DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN9A and Scn9a

DIOPT Version :9

Sequence 1:	NP_001352465.1	Gene:	SCN9A / 6335	HGNCID:	10597	Length:	1988	Species:	Homo sapiens
Sequence 2:	NP_579823.1	Gene:	Scn9a / 78956	RGDID:	69368	Length:	1984	Species:	Rattus norvegicus

Alignment Length:	1988	Identity:	1849/1988 - (93%)
Similarity:	1916/1988 - (96%)	Gaps:	4/1988 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLPFIYGD 65
            |||||||||||||||||||||||||||:|.|:||.|:|||||:||.|||||||||||||||||||
  Rat     1 MAMLPPPGPQSFVHFTKQSLALIEQRISEEKAKEHKDEKKDDEEEGPKPSSDLEAGKQLPFIYGD 65

Human    66 IPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSLFSM 130
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
  Rat    66 IPPGMVSEPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYMLSPFSPLRRISIKILVHSLFSM 130

Human   131 LIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVV 195
            ||||||||||||||::|||:||||||||||||||||||:||||||||||||||||||||||||||
  Rat   131 LIMCTILTNCIFMTLSNPPEWTKNVEYTFTGIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVV 195

Human   196 IVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 IVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFA 260

Human   261 LIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCP 325
            |||||||||||||||||..||.||||||||||.||||:.:|||||||||||||||||||||||||
  Rat   261 LIGLQLFMGNLKHKCFRKELEENETLESIMNTAESEEELKKYFYYLEGSKDALLCGFSTDSGQCP 325

Human   326 EGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGS 390
            |||.|||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 EGYICVKAGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGS 390

Human   391 FYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRI 455
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||.||||
  Rat   391 FYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEFTSIGRSRI 455

Human   456 MGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEG 520
            |||||||||||:||||||||||||||||.| |:||||||||.||||||.||:|||:|||||||||
  Rat   456 MGLSESSSETSRLSSKSAKERRNRRKKKKQ-KMSSGEEKGDDEKLSKSGSEESIRKKSFHLGVEG 519

Human   521 HRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRR 585
            |.|..||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
  Rat   520 HHRTREKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRR 584

Human   586 GSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEVII 650
            |||||||||:|||||||||||||||:||||||||||||||||||||||.||||||||||||||||
  Rat   585 GSLFVPHRPRERRSSNISQASRSPPVLPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVII 649

Human   651 DKATSDDSGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWY 715
            |||||||||||||:.|||..|||.|||||||||:|||||||||||||||||||||||||||||||
  Rat   650 DKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPPWWY 714

Human   716 RFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGN 780
            ||||.|||||||||||||||.|||||||||||||||||||||||||||||||||||||||||:||
  Rat   715 RFAHTFLIWNCSPYWIKFKKLIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAVGN 779

Human   781 LVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKL 845
            |:||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
  Rat   780 LIFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLIELFLADVEGLSVLRSFRLLRVFKL 844

Human   846 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHM 910
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.||.||||||
  Rat   845 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHM 909

Human   911 NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDN 975
            |||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||
  Rat   910 NDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDN 974

Human   976 LTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYISN 1040
            |||||||.|||||||||.|||:|||||||||||||||:||||||.|::.::..|.|.||||||||
  Rat   975 LTAIEEDTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKGSKDTKRTADPNNKKENYISN 1039

Human  1041 HTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEE 1105
            .|||||||.||||||||:|||:|||:||..|:::|.|||||||||||||||||||||||.||.||
  Rat  1040 RTLAEMSKDHNFLKEKDRISGYGSSLDKSFMDENDYQSFIHNPSLTVTVPIAPGESDLEIMNTEE 1104

Human  1106 LSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTDGCVWRFSCCQVNI 1170
            |||||||:|||.:.|||||||||||||||||| |||||||:|:||||||||||||.||.|||||:
  Rat  1105 LSSDSDSDYSKEKRNRSSSSECSTVDNPLPGE-EEAEAEPVNADEPEACFTDGCVRRFPCCQVNV 1168

Human  1171 ESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTY 1235
            :|||||:||.||||||:||||||||||||||||||||||||||||||:|||||||||||||||||
  Rat  1169 DSGKGKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTY 1233

Human  1236 IFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRA 1300
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1234 IFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRA 1298

Human  1301 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVP 1365
            ||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||.|||.
  Rat  1299 LSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTDGSRFPTSQVA 1363

