Protein Alignment SCN2A and para

DIOPT Version :8

• Sequence 1: NP_001035232.1
• Gene: SCN2A / 6326
• HGNCID: 10588
• Length: 2005
• Species: Homo sapiens
• Sequence 2: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Alignment Length: 2160
• Identity: 973/2161 (45%)
• Similarity: 1319/2161 (61%)
• Gaps: 282/2161 (13%)

Human    14 FRFFTRESLAAIEQRIAEEKAKRPKQERK---------------------DEDDENGPKPNSDLE 57
            ||.||||||..||||||.|..|:.:.|||                     |||::.||:|:..||
  Fly    16 FRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLE 80

Human    58 AGKSLPF-IYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKL 121
            .|..:|. :.|..|||:.|.||||:||||.|..||:|::|||.|.||||:.|:::|.||||||::
  Fly    81 QGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRV 145

Human   122 AIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTF 186
            ||.||||.||::.|:.|||.||:.|.|...|. .::.|..|||||||||.:|::||||.|..||:
  Fly   146 AIYILVHPLFSLFIITTILVNCILMIMPTTPT-VESTEVIFTGIYTFESAVKVMARGFILCPFTY 209

Human   187 LRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDV 251
            |||.||||||.||..||||..:||||::|||||||||||||::::|||||||||:|:|||.|.||
  Fly   210 LRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDV 274

Human   252 MILTVFCLSVFALIGLQLFMGNLRNKCL-QWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFN 315
            :|||:|.||||||:|||::||.|..||: ::|.|.|         :.|..|.|....||..|  |
  Fly   275 IILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGS---------WGNLTDENWDYHNRNSS--N 328

Human   316 WDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKA-GRNPNYGYTSFDTFSWAFLSLFR 379
            |  |.||:...:        .||||.|.||||.:.|:|::. |.||||||||||:|.|||||.||
  Fly   329 W--YSEDEGISF--------PLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383

Human   380 LMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEE-QNQATLEEAEQKE 443
            ||||||||:||||.|||||..:|:||:::||||||||:|||||:|||:|:| |.:|..|||.::|
  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448

Human   444 AEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKK 508
            |         .::.||| |||.||..|.|          .:..:..|:..::..|..|.....|.
  Fly   449 A---------IREAEEA-AAAKAAKLEER----------ANAQAQAAADAAAAEEAALHPEMAKS 493

Human   509 K-------QKEQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSP---HQSL---- 559
            .       :....||:..:|..::..|..|:       .:|...::..:|..:|   ||:.
  Fly   494 PTYSCISYELFVGGEKGNDDNNKEKMSIRSV-------EVESESVSVIQRQPAPTTAHQATKVRK 551

Human   560 -----LSIRGSLFSPRRNSRAS----LFSFRGRAKDIGSEN---------------DFADDEHST 600
                 ||:.||.|:.||.||:|    :.:.|||....||:.               .:|||.::.
  Fly   552 VSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAV 616

Human   601 ---FEDNDSRRDSLFVPHRHGE--RRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGP 660
               .|:|    .::.||..:|.  .|||  |..|..||:        ...|..|..|.:::: |.
  Fly   617 TPMSEEN----GAIIVPVYYGNLGSRHS--SYTSHQSRI--------SYTSHGDLLGGMAVM-GV 666

Human   661 STLTSAGQLLPE------------GTTTETEIRKRRSSSYHVSMDLLE-------------DPTS 700
            ||:|...:|...            |||......|.....|.:.::..:             :|..
  Fly   667 STMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQ 731

Human   701 RQRA--MSIASILTNTMEE-------------------LEESRQKCPPCWYKFANMCL------- 737
            .|..  |....:|.:.:|:                   .|:..:..|....|...:.|
  Fly   732 TQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFC 796

Human   738 IWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIF 802
            :||||..|||.:..|:|:|.||||:|.||:|||:||:||||:|:.|.::...||..||..||..|
  Fly   797 VWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATF 861

Human   803 TAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTL 867
            ..|..:|::||.|.|||||||||||..||:|||:||||..|:|||||||||||||||||||||||
  Fly   862 AIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTL 926

Human   868 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSF 932
            |:||.|:|.::|||||||.||.||:|||||:|||||||:|.:...:.. |.:||||:..||.|||
  Fly   927 NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFP-DGDLPRWNFTDFMHSF 990

Human   933 LIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDD 997
            :||||||||||||:|||||.| |...|:..|:..:|||||||||||||||||:|.|.:|:|...|
  Fly   991 MIVFRVLCGEWIESMWDCMYV-GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTAD 1054

Human   998 NEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEI--KPLEDLNNKKD---------- 1050
            |:.|.:..|..|:.:...:|||.|.:..:   :.:.|..::|  :|..:..|:..
  Fly  1055 NDTNKIAEAFNRIGRFKSWVKRNIADCFK---LIRNKLTNQISDQPSGERTNQISWIWSEGKGVC 1116

Human  1051 SCIS---NHTTIEIGKDLNYLKDG---NGTTS------GIGSSVEKYVV------DESDYMSFIN 1097
            .|||   ....:|:|.| ..|.||   .|...      .||..:| :.:      ::.....::|
  Fly  1117 RCISAEHGDNELELGHD-EILADGLIKKGIKEQTQLEVAIGDGME-FTIHGDMKNNKPKKSKYLN 1179

