Protein Alignment SCN8A and cch1

DIOPT Version :8

• Sequence 1: NP_001317189.1
• Gene: SCN8A / 6334
• HGNCID: 10596
• Length: 1980
• Species: Homo sapiens
• Sequence 2: NP_593894.1
• Gene: cch1 / 2542812
• PomBaseID: SPAC6F6.01
• Length: 1854
• Species: Schizosaccharomyces pombe
• Alignment Length: 2110
• Identity: 407/2111 (19%)
• Similarity: 728/2111 (34%)
• Gaps: 706/2111 (33%)

Human   105 RFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTF--SNPPDWSKNVEYTFTG 167
            |.:.||...:  ||:.|.|   :|..|.::::.|...|:.:.|.:..  .:|.|.|:.::|....
pombe   163 RANETPGRNL--PFSPILR---QIYNHPLYNIFIFVVIVLHAVLLMIRSDDPHDKSQTIDYLIIV 222

Human   168 I---YTFESLVKIIARGFCIDG------------------FTFLRDPWNWLDFSVIMMAYVTEFV 211
            |   ||.|.|:||...||..||                  .::||..||.:||..|:..::: .:
pombe   223 IGILYTLEMLLKIYLFGFLYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFVAIVALWIS-VI 286

Human   212 DLGNVSALRTFRV---LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
            ........|.|.:   ||..:.:::....:||:.:|.:|...|..|:....|...:.|::|:|.|
pombe   287 GKKQQGIFRLFSMIACLRLTRLLNITRKTETILKSLKESSTPLVQVVSFNAFFGVMIAILGVQFF 351

Human   274 MGNLRNKCVVWPINFNESYLENGT-KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGY 337
            ..:|..:| ||..::.:.||..|. .|..||.            |:....|..|...:...|.|:
pombe   352 KASLNRQC-VWLGDYGDQYLPTGQFCGGHWEN------------GIKRAYLDKNGFPSNVNPRGF 403

Human   338 QCMKAG-----RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFV 397
            .|.:..     .||.....|||.|..:...:|.:|:.:.:.::....:.|......:.|::..:.
pombe   404 ICAEKSVCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISAYF 468

Human   398 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDA 462
            .:.:|::|::|||.
pombe   469 LTLWLMSLVIAVVT--------------------------------------------------- 482

Human   463 IEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRK 527
                                                                             
pombe   483 ----------------------------------------------------------------- 482

Human   528 AFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVE 592
                                                                 :.|.|.:||...
pombe   483 -----------------------------------------------------SSFIDLQHSGKN 494

Human   593 ESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGS 657
            :.|                                      ::||.::
pombe   495 QKE--------------------------------------QKSVDKH----------------- 504

Human   658 HIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPC 722
                                                         ::.|.|.|:
pombe   505 ---------------------------------------------LIRNKLCEK----------- 513

Human   723 WYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAV 787
             |.|.:.|:       ||.       .::..||    |:|               |..::...:.
pombe   514 -YLFYSNFI-------WIS-------FIVAQFV----TLC---------------TQTYDQTSST 544

Human   788 GN--LVFTG----IFTAEMFLKLIAMDPYY--YFQEGWNIFDGFIVSLSLMELSLADVEGLSV-- 842
            .|  |:|..    :..||:.|:..|..|.|  :|:...|:.|..:..|:|:.| |..:....|
pombe   545 ANRYLIFYACVDFLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTL-LPSIRKNPVAF 608

Human   843 --LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECV 905
              |..|.:.|:::.....|....:.|::.::...|.||.|.|.|::||.::..::||
pombe   609 GWLSIFAIARIYRCILLIPYTRKIAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLF-------- 665

Human   906 CKINQDCELPRWHMHD--------FFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCL------- 954
                ||  ||.....|        .:.|||.::::|..| |.:.|:     |.||...
pombe   666 ----QD--LPNDGDSDDDAISFATTYESFLYMYQILTSENWTDVMF-----AIQARLAHLHLSWI 719