Human  1366 NRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYS 1430
            ||||||||||||.||||||||||||||||||||||||||||||..|||||||||||::|||||||
  Rat  1364 NRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNEQPKYEYS 1428

Human  1431 LYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1495
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1429 LYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQK 1493

Human  1496 PIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTG 1560
            ||||||||.|||||||||||||||:|||||||||||||||||||:::|..||:|||:||||||||
  Rat  1494 PIPRPGNKFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTEYMDYVLHWINMVFIILFTG 1558

Human  1561 ECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVK 1625
            |||||||||||||||||||||||||||:||||||||::||.||||||||||||||||||||||:|
  Rat  1559 ECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIK 1623

Human  1626 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMIC 1690
            |||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||
  Rat  1624 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMIC 1688

Human  1691 LFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMY 1755
            ||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat  1689 LFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMY 1753

Human  1756 IAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNK 1820
            ||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
  Rat  1754 IAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNK 1818

Human  1821 VQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLK 1885
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||
  Rat  1819 VQLIAMDLPMVSGDRIHCLDILFAFTKRVLGEGGEMDSLRSQMEERFMSANPSKVSYEPITTTLK 1883

Human  1886 RKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATS 1950
            ||||:||||:||||||||||||:||||||||||||||||||.||:|..||||||||||||||.|:
  Rat  1884 RKQEEVSATIIQRAYRRYRLRQHVKNISSIYIKDGDRDDDLPNKEDTVFDNVNENSSPEKTDVTA 1948

Human  1951 STTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDSKESKK 1988
            ||.||||||||||||:||||.|:||||||.||  ||:|
  Rat  1949 STISPPSYDSVTKPDQEKYETDKTEKEDKEKD--ESRK 1984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCN9A	NP_001352465.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..55		21/28 (75%)
		I. /evidence=ECO:0000305	112..410		284/297 (96%)
		Ion_trans	125..410	CDD:306908	271/284 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..543		70/81 (86%)
		Na_trans_cytopl	488..681	CDD:314757	175/192 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..611		44/45 (98%)
		II. /evidence=ECO:0000305	726..989		254/262 (97%)
		Ion_trans	743..956	CDD:306908	206/212 (97%)
		Na_trans_assoc	982..1187	CDD:310839	164/204 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1102..1148		38/45 (84%)
		III. /evidence=ECO:0000305	1180..1488		294/307 (96%)
		Ion_trans	1191..1466	CDD:306908	263/274 (96%)
		Na_channel_gate	1458..1510	CDD:240441	50/51 (98%)
		IV. /evidence=ECO:0000305	1497..1795		281/297 (95%)
		Ion_trans	1514..1770	CDD:306908	240/255 (94%)
		GPHH	1774..1837	CDD:318993	61/62 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1934..1988		44/53 (83%)
Scn9a	NP_579823.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..55		21/28 (75%)
		I. /evidence=ECO:0000305	112..410		284/297 (96%)
		Ion_trans	147..410	CDD:278921	251/262 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..542		70/81 (86%)
		Na_trans_cytopl	487..606	CDD:288761	108/118 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..609		31/32 (97%)
		II. /evidence=ECO:0000305	725..988		254/262 (97%)
		Ion_trans	760..955	CDD:278921	188/194 (97%)
		Na_trans_assoc	981..1185	CDD:284034	164/204 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1040		14/24 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1145		37/42 (88%)
		III. /evidence=ECO:0000305	1178..1486		294/307 (96%)
		Ion_trans	1224..1464	CDD:278921	229/239 (96%)
		Na_channel_gate	1456..1508	CDD:240441	50/51 (98%)
		IV. /evidence=ECO:0000305	1495..1793		281/297 (95%)
		Ion_trans	1530..1768	CDD:278921	223/237 (94%)
		GPHH	1780..1835	CDD:293510	53/54 (98%)
		IQ	1886..1908	CDD:197470	18/21 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1916..1984		56/69 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83683548
Domainoid	1	1.000	562	1.000	Domainoid score	I5563
eggNOG	1	0.900	-	-		E1_KOG2301
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2237
Inparanoid	1	1.050	3698	1.000	Inparanoid score	I283
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52281
OrthoDB	1	1.010	-	-		D13170at7742
OrthoFinder	1	1.000	-	-		FOG0000268
OrthoInspector	1	1.000	-	-		oto133459
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	LDO	PTHR10037
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X214
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.270