back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN2A and na

DIOPT Version :10

Sequence 1:	NP_066287.2	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_001096981.2	Gene:	na / 45338	FlyBaseID:	FBgn0002917	Length:	2233	Species:	Drosophila melanogaster

Alignment Length:	2165	Identity:	434/2165 - (20%)
Similarity:	755/2165 - (34%)	Gaps:	726/2165 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    56 LEAGKSLPFI--YGDIPPEMVSVPLEDLDPYYINK--------------KTFIVLNKGKAISRFS 104
            |:.|:  ||:  ||  |.|.::   |..|..::||              .|.:.||..|...|:
  Fly   328 LKGGE--PFLADYG--PEESLN---ESADIEWVNKLWVRRLMRLCALVSLTSVSLNTPKTFERY- 384

Human   105 ATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFE 169
              |:|.                                  |:|.::        :...|.::|.|
  Fly   385 --PSLQ----------------------------------FITFAS--------DTAVTLLFTAE 405

Human   170 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT-------------EFVDLGNVSALRTFRV 221
            .:.|:..||....:..:|:|.|...|.::::|.:::             :|..|..:.|.|...:
  Fly   406 MIAKMHIRGVLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLIM 470

Human   222 LRALKTISVIPGLKTIVGALI-QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDN 285
            :|.|:........|:.:..:. :|.:::.:|.:..:|.:|::.|:|:| |.|.|:|.|:.   :|
  Fly   471 IRFLRVFLKFSMPKSRINQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQ-FFGELKNHCVM---NN 531

Human   286 SSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAG-QCPE 349
            :.:::                :.|.:...| ...|.|             ..|....|:| ||..
  Fly   532 TEYDL----------------YKRPILTIN-SLAIPD-------------TFCSMDPDSGYQCSP 566

Human   350 GYICVKAGRNPNY--GYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL------RAAGKTYMIFFV 406
            |.:|:|.....:|  |:..|:..:.:..::::..:|:.|..:....:      |||     .:|.
  Fly   567 GMVCMKMDFLSSYVIGFNGFEDIATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAA-----FYFS 626

Human   407 LVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAES 471
            .:||..::.:.|:.:||:...:.|           ...:||||.
  Fly   627 TMIFFLAWLVKNVFIAVITETFNE-----------IRVQFQQMW--------------------- 659

Human   472 RDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKNDRVRKSESEDSIRRKG 536
                ||.|    ....:.||::.|.::
  Fly   660 ----GARG----HIQKTAASQILSGND-------------------------------------- 678

Human   537 FRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTF 601
                 .|.||.                                                    |.
  Fly   679 -----TGWRLV----------------------------------------------------TI 686

Human   602 EDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSA 666
            :||                :|
  Fly   687 DDN----------------KH-------------------------------------------- 691

Human   667 GQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIA---SILTNTMEELEESRQKCPPC 728
            |.|.||              :.|.   :|..|..|...||:.   .|:|.||....:.|.:
  Fly   692 GGLAPE--------------TCHA---ILRSPYFRMLVMSVILANGIVTATMTFKHDGRPR---- 735

Human   729 WYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSV 793
                                         |.|                 .|.|...|
  Fly   736 -----------------------------DVF-----------------YERYYYIE-------- 746

Human   794 GNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSV--------LR 850
              ||||.:...|...||..:        ||..:  :..|:...||.||....|.:        |.
  Fly   747 --LVFTCLLDLETLFKIYCL--------GWRGY--YKHSIHKFELLLAAGTTLHIVPMFYPSGLT 799

Human   851 SFRLLRVFKLAKSWPTL-NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI 914
            .|::|||.:|.|:.|.| ..:.||.|.. ..||:|.:....::.|.:.:.||||        |.:
  Fly   800 YFQVLRVVRLIKASPMLEGFVYKIFGPG-KKLGSLIIFTMCLLIISSSISMQLF--------CFL 855

Human   915 SNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTV---FMMVMVIGNLVVL 975
               |:..::  ..|..:|:.:|::|..| |:|.|.:.|....:|:...|   |::..:...|:||
  Fly   856 ---CDFTKF--ESFPEAFMSMFQILTQEAWVEVMDETMIRTSKTLTPLVAVYFILYHLFVTLIVL 915

Human   976 NLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKG--------------------------- 1013
            :||:|::|     |||...:|..::..|:.   |.|..
  Fly   916 SLFVAVIL-----DNLELDEDIKKLKQLKF---REQSAEIKETLPFRLRIFEKFPDSPQMTILHR 972

Human  1014 --IDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTS 1076
              .||:..|:||...|.||.:.:..|.:  :|:.......|..::......|.:..:   |.|..
  Fly   973 IPNDFMLPKVRESFMKHFVIELETEDSL--VENCKRPMSECWESNVVFRKQKPVRIM---NKTAK 1032

Human  1077 --GIGSSVEK----YVVDESDYMSFINNPSLTVTVPIAVGESDFENLNT-----------EEFSS 1124
              ..|||:.|    :::::|:....:...|..:.|....|....::..|           ::|.|
  Fly  1033 VRAAGSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGS 1097

