Protein Alignment SCN9A and para

DIOPT Version :10

• Sequence 1: NP_001352465.1
• Gene: SCN9A / 6335
• HGNCID: 10597
• Length: 1988
• Species: Homo sapiens
• Sequence 2: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Alignment Length: 2123
• Identity: 945/2123 - (44%)
• Similarity: 1313/2123 - (61%)
• Gaps: 221/2123 - (10%)

Human    12 FVHFTKQSLALIEQRIAERKSKEPKEEKK----------------------DDDEEAPKPSSDLE 54
            |..||::||..||||||....|:.:.|:|                      :|::|.|:|...||
  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80

Human    55 AGKQLPF-IYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRI 118
            .|..:|. :.|..||.:.|.||||:||||::..||:|::|||.||||:|:.|::||.||:|:||:
  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145

Human   119 SIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGEFTF 183
            :|.||||.|||:.|:.|||.|||.|.|...|. .::.|..|||||||||.||::||||.:..||:
  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209

Human   184 LRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 248
            |||.|||||||||..||:|..::|||::|||||||||||||::::|||||||||:|:|||.|.||
  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274

Human   249 MILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEE-DFR----KYFYYLEG 308
            :|||:|.||||||:|||::||.|..||.:..     .|:.....|..|. |:.    ..:|..:.
  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKF-----PLDGSWGNLTDENWDYHNRNSSNWYSEDE 334

Human   309 SKDALLCGFSTDSGQCPEGYTCVK-IGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLR 372
            .....|||..:.:|||.:.|.|:: .|.||:|||||||:|.||||:.|||||||:||:|||..||
  Fly   335 GISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLR 399

Human   373 AAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEE-QNQANIEEAKQKELEFQQMLDRLKKEQEE 436
            |||..:|:||:|:||||||||:|||||:|||:|:| |.:|..|||.::|         ..:|.||
  Fly   400 AAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE---------AIREAEE 455

Human   437 AEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKG----DA 497
            |.|..||..|..:..::: .....:::|.:.|..:.||   :........:|..|.|||    :.
  Fly   456 AAAAKAAKLEERANAQAQ-AAADAAAAEEAALHPEMAK---SPTYSCISYELFVGGEKGNDDNNK 516

Human   498 EKLS------KSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTS-LF 555
            ||:|      :|||...|:|:.  .....|:....:::||   :.||:.||.|:.||.||:| .:
  Fly   517 EKMSIRSVEVESESVSVIQRQP--APTTAHQATKVRKVST---TSLSLPGSPFNIRRGSRSSHKY 576

Human   556 SFK-GRGR-----------------DIGSETEFADDEHSIFGDNESRRGSLFVP---------HR 593
            :.: ||||                 |......:|||.:::...:| ..|::.||         |.
  Fly   577 TIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSE-ENGAIIVPVYYGNLGSRHS 640

Human   594 PQERRSSNISQASRSPPM--LPVNG--------KMHSAVDCNGVVSLVDGRSALMLPNGQL-LPE 647
            ......|.||..|....:  :.|.|        |:.:....|..|...:|.:..:..|.:| ..:
  Fly   641 SYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRD 705

Human   648 VIIDKATSDDSGT----TNQIHKKRRCSSYLLSED--MLND-----PNLRQRAMSR-ASILTNTV 700
            ..|....:|::|.    .|...:..:..:.:..:|  :|||     .....||..| .|:.....
  Fly   706 YEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPT 770

Human   701 EELEES----RQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFM 761
            |:.:|.    :.|......:....|.:|:|...|:||::.:..||.||||:|.||:|||:||:||
  Fly   771 EDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFM 835

Human   762 AMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLA 826
            ||:||.|.:|.:.||..||..||..||.|..:||:||.|..|||.||||||.:||.|||:||.|.
  Fly   836 AMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLE 900

Human   827 DVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 891
            .|:||||||||||||||||||||||||:||.|:|.::|||||||.||.||:|||||:|||||||:
  Fly   901 GVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKN 965

Human   892 YKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGN 956
            |.:...:..|. .||||:..||.|||:||||||||||||:|||||.| |...|:..::..:||||
  Fly   966 YHDHKDRFPDG-DLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGN 1028

Human   957 LVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLRE-FILKAFSKKPKI 1020
            |||||||||||||:|.|.:|:|...|.|.|.:..|..||.:..::||:.:.: |.|    .:.|:
  Fly  1029 LVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKL----IRNKL 1089

Human  1021 SREIRQAEDLNTKKENYIS---------------NHTLAEMSKGHNFLKEKDKISGFGSSVDKHL 1070
            :.:|  ::..:.::.|.||               .|...|:..||      |:|...| .:.|.:
  Fly  1090 TNQI--SDQPSGERTNQISWIWSEGKGVCRCISAEHGDNELELGH------DEILADG-LIKKGI 1145

