Protein Alignment SCN8A and scn2a

DIOPT Version :8

• Sequence 1: NP_001317189.1
• Gene: SCN8A / 6334
• HGNCID: 10596
• Length: 1980
• Species: Homo sapiens
• Sequence 2: XP_017953100.1
• Gene: scn2a / 100486750
• XenbaseID: XB-GENE-6447552
• Length: 1970
• Species: Xenopus tropicalis
• Alignment Length: 2013
• Identity: 1423/2014 (71%)
• Similarity: 1625/2014 (81%)
• Gaps: 92/2014 (5%)

Human     6 LAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYG 70
            :.|||||||:.||.|||..||:||:|.|.....:    .:::.|::.||||.|||||:|||||||
 Frog     6 IVPPGPDSFRYFTRESLKAIEKRISEEKENNAKQ----EQKEGEENGPKPNRDLEAGQSLPFIYG 66

Human    71 DIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFS 135
            |||..:|:.||||.||||..||||:|||:||||||||||.|||||:|||.:|:.|||||:||:|:
 Frog    67 DIPPRMVSEPLEDLDPYYANQKTFIVLNKGKTLFRFSATSALYILTPFNPVRQAAIKILVHSLFN 131

Human   136 MIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFS 200
            |:|||||||||||||.||||:|:||||||||||||.|||:||:|||||::.||||||||||||||
 Frog   132 MLIMCTILTNCVFMTLSNPPEWTKNVEYTFTGIYTLESLIKILARGFCLEKFTFLRDPWNWLDFS 196

Human   201 VIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 265
            ||::|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   197 VIVLAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 261

Human   266 ALIGLQLFMGNLRNKCVVWPIN----------FNESYLENGTKGFDWEEYINNKTNFYTVPGMLE 320
            ||||||||||:|||||::||.|          ||||.                   ||.:....:
 Frog   262 ALIGLQLFMGHLRNKCLLWPYNSSVDISLYEHFNESL-------------------FYKLENQKD 307

Human   321 PLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGK 385
            ||:||||||.|:|||||.|:||||||||||||||||:||||:||||||||.||||||||||||||
 Frog   308 PLVCGNSSDTGKCPEGYVCVKAGRNPNYGYTSFDTFNWAFLSLFRLMTQDCWENLYQLTLRAAGK 372

Human   386 TYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQ--A 448
            |||||||||||:||||||||||||||||||||||||:|||.||||||    ::|||||||||  |
 Frog   373 TYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATIEEAVQKEAEF----QRLKKQQEEAQALA 433

Human   449 AAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPE 513
            ||:|...|. |::..||.|.|  .:...||.:|||||||||||||.||:|||....:|:||||.|
 Frog   434 AAVADVFGE-SQELSEEVGLE--DASECSSTVSKLSSKSAKERRNWRKQRKQVAHCDGQEKGDKE 495

Human   514 KVFKSESEDGMRRKA--FRLPDNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRF 574
            |.:||.|||.::||.  |.....|:.  ||.|:.:||||||.|..|..|.|||:|||||:  .|.
 Frog   496 KCYKSGSEDSIKRKGLNFTREGRRLEEYRKSSMPHQSLLSIQGPVFSPRRNSKTSIFSFK--DRA 558

Human   575 RDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKR 639
            :|.||||:|||||.||.|| :.|||.||:|.|.|.||:     |..||.||||||.|.|..:.|.
 Frog   559 KDVGSENDFADDERSTFEE-DSRRDPLFVPGRHRARRN-----SNISQTSRSSRILPLLSMNGKM 617

Human   640 NSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVV 704
            :|||||||||||:||..:.||  |.||.||....:|:.|.|..:|||.:.....:.|..||.|::
 Frog   618 HSTVDCNGVVSLVGGSSAPIG--LFPEGTTTETDRKRRPSSYKISMDLMEDPSLRQRAQSIASIL 680

Human   705 TNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLF 769
            |||: |||:||:||||.|||||||.||||:|...|:|:|.||.||||||||||||||.|||||:|
 Frog   681 TNTM-EELQESRRKCPSCWYKFANCFLIWDCCEAWLKVKRIVKLIVMDPFVDLAITISIVLNTIF 744

Human   770 MAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSL 834
            ||:||..|||.|..||..||.||||||||||.|||||:|||||||||||||||.|||||||||.|
 Frog   745 MAVEHAHMTPYFISVLTTGNQVFTGIFTAEMVLKLIALDPYYYFQEGWNIFDGLIVSLSLMELGL 809

Human   835 ADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 899
            :...|.||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||
 Frog   810 SSTGGFSVLRSFRLLRVFKLAKSWPTLNKLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK 874

Human   900 SYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIG 964
            |||||||||.::||||||||:||||||||||||||||||||||||||||||:|||:|||:|||||
 Frog   875 SYKECVCKIAENCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLLVFMLVMVIG 939

Human   965 NLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHF--KQRE 1027
            |||||||||||||||||:|||:|||:|.|:||:||:|.||::|||..|:.:..|.:..|  ||::
 Frog   940 NLVVLNLFLALLLSSFSSDNLSATDEDSEINNIQIAVGRIQRGVASGKIILREFFEKLFLQKQKD 1004

Human  1028 ADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDE-DHMSFINNPN 1091
            .:|.|.|:|...|...|:..:...:|.:..:..::.:|.||.|||||||...:| ::|:.||..:
 Frog  1005 INETKQLEETPGKNDTCVLGNAVVEILKEKNDVRDSDGMTSEIGSSVEKSAENEKEYMTVINKTS 1069