Human  1098 NPSLTVTVPI-AVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVE- 1160
            |.:...|..| :.|.........|.....::..|.:||.:|:....|...::....|.|:..::
  Fly  1180 NATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDG 1244

Human  1161 -------PEESLE--PEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVF 1216
                   .|:.|:  |..|..:...:||.......:....:.|.|||...::::|:.:|||.::.
  Fly  1245 DIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVIT 1309

Human  1217 MILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLI 1281
            |||:||.|||.||:::.||..::.:|.|.|::||.||.||||:||:|.||:||||||||||||:|
  Fly  1310 MILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVI 1374

Human  1282 VDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346
            |.|||::..|:.:|...:.|.|::|||||||||||:||.:|||||||||:.|||||.||||||||
  Fly  1375 VMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLI 1439

Human  1347 FWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLG 1411
            |||||:||||.|||||::.|.: ..|......::.|.:.|::   .|.|  |.|..:|||:||..
  Fly  1440 FWLIFAIMGVQLFAGKYFKCED-MNGTKLSHEIIPNRNACES---ENYT--WVNSAMNFDHVGNA 1498

Human  1412 YLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1476
            ||.|.||||||||:.||..|:|||.|:.||..|.|:|||||||.|||||||||||||||||||||
  Fly  1499 YLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNF 1563

Human  1477 NQQKKKFGGQ-DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMIL 1540
            |:||||.||. ::||||:||||||||||:|||||.|.||||..:.|.:||:.||.:.|||.||:.
  Fly  1564 NEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLF 1628

Human  1541 ICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILS 1605
            |.|||.||.::..|.|.....:|.::|.:|:|:|:.||:||:.:|||:||...||:||.||||||
  Fly  1629 IGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILS 1693

Human  1606 IVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLV 1670
            |:|:.|:::||||||||||.||:|:|::||:|||:|||||||||||||.|||||||||.||||||
  Fly  1694 ILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLV 1758

Human  1671 MFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDP-- 1733
            |||:||||||.|.:||.:.||:|::||:|||.|||.|||::|||||||:|..|:|.  ..|||
  Fly  1759 MFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINE--EACDPPD 1821

Human  1734 -DKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEM 1797
             ||.:|     |:||:.:|||.|.:||::||||:|:||||||||||:|.|||:..|.|::||::|
  Fly  1822 NDKGYP-----GNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDM 1881

Human  1798 FYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFT 1862
            :||:|::|||:.||:|.:.:||:|.|.|:|||.|.||||.::|:||:|:..||.::|:|||.|.|
  Fly  1882 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALT 1946

Human  1863 K-------RVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYL 1920
            |       ..:.|:||:..:         |:.|....|||:::||.|::||..|.:||.|:|
  Fly  1947 KDFFARKGNPIEETGEIGEI---------AARPDTEGYEPVSSTLWRQREEYCARLIQHAWR--- 1999

Human  1921 LKQKVK-KVSSIYKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTKPEKE 1984
             |.|.: :....::.|......|.|...|...|:..:...|...|.:.:.|:..:.|:
  Fly  2000 -KHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADA------- 2056

Human  1985 KFEKDKSEKEDKGKD 1999
                |:|.....|:|
  Fly  2057 ----DESNVNSPGED 2067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN2A	NP_001035232.1	I. {ECO:0000305}	111..456		197/348 (57%)
		Ion_trans	150..435	CDD:278921	169/288 (59%)
		Na_trans_cytopl	514..630	CDD:288761	38/152 (25%)
		II. {ECO:0000305}	741..1013		168/272 (62%)
		Ion_trans	776..971	CDD:278921	124/195 (64%)
		Na_trans_assoc	997..1203	CDD:284034	49/247 (20%)
		III. {ECO:0000305}	1190..1504		190/315 (60%)
		Ion_trans	1225..1482	CDD:278921	159/257 (62%)
		Na_channel_gate	1474..1526	CDD:240441	37/53 (70%)
		IV. {ECO:0000305}	1513..1811		178/301 (59%)
		Ion_trans	1548..1786	CDD:278921	147/241 (61%)
		GPHH	1798..1853	CDD:293510	28/55 (51%)
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	171/293 (58%)
		Na_trans_cytopl	515..648	CDD:288761	36/146 (25%)
		Ion_trans	835..1028	CDD:278921	124/195 (64%)
		Na_trans_assoc	1054..1296	CDD:284034	49/247 (20%)
		Ion_trans	1318..1571	CDD:278921	160/259 (62%)
		Na_channel_gate	1561..1613	CDD:240441	36/52 (69%)
		Ion_trans	1636..1871	CDD:278921	147/242 (61%)
		GPHH	1880..1930	CDD:293510	27/50 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG2301
Hieranoid	1	1.000
Homologene	1	1.000				H75001
Inparanoid	1	1.050	1627	1.000	Inparanoid score	I80
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D37221at33208
OrthoFinder	1	1.000				FOG0000322
OrthoInspector	1	1.000				T608898
orthoMCL	1	0.900				OOG5_126819
Panther	1	1.100			O	PTHR10037
Phylome	1	0.910		0.952	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R9280
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900