Human  1071 MEDS-------DGQSF-IH------NPSLTVTVPIAPGESDLENMNA---------EELSSDSDS 1112
            .|.:       ||..| ||      .|..:..:..|. :.|..::|:         ::.|....:
  Fly  1146 KEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNAT-DDDTASINSYGSHKNRPFKDESHKGSA 1209

Human  1113 EYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSD-------------EPEACFTDGCVWRFS 1164
            |..:....|.:|.|...:|..|..|| |.|..|::.|             .|..|..|....:|.
  Fly  1210 ETMEGEEKRDASKEDLGLDEELDEEG-ECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFP 1273

Human  1165 CCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYA 1229
            ....:.:|...:.|.|:|...::::|:.:||:.::.|||:||.|||.||:::.::..::.||.|.
  Fly  1274 ILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYM 1338

Human  1230 DKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRA 1294
            |:|||.||.||||:||:|.|:|.|||||||||||:||.|||:..||:.:|...:...|::|||||
  Fly  1339 DRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRA 1403

Human  1295 LRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRF 1359
            ||||||:||.:|||||||||:.|||||.|||||||||||||:||||.|||||:::| ...:|::.
  Fly  1404 LRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC-EDMNGTKL 1467

Human  1360 PASQVPNRSECFALMNVSQNVRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQ 1424
            ....:|||:.|     .|:|..|.|..:|||:||..||.|.||||||||..||..|:||..||||
  Fly  1468 SHEIIPNRNAC-----ESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQ 1527

Human  1425 PKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQ-DIFMTEEQKKYYNAMKKL 1488
            |..|.::|||:|||.||||||||||||||||||||||:||||.||. ::||||:||||||||||:
  Fly  1528 PIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKM 1592

Human  1489 GSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVV 1553
            |||||.|.||||..:.|..:|::||::.|||.||:.|.|||.||.:::...|.....||.::|.:
  Fly  1593 GSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAI 1657

Human  1554 FIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIG 1618
            |:::|:.||:||:.:||::||...||:||.||||:||:|:.|:|:||.|||||||.||:|:|::|
  Fly  1658 FVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVG 1722

Human  1619 RILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFET 1683
            |:|||||||||||||||||.|||||||||.|||||||||:||||||.|.:||::.||||::||:|
  Fly  1723 RVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKT 1787

Human  1684 FGNSMICLFQITTSAGWDGLLAPILNSK---PPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYII 1745
            ||.|||.|||::|||||||:|..|:|.:   |||.|  |.:|     |:||:.:|||.:.:||::
  Fly  1788 FGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDND--KGYP-----GNCGSATVGITFLLSYLV 1845

Human  1746 ISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALD 1810
            ||||:|:||||||||||:|.|||:..|.|::||::|:||:|::|||:.||:|.:.:||:|...|:
  Fly  1846 ISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLE 1910

Human  1811 PPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKV 1875
            |||.|.||||.::|:||:|:..||.::|:|||.|.||......|.......::.|  ::|.|...
  Fly  1911 PPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGE--IAARPDTE 1973

Human  1876 SYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNEN 1940
            .|||:::||.|::|:..|.:||.|:|:::.|.............||..|.  :..|.|.|...:.
  Fly  1974 GYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDP--DAGDPAPDEATDG 2036

Human  1941 SSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKGKDS 1983
            .:|...|.:.:.|:..:.|:           |.:.....|:|:
  Fly  2037 DAPAGGDGSVNGTAEGAADA-----------DESNVNSPGEDA 2068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN9A	NP_001352465.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..55		11/50 (22%)
		I. /evidence=ECO:0000305	112..410		173/304 (57%)
		Ion_trans	125..410	CDD:459842	165/291 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..543		23/91 (25%)
		Na_trans_cytopl	535..694	CDD:463401	46/209 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..611		12/54 (22%)
		II. /evidence=ECO:0000305	726..989		164/262 (63%)
		Ion_trans	743..956	CDD:459842	136/212 (64%)
		Na_trans_assoc	982..1187	CDD:461936	54/256 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1102..1148		13/54 (24%)
		III. /evidence=ECO:0000305	1180..1488		186/308 (60%)
		Ion_trans	1191..1466	CDD:459842	166/274 (61%)
		Na_channel_gate	1458..1510	CDD:240441	35/52 (67%)
		IV. /evidence=ECO:0000305	1497..1795		174/300 (58%)
		Ion_trans	1514..1770	CDD:459842	155/258 (60%)
		GPHH	1782..1829	CDD:465306	24/46 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1934..1988		8/50 (16%)
para	NP_001259619.1	Ion_trans	152..436	CDD:459842	164/289 (57%)
		Na_trans_cytopl	555..740	CDD:463401	39/185 (21%)
		Ion_trans	817..1028	CDD:459842	136/212 (64%)
		Na_trans_assoc	1054..1296	CDD:461936	54/256 (21%)
		Ion_trans	1300..1571	CDD:459842	168/276 (61%)
		Na_channel_gate	1561..1613	CDD:240441	35/51 (69%)
		Ion_trans	1621..1871	CDD:459842	155/256 (61%)
		GPHH	1882..1929	CDD:465306	24/46 (52%)