	1.000	Domainoid score	I7398
eggNOG	1	0.900	-	-		E1_28N3R
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001178
OrthoInspector	1	1.000	-	-		otm24799
orthoMCL	1	0.900	-	-		OOG6_105771
Panther	1	1.100	-	-	O	PTHR10614
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4611
SonicParanoid	1	1.000	-	-		X1499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820