Protein Alignment chico and IRS1

DIOPT Version :10

• Sequence 1: NP_723540.1
• Gene: chico / 64880
• FlyBaseID: FBgn0024248
• Length: 968
• Species: Drosophila melanogaster
• Sequence 2: NP_005535.1
• Gene: IRS1 / 3667
• HGNCID: 6125
• Length: 1242
• Species: Homo sapiens
• Alignment Length: 1082
• Identity: 246/1082 - (22%)
• Similarity: 401/1082 - (37%)
• Gaps: 330/1082 - (30%)

  Fly    13 GYLKKLKTMKKKFFVLYEETSTSA-ARLEYYDTEKKFLQRAE-PKRVIYLKNCFNINRRLDTKHR 75
            |||:|.|:|.|:||||...:.... ||||||:.|||:..::. |||.|.|::|||||:|.|:|::
Human    17 GYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNK 81

  Fly    76 FVIVLSSRDGGFGIVLENENDLRKWLDKLLVLQR-------------------NIANSNGTAHSP 121
            .::.|.:||..|.|..::|.:...|...||.|..                   :.:.|:|...:.
Human    82 HLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAG 146

  Fly   122 YD-------------HVWQVVIQKKGISEKVGITGTYHCCLTSKSLTFVCIGPEKTPNGEDRVAS 173
            .|             .||||:::.||:.:...:.|.|..|||||:::||.:..|        .|:
Human   147 EDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSE--------AAA 203

  Fly   174 IEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATNMHNTILSAMSAKTESNTN 238
            :.:.|..||||||:  :..|::|:||.:|.|.|:.||:.|::.:|.|||.|||.||.|.::
Human   204 VVLQLMNIRRCGHS--ENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSD---- 262

  Fly   239 LINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQN-------SQNSLELRS------CSSPHN 290
                 :.||       |.:|.|::..|.||:|.:.::       ||..|..||      .:||.:
Human   263 -----EFRP-------RSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPAS 315

  Fly   291 Y-----GFGRERCDSLPTRNGTLSE-----------SSNQTYFGSNHGLRSNTISGIRPHSTNKH 339
            .     |..|.|..|  ...||:|.           |:|:|:...:.|       ..|.|....|
Human   316 MVGGKPGSFRVRASS--DGEGTMSRPASVDGSPVSPSTNRTHAHRHRG-------SARLHPPLNH 371

  Fly   340 SNSPTFTMPL-RCSESEESSISVDES--DDNGSFSHYRLNTRSSETAIPEENIDDFASAELFSKV 401
            |.|  ..||. |||.|..|.:|:..|  ..:||.|......|||.:.....:...|.|::.:..
Human   372 SRS--IPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGGFISSDEYGS- 433

  Fly   402 TEQNVSDENYIPMNPVNPTDAIHEKEKADMQRLEDASLHFNFPEHASEKLAKDFDLDSDNQCCRP 466
                            :|.|.     ::..:.:...||....|....|:|:        |..|
Human   434 ----------------SPCDF-----RSSFRSVTPDSLGHTPPARGEEELS--------NYIC-- 467

  Fly   467 IRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVRAYSVGSKSKIPRCDLQRVVLVEDNKHEFTANR 531
                              :|     |:.|:                     .|...|.|...:..
Human   468 ------------------MG-----GKGPS---------------------TLTAPNGHYILSRG 488

  Fly   532 SQSSITKEGTSYGSSA--------------NRQKKST----SAPLLSLKNQINSDRMSDLMEIDF 578
            ........||..|:|.              ||.:|.|    ::|.::.:...:...::.:.|  :
Human   489 GNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTPSQSSVASIEE--Y 551

  Fly   579 SQATNLEKQKFIKNNEIPKYIENVFPKAPRTDSSSLTLHATSQKDIFNGTKLNNTAITSEDGYLE 643
            ::..............:|.:..:.|..........|.:|...::.  ...:.:::.:.::|||:.
Human   552 TEMMPAYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRG--GHHRPDSSTLHTDDGYMP 614

  Fly   644 MK----PVGNGYTPSSNCLPMKVEKLKLSDYQTAPPLTATAAPVHDLNKISTYNISAEKWREQPS 704
            |.    ||.:|...|.:.:||..:              :.:||...:|.|          |..|.
Human   615 MSPGVAPVPSGRKGSGDYMPMSPK--------------SVSAPQQIINPI----------RRHPQ 655

  Fly   705 RSEEK----KSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHLADKIVE 765
            |.:..    .|.|..........|::  |:|.|:.|.|....                  .|:..
Human   656 RVDPNGYMMMSPSGGCSPDIGGGPSS--SSSSSNAVPSGTSY------------------GKLWT 700

  Fly   766 NNNLDIGGHEEKKLVHSISSEDYT--QIKDKSNDFTKFNEAGYKILQIKSDSSLISSKLY--QKG 826
            |.   :|||....|.|.....:.:  ::...:.|:...:..|      .|::|..|...|  :..
Human   701 NG---VGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVG------DSNTSSPSDCYYGPEDP 756

  Fly   827 IHKD-----NLERSQRLTESVNTIPDNA----------------TATAVSSSSLTKFNINSAKPA 870
            .||.     :|.||.:.|:......:.|                .|||..|||.|
Human   757 QHKPVLSYYSLPRSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSST---------- 811

  Fly   871 AAADSRSTG-----TDPSTPQNILQIKDLNFP------SRSSSRISQPELHYASLDLPHCSGQNP 924
             ::||...|     .:||.|....|:...:.|      ::::||:::|    ..|.|    |...
Human   812 -SSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARP----TRLSL----GDPK 867

  Fly   925 AKYLKRGSRES--------PPVSACPEDGNTYAKIDF--DQS 956
            |..|.|...:.        ||.   |:....|..|:|  |||
Human   868 ASTLPRAREQQQQQQPLLHPPE---PKSPGEYVNIEFGSDQS 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
chico	NP_723540.1	PH_IRS	7..112	CDD:269959	43/119 (36%)
		PTB_IRS	122..235	CDD:269915	45/125 (36%)
IRS1	NP_005535.1	Mediates interaction with PHIP. /evidence=ECO:0000250	3..137		43/119 (36%)
		PH_IRS	11..118	CDD:269959	43/100 (43%)
		PTB_IRS	160..263	CDD:269915	44/121 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..430		49/194 (25%)
		YXXM motif 1	465..468		1/22 (5%)
		YXXM motif 2	551..554		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	592..616		3/25 (12%)
		YXXM motif 3	612..615		1/2 (50%)
		YXXM motif 4	632..635		0/2 (0%)
		YXXM motif 5	662..665		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	668..693		7/26 (27%)
		YXXM motif 6	732..735		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	771..900		30/150 (20%)
		GRB2-binding. /evidence=ECO:0000250	896..898		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..937
		YXXM motif 7	941..944
		YXXM motif 8	989..992
		YXXM motif 9	1012..1015
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1057..1146
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1190..1242