Human  1125 ES---DMEESKEKLNATSSSEGSTVDIGA-------------------PAEGEQPEV---EPEES 1164
            .|   .:.....||..|........||.|                   .|:.:|.|:   :.||.
  Fly  1098 RSIRRSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREED 1162

Human  1165 LEPEACFTEDCV-------RKFKCCQISIEEG-----KGKLWWNLRKTCYKIVEHN------WFE 1211
            |.....|.:..:       |..|.||..:...     |..|....||..||.: ||      :.:
  Fly  1163 LRENHPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSL-HNFLGLVTYLD 1226

Human  1212 TFIVFMILLSSGALAFE--DIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGF----QVYF 1270
            ..::|...||..::.||  :..:....|    |:.|:..|.....||:.||.:|.|.    :.|.
  Fly  1227 WVMIFATTLSCISMMFETPNYRVMDHPT----LQIAEYGFVIFMSLELALKILADGLFFTPKAYI 1287

Human  1271 TNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIP 1335
            .:....||..|..||...|....|......|.:.|..||.:||||..:....||.||..|.....
  Fly  1288 KDVAAALDVFIYVVSTSFLCWMPLNIPTNSAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFK 1352

Human  1336 SIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALI---------- 1390
            .|:.|..:.::...||:..||.|:.|:...|.:.|         ::...:|..:.
  Fly  1353 EILLVSTLLILLMFIFASYGVQLYGGRLARCNDPT---------ISRREDCVGVFMRRVFVTKMK 1408

Human  1391 -----ESNQTAR-----WKNV-KVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQ---P 1441
                 :.:..|.     |.|. :.||||:|...|:|.:|.:||||:|:       |:|.::   |
  Fly  1409 LTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEVLSFKGWLDV-------RDVLIKAVGP 1466

Human  1442 KYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGS 1506
            .:.      :|..|:|..|....|.||:||:|.|:::.|     ....:|.:|:::.:..|:|..
  Fly  1467 VHA------VYIHIYIFLGCMIGLTLFVGVVIANYSENK-----GTALLTVDQRRWCDLKKRLKI 1520

Human  1507 KKPQKPIPRP-ANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVF 1570
            .:|....||| ..|.:...:|.....:|...|.:::.:|.:.:.: |..:.:..|..|..::.|.
  Fly  1521 AQPLHLPPRPDGRKIRAFTYDITQHIIFKRVIAVVVLINSMLLSI-TWIKGEVHTERLVIVSAVL 1584

Human  1571 IVLFTGECVLKLISL--RYYYFTIGW----NIFDFVVVILSIVGMFLAELIE---KYFVSPTLFR 1626
            ..:|..|.|:|.|:.  |.|     |    |.:|.:|.:..::.:.|..::.   .||..   |.
  Fly  1585 TFVFVVEVVMKNIAFTPRGY-----WQSRRNRYDLLVTVAGVIWIILQTILRNDLSYFFG---FM 1641

Human  1627 VIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGI 1691
            |:.|    |...:......::.|:..:.:|:...|.|...:||::|.||:.|...|..||...||
  Fly  1642 VVIL----RFFTITGKHTTLKMLMLTVGVSVCKSFFIIFGMFLLVFFYALAGTILFGTVKYGEGI 1702

Human  1692 DDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFF 1756
            ....||.:....:..||:|.|...|:.::...:.. ||.|....::    .:.||||.:..:.:|
  Fly  1703 GRRANFGSPVTGVAMLFRIVTGEDWNKIMHDCMVQ-PPYCTLGNNY----WETDCGNFTASLIYF 1762

Human  1757 VSYIIISFLVVVNMYIAVILENFSV--ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLS 1819
            .::.:|...:|:|:.:|:|:||||:  :.||.| .||..|...|...|...|......|
  Fly  1763 CTFYVIITYIVLNLLVAIIMENFSLFYSNEEDA-LLSYADIRNFQNTWNIVDIHQRGVI------ 1820

Human  1820 DFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD-----ILFAFTKRVLGESGEMDALRIQM 1879
                            .|:.:...|.::.| |:.| |     :||.:.      ..|:|.|.
  Fly  1821 ----------------PVRRVKFILRLLKG-RLEC-DPQKDRLLFKYM------CYELDKLH--- 1858

Human  1880 EERFMASNPSKVSYEPITTTLK------RKQEEVSAIIIQRAYRRYLLKQKVKKVS------SIY 1932
                   |...|::..:...|.      ||..::..::.:..: .||::::|.|::      ...
  Fly  1859 -------NGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEF-EYLVEEEVAKMTIRTWLEGCL 1915

Human  1933 KKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTP-----------------STTS-------PP 1973
            ||.:.:....   ::::||..|  .:|.|:..|.|                 ||.|       ||
  Fly  1916 KKIRAQNASK---QQNSLIAGL--RATNEQPVMRPNIQEDKAPLGAVDKSAISTISGAVAGACPP 1975

Human  1974 SYD--SVTKPEKEKFEKDKS 1991
            :.|  |.|....|..|||.|
  Fly  1976 TSDAFSPTFSSTENEEKDGS 1995

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.