DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GALNT11 and Pgant5

DIOPT Version :9

Sequence 1:	NP_001358393.1	Gene:	GALNT11 / 63917	HGNCID:	19875	Length:	667	Species:	Homo sapiens
Sequence 2:	NP_001036338.1	Gene:	Pgant5 / 326151	FlyBaseID:	FBgn0031681	Length:	630	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	223/507 - (43%)
Similarity:	319/507 - (62%)	Gaps:	41/507 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    63 PSRVLEPQFKANKIDDVIDSRVEDPEEGH-LKFSSELGMIFNERDQELRDLGYQKHAFNMLISDR 126
            ||.||:..|.|..:.   :::.:..|.|. :|..:::..:..|:        ::::.||:|.||.
  Fly   109 PSVVLKKWFLAPSVQ---EAKGKPGEMGKPVKIPADMKDLMKEK--------FKENQFNLLASDM 162

Human   127 LGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDD 191
            :..:|.:.|.|:..|:.|.|...||..|:||.|:|||::.|||||.|||:|:|..||.|||||||
  Fly   163 ISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDD 227

Human   192 DSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQ 256
            .|:.|.|..:|:|||.| ||.|..|:|..||.||||.|::||.|.:|||:.|||:|||....||:
  Fly   228 ASERDFLGKQLEEYVAK-LPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLE 291

Human   257 PLLAAIREDRHTVVCPVIDIISADTLAY-SSSPVVRGGFNWGLHFKWDLVPLSELGRAEG-ATAP 319
            ||||.|.::|.|||||:||:||.:|..| ::|....|||||.|:|:|..||..|:.|... .|||
  Fly   292 PLLARIVQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAP 356

Human   320 IKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRR 384
            :::||||||||::::.||:|:|.||.|||||||||||:|||:|||||.|.|.|||||||:|||..
  Fly   357 LRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRVWMCGGVLEIAPCSRVGHVFRKST 421

Human   385 PYGSPEG-QDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYL 448
            ||..|.| .:.:.||:.||..||||::||.|:|..|..:..|.|::|:|..||.:|.||||:|||
  Fly   422 PYTFPGGTTEIVNHNNARLVEVWLDDWKEFYYSFYPGARKASAGDVSDRKALRDRLKCKSFRWYL 486

Human   449 DNVYPEMQISGSHAKPQQPIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRP-SQKGGLVVLKAC 512
            :|||||..:      |....::            |.:.:.:|..||...||. ::|.|   :..|
  Fly   487 ENVYPESLM------PLDYYYL------------GEIRNAETETCLDTMGRKYNEKVG---ISYC 530

Human   513 DYSDPNQIWIYNEEHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTF 564
            .....||::.|.:..: :::..||||.|.  |:.|..:::||..||:|:|.:
  Fly   531 HGLGGNQVFAYTKRQQ-IMSDDLCLDASS--SNGPVNMVRCHNMGGNQEWVY 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		65/110 (59%)
		pp-GalNAc-T	154..452	CDD:133004	170/300 (57%)
		Catalytic subdomain B	319..381		43/61 (70%)
		Ricin_B_lectin	483..>564	CDD:366226	25/81 (31%)
Pgant5	NP_001036338.1	pp-GalNAc-T	190..490	CDD:133004	170/300 (57%)
Pgant5	NP_001036338.1	Ricin_B_lectin	503..619	CDD:395527	25/83 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750