Human   955 --IVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHA 1017
              ..|.:..:..|.|||::|:|::..:|     |.::.|.:|..|::.:.|:.:..
pombe   720 PGAFFTLWFLFSNNVVLSMFIAVIQVNF-----APSESDLKMEQLKMYLARLLRNY--------- 770

Human  1018 FMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGN--GTTSGIGSSVEKYIID 1080
                                         |...|.:..|...::||:  |.|           :|
pombe   771 -----------------------------NPFQASLTLNALIKRNGSRKGKT-----------VD 795

Human  1081 EDHMSFINNPNLTVRVPIAVGESDFENLNTED---VSSESDPEGSKDKL-------------DDT 1129
            |.|..::...|      |..|.....|:..::   .|.::.||.||..|             ||.
pombe   796 ESHYEWLYEDN------IIKGFLRVTNIPPKEPLKPSLDTSPELSKYSLAKLSNNFKRFVMRDDP 854

Human  1130 SSS-----------------EGSTIDIKPEVEEVPVEQPE------EYLD------PDACFTEGC 1165
            .|.                 :.:..|::.....|.::|.|      :|.|      |     ...
pombe   855 FSQAYFKRVIGIRWEKDMNLKTAAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKP-----SNR 914

Human  1166 VQRFKCCQVNIEEGLGKSW-------WILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIY-- 1221
            ::||  ||..:..|:.:.:       |:.|.          .:.||...||.   |:..|.|.
pombe   915 IRRF--CQRLVMPGVNERYGGVEPYQWVYRV----------IQVFIYACILT---AVIIECIATP 964

Human  1222 IEQRKTIRTILEYA-----DKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLV 1277
            |.:|..:....::|     :..|..||.:|..:|..|.||.    .:..:.|..:||.::....:
pombe   965 IYERDHLLNDKQHAWFVWTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWI 1029

Human  1278 SLIANALGYSELGAIKSLRTLRALRPLRALSRFE-GMRVVVNALVGAIPSIMNVLLVCLIFWLIF 1341
            :|.|....::.|.  ::.|..:|||.||.::..: ..|:..:||:.....|.:..:|.....:.|
pombe  1030 NLYAVLTSHALLS--RAFRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPF 1092

Human  1342 SIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTEC--EKLMEGNNTEI----RWKN-VKINFDNV 1399
            ::...|:|.|..:.| |:        ::|.:.::|  |.....||.|:    .|.| ...:||..
pombe  1093 ALWAKNVFGGLLYSC-ND--------DNVLSASQCVLEYASTPNNWEVWAPRVWSNPPDYDFDRF 1148

Human  1400 GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVII 1464
            ....|||.::|:.:||:|||.:.:|....:.||:...:....::||:|.:....:.|.|||.:||
pombe  1149 PHALLALFEIASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIII 1213

Human  1465 DNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQK-PIPRPLNKIQGIVFDFVTQ------Q 1522
            .|:.::.     ...|.|.||:.:....:|:.|.:|.| |..|||. ::|:.:||..|      :
pombe  1214 SNYAERT-----GSAFFTAEQRAWLELRRKIKSMRPSKRPAIRPLG-LRGLCYDFAVQKHGIWRR 1272

Human  1523 AF-DIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIG-W 1585
            .| .:.|:.|:.|  :|:..........:.|.::   |:..|.:|....:|::.|..|||... |
pombe  1273 TFTGLYIVHLLFL--LTIFYPCPIAYTYVRNSIF---LILSICYTINICVKVYGLSFYYFFHSFW 1332

Human  1586 NIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1650
            |:|| |||.|..:...:|.:.:....|.||.:...|..:  .:.||........|...::.|||:
pombe  1333 NMFD-VVVTLGSLTCNIAILAKFENRSLTLLQTTLLVLV--TVHLIPKFDNFDQLSKTVVASLPS 1394

