| Sequence 1: | NP_001317189.1 | Gene: | SCN8A / 6334 | HGNCID: | 10596 | Length: | 1980 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_012826714.1 | Gene: | scn3a / 100125099 | XenbaseID: | XB-GENE-5812330 | Length: | 2019 | Species: | Xenopus tropicalis |
| Alignment Length: | 2036 | Identity: | 1507/2036 - (74%) |
|---|---|---|---|
| Similarity: | 1691/2036 - (83%) | Gaps: | 75/2036 - (3%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSL 65
Human 66 PFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILI 130
Human 131 HSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWN 195
Human 196 WLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVF 260
Human 261 CLSVFALIGLQLFMGNLRNKCVVWPIN--------FNES---YLENGTKGFDWEEYINNKTNFYT 314
Human 315 VPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLT 379
Human 380 LRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQE 444
Human 445 EAQAAAMATSAGTVSEDAIEEEGEEG-GGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEE 508
Human 509 KGDPEKVFKSESEDGMRRKAFR--LPDNRI--GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFR 569
Human 570 GPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLR 634
Human 635 RSVKRNSTVDCNGVVSLIGGPG--SHIGGRLLPE------------ATTEVEIKKKGPGSLLVSM 685
Human 686 DQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIV 750
Human 751 MDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQE 815
Human 816 GWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTL 880
Human 881 VLAIIVFIFAVVGMQLFGKSYKECVCKI-NQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDC 944
Human 945 MEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVA 1009
Human 1010 WTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGT--TSGI 1070
Human 1071 GSSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEG 1134
Human 1135 STIDIKP--EVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEH 1197
Human 1198 NWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTN 1262
Human 1263 AWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSI 1327
Human 1328 MNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNV 1392
Human 1393 KINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLN 1457
Human 1458 LFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQ 1522
Human 1523 AFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNI 1587
Human 1588 FDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1652
Human 1653 NIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR 1717
Human 1718 -PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLS 1781
Human 1782 EDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLD 1846
Human 1847 ILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLA 1911
Human 1912 RRG------------------FICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQ 1958
Human 1959 QRAEEGRRERAKRQKEVRESK 1979 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SCN8A | NP_001317189.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..20 | 10/18 (56%) | |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..62 | 17/33 (52%) | |||
| I. /evidence=ECO:0000305 | 114..442 | 277/338 (82%) | |||
| Ion_trans | 131..421 | CDD:395416 | 247/300 (82%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 446..530 | 47/84 (56%) | |||
| Na_trans_cytopl | 504..702 | CDD:403218 | 99/215 (46%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 568..602 | 22/33 (67%) | |||
| II. /evidence=ECO:0000305 | 735..1007 | 238/272 (88%) | |||
| Ion_trans | 752..965 | CDD:395416 | 193/213 (91%) | ||
| Na_trans_assoc | 991..1192 | CDD:399489 | 123/207 (59%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1107..1148 | 28/42 (67%) | |||
| III. /evidence=ECO:0000305 | 1180..1495 | 272/314 (87%) | |||
| Ion_trans | 1197..1473 | CDD:395416 | 237/275 (86%) | ||
| Na_channel_gate | 1465..1517 | CDD:240441 | 47/51 (92%) | ||
| IV. /evidence=ECO:0000305 | 1504..1801 | 251/297 (85%) | |||
| Ion_trans | 1522..1776 | CDD:395416 | 220/254 (87%) | ||
| GPHH | 1788..1835 | CDD:407139 | 34/46 (74%) | ||
| IQ | 1894..1915 | CDD:197470 | 11/38 (29%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1922..1980 | 29/58 (50%) | |||
| scn3a | XP_012826714.1 | Ion_trans | 151..430 | CDD:278921 | 229/278 (82%) |
| Na_trans_cytopl | 512..627 | CDD:288761 | 61/122 (50%) | ||
| Ion_trans | 786..982 | CDD:278921 | 175/195 (90%) | ||
| Na_trans_assoc | 1008..1216 | CDD:284034 | 123/207 (59%) | ||
| Ion_trans | 1239..1496 | CDD:278921 | 220/257 (86%) | ||
| Na_channel_gate | 1488..1540 | CDD:240441 | 47/51 (92%) | ||
| Ion_trans | 1562..1800 | CDD:278921 | 206/237 (87%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| NCBI | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG52281 | |
| OrthoDB | 1 | 1.010 | - | - | D37221at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000268 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X214 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 5 | 4.930 | |||||