Human  1092 LTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIK----PEVEEVPVEQPE 1152
            |||.||||.|||||||.|||:.|||||||.:|:|:..:||||||||||:    ..:||....:.|
 Frog  1070 LTVAVPIAPGESDFENPNTEEFSSESDPEETKEKIKVSSSSEGSTIDIRAPGVERIEEFLDYEYE 1134

Human  1153 EYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAF 1217
            |..||:.|||:.||..|.|||:|||.|.|:.||.|||||:.||||:|||:|||||||||||||||
 Frog  1135 ETFDPEPCFTDDCVASFTCCQINIENGTGRDWWNLRKTCYTIVEHSWFESFIIFMILLSSGALAF 1199

Human  1218 EDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIAN 1282
            ||||:|||:.::.|||||||||.||||:||||||.||||:|:||||||||||:||.:||||||||
 Frog  1200 EDIYVEQRRNVKAILEYADKVFAYIFIMEMLLKWVAYGFIKYFTNAWCWLDFIIVDISLVSLIAN 1264

Human  1283 ALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1347
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
 Frog  1265 ALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVN 1329

Human  1348 LFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNT-EIRWKNVKINFDNVGAGYLALLQVAT 1411
            |||||::||.|.||.:.|...||||.::|.  |..|.| ..||||||:|||||||||||||||||
 Frog  1330 LFAGKFYYCVNTTSGVPFPATDVNNYSDCR--MYINTTGAARWKNVKVNFDNVGAGYLALLQVAT 1392

Human  1412 FKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG 1476
            |||||.|||||||||:.:||||||:|..||:|||.|||||||||||||||||||||||||||..|
 Frog  1393 FKGWMPIMYAAVDSREINEQPKYENNTTMYLYFVAFIIFGSFFTLNLFIGVIIDNFNQQKKKIRG 1457

Human  1477 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMV 1541
            |||||||||||||||||||||||||||||||.|..||::|||||:|||||:||:||.|||||||:
 Frog  1458 QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANCCQGLIFDFVTKQAFDIIIMILIFLNMVTMMI 1522

Human  1542 ETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADII 1606
            |||.||::||..||.||.||:|.||.|.:||:.:||.|||||||||||.||||||||||||||||
 Frog  1523 ETDDQSQEMEMYLYRINAVFIILFTGEFLLKLISLRQYYFTIGWNIFDLVVVILSIVGMFLADII 1587

Human  1607 EKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMS 1671
            |:||.|||||||||||||||||||||.|||||||||||||||||||||||||||||||::|||||
 Frog  1588 ERYFFSPTLFRVIRLARIGRILRLIKAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMS 1652

Human  1672 NFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCSLDKEHPGSGFKGD 1735
            ||||||.::||||||||||||||||||||||||||||.||.||||. .|||..:.|||||.||||
 Frog  1653 NFAYVKKQSGIDDMFNFETFGNSMICLFQITTSAGWDLLLEPILNSGEPDCDPNAEHPGSLFKGD 1717

Human  1736 CGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDAT 1800
            ||||||||||||||||||||||||||||:|||||||||||||:||.|||||.|||:||||||.|:
 Frog  1718 CGNPSVGIFFFVSYIIISFLIVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDPSAS 1782

Human  1801 QFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDIL 1865
            |||||.||:||||||:.||||||||.|:|||||||||||||||||||||||||||||:.||:|.|
 Frog  1783 QFIEYSKLSDFADALDPPLRVPKPNNIQLIAMDLPMVSGDRIHCLDILFAFTKRVLGEGGEMDSL 1847

Human  1866 RQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLENGGT 1930
            ||.|||||:.||||||.||||||||||||||.||||:||.|      |.|..||..:::...|..
 Frog  1848 RQPMEERFMTSNPSKVPYEPITTTLRRKQEEQSAVVIQRCY------RRFRLKKRQASQTYKGNR 1906

Human  1931 HREKKE------------------STPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEV 1975
            :::.:|                  ::.||.|.||||||.|.::||.::..:.::...|.|.:|
 Frog  1907 NKQIEEIERNVNKSQQRYTTEISDTSTSTMSPPSYDSVEKTQQEKYEKDRQKKKISLKTQNDV 1969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN8A	NP_001317189.1	I. {ECO:0000305}	114..442		259/338 (77%)
		Ion_trans	131..421	CDD:306908	235/300 (78%)
		Na_trans_cytopl	502..688	CDD:314757	99/190 (52%)
		II. {ECO:0000305}	735..1007		227/272 (83%)
		Ion_trans	752..965	CDD:306908	185/213 (87%)
		Na_trans_assoc	991..1192	CDD:310839	101/208 (49%)
		III. {ECO:0000305}	1180..1495		259/316 (82%)
		Ion_trans	1197..1473	CDD:306908	228/277 (82%)
		Na_channel_gate	1465..1517	CDD:240441	45/52 (87%)
		IV. {ECO:0000305}	1504..1801		246/298 (83%)
		Ion_trans	1522..1776	CDD:306908	215/255 (84%)
		GPHH	1780..1843	CDD:318993	52/63 (83%)
		IQ	1894..1915	CDD:197470	11/21 (52%)
scn2a	XP_017953100.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D37221at33208
OrthoFinder	1	1.000				FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910