Human  1651 LFNIGLLLFLVMFIF------SIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDG 1709
            :|:: :..::|::|.      .|||::....   ..|.:.  ||.:..|:::.||.:|...||:.
pombe  1395 IFSL-IATWIVLYITFAIAFNQIFGLTKLGL---NGGPNK--NFRSIRNALVLLFTMTFGEGWND 1453

Human  1710 LLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFS-VAT 1773
            ::.......|:|....:.    :..||||.......|:::.|||..|.|||:|.::.:||| :.|
pombe  1454 VMHDYTISYPNCVNGDDF----YNSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHT 1514

Human  1774 EESA-DPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADAL-----------EHPLR------ 1820
            :.|: ..|..:||..|.:.|..|||..|.:|.......|..:|           ||.||
pombe  1515 KSSSFTNLQRNDFRQFKDSWAPFDPMVTGYIPKRNAVKFVLSLRGVYDFRIYRDEHTLRSIISKV 1579

Human  1821 --------VP------------------------------KPNTIELIAMDLPMVSGDRIHCLDI 1847
                    ||                              :.|.:..:..::..:.|:.|...:|
pombe  1580 QSKTGQQSVPMLENPLMGSEINLEALDQIIDTIDVNVVKERRNVLNSLCTEIMTLPGNVISFSNI 1644

Human  1848 LFAFTKRVLGDSGELDILRQQMEERFVASNPSK-VSYEP----ITTTLRRKQ------------- 1894
            |.......:.|..|...:...:...:|.|...| :..|.    :.|::.||.
pombe  1645 LMLVVLHKIVDHREAFPISDYIRRAYVLSELEKSIRMEKLLGLVETSIIRKTFLQHMEEKKKALE 1709

Human  1895 ------EEVSAVV----LQRAYRGHLARRGFICKKTTSNKLENGGTHREKKEST-PSTASLPSYD 1948
                  .|||.::    :|...|.|.|....:...|.:..:.:...  ...||| |:.||....|
pombe  1710 NPFILLSEVSEILPETPIQEVLRQHNADPEQLLMSTRTPSVSDRSF--SIVESTVPTIASGEGDD 1772

Human  1949 SVTKPEKEKQQRAEEGRRERAKRQKEVRES 1978
            :.:..:..|.....|.||..:.::..:|.|
pombe  1773 NHSVEDHLKVPTDNEPRRSPSLKEVLLRGS 1802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN8A	NP_001317189.1	I. {ECO:0000305}	114..442		77/360 (21%)
		Ion_trans	131..421	CDD:306908	72/322 (22%)
		Na_trans_cytopl	502..688	CDD:314757	7/186 (4%)
		II. {ECO:0000305}	735..1007		67/302 (22%)
		Ion_trans	752..965	CDD:306908	53/243 (22%)
		Na_trans_assoc	991..1192	CDD:310839	41/255 (16%)
		III. {ECO:0000305}	1180..1495		80/341 (23%)
		Ion_trans	1197..1473	CDD:306908	73/295 (25%)
		Na_channel_gate	1465..1517	CDD:240441	14/53 (26%)
		IV. {ECO:0000305}	1504..1801		84/313 (27%)
		Ion_trans	1522..1776	CDD:306908	67/263 (25%)
		GPHH	1780..1843	CDD:318993	21/118 (18%)
		IQ	1894..1915	CDD:197470	7/44 (16%)
cch1	NP_593894.1	Ion_trans	201..485	CDD:278921	68/467 (15%)
		Ion_trans	533..748	CDD:278921	57/255 (22%)
		Ion_trans	968..1220	CDD:278921	65/263 (25%)
		Ion_trans	1289..1517	CDD:278921	62/244 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.966	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R175
TreeFam	0	0.000	Not matched by this tool.
	3	2.940