back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN2A and cac

DIOPT Version :10

Sequence 1:	NP_066287.2	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster

Alignment Length:	1842	Identity:	463/1842 - (25%)
Similarity:	785/1842 - (42%)	Gaps:	479/1842 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTM-SNPPDWTKNV--------EYTFT 163
            :|:|||..|||||....|:....|...::.||:.|||.:.: .:.|...|.|        |..|.
  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81

Human   164 GIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLG---NVSALRTFRVLRAL 225
            .|:..|:.:||||.|..|...::||:.||.:||.|:...::|::..:|   ::..||..||||.|
  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146

Human   226 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEI 290
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|......|...:
  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK- 210

Human   291 NITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVK 355
                      :|...|...|.:|               ||....:.:|.|::.        :|::
  Fly   211 ----------EGESETPCNTDNI---------------LEKATGSFVCNNTTS--------MCLE 242

Human   356 AGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLINL 419
            ....||.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||
  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307

Human   420 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFS 484
            :|.|::                  .||.:..|:::.:||
  Fly   308 VLGVLS------------------GEFAKEREKVENRQE-------------------------- 328

Human   485 ESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE---KNDRVRKSESEDSIRRKGFRFSLEGSRL 546
                           .||.||:::.::|.:|..|   |.:.|..:|                .|.
  Fly   329 ---------------FLKLRRQQQLERELNGYVEWICKAEEVILAE----------------ERT 362

Human   547 TYEKRFSSPHQSLLSIRGSLFSPRRNS--RASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRD 609
            |.|::     ..::..|      |||:  |..|.|. |::|...:|.:.|::::
  Fly   363 TEEEK-----MHIMEAR------RRNAAKRKKLKSL-GKSKSTDTEEEEAEEDY----------- 404

Human   610 SLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGT 674
                                                            |....|.:..:  |:|:
  Fly   405 ------------------------------------------------GDDGYLKTRSK--PQGS 419

Human   675 TTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIW 739
            .|.....::|                                             ::|
  Fly   420 CTGFWRAEKR---------------------------------------------FRF------- 432

Human   740 DCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804
                 |  ::|.|.......||    .:.:.|||:.:|:|||......:..|.....:|.|:|.:
  Fly   433 -----W--IRHTVKTQWFYWFV----IVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMS 486

Human   805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVE----GLSVLRSFRLLRVFKLAKSWP 865
            |||:|:.|:.|..||:..:|.||..::|.|:.|:..:.|:    ||||||:.||||:||:.|.|.
  Fly   487 EMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWS 551

Human   866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFH 930
            :|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:           .||.......|:
  Fly   552 SLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-----------NLPGGTPETNFN 605

Human   931 SF----LIVFRVLCGE-WIETMWDCMEVAG---QTMCLTVFMMVMVI-GNLVVLNLFLALLLSSF 986
            :|    |.||::|.|| |.|.|:..:...|   :.|..:::.:|:|: ||..:||:|||:.:
  Fly   606 TFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAV--- 667

Human   987 SSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDS 1051
              ||||...:                             ..|...:|...|:.|.|::|..:.::
  Fly   668 --DNLANAQE-----------------------------LTAAEEEQVEEDKEKQLQELEKEMEA 701

Human  1052 CISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFEN 1116
            ..::...:|.|       ||                                    ||..|..:.
  Fly   702 LQADGVHVENG-------DG------------------------------------AVAPSKSKG 723

Human  1117 LNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEES---LEPEACFTEDCVRK 1178
            ...|        ||.||:...|              ||.:|.: |..|   |.|..
  Fly   724 KKKE--------EEKKEEEEVT--------------EGPKPML-PYSSMFILSPTN--------- 756

Human  1179 FKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLE 1243
                             .:|:..:.:|...:|:.||:.:|.:||.|||.||...|..:..| :|.
  Fly   757 -----------------PIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILN 803

Human  1244 YADKVFTYIFILEMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYS---ELGA 1301
            |.|..||.:|.:|||||.|..|..:    |....|..:|.::|..:.||...:..|.|   .|..
  Fly   804 YFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLST 868

Human  1302 IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC 1366
            |||||.||.||||:.:.|...::.|.:.::.::.:::|:|:|.::|..|||::||.||.|||::|
  Fly   869 IKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC 933

Human  1367 INYTTGEMFDVSVVNNYSECKA---------LIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422
                |.|....|     :||:.         |:...:...||....::|||....|:|..|.|.:
  Fly   934 ----TDESKHTS-----AECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGE 989

Human  1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG-- 1485
            ||..::..::.:...:..|.....:.|.::::::.|...||.:|:|:.:||..|.:|     |
  Fly   990 GWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQ-----GEA 1049

Human  1486 --QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTM 1548
              ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:..|....|:..||:||..|.:.:
  Fly  1050 ELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLL 1112

Human  1549 MVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGMFLA 1612
            |::..:|.......|.:||:.|..:|:.|.|||:|.... .:|...|||||.:.|:.|||.....
  Fly  1113 MMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWM 1177

Human  1613 ELIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676
            |     |.|.:: ...:||.|..|:::|::....||.||:..:.|..||..:.||:.::.|||||
  Fly  1178 E-----FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAI 1237

Human  1677 FGMSNFAYVKR---EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHP 1738
            .||..|..:|.   |..|....||::|...::.||:..|...|..::...|.....|.|.:| .|
  Fly  1238 IGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEK-AP 1301

Human  1739 GSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1803
            |..    ||: ::...:|||:|.....:::|:::|||::||...|.:|: .|.....:.|..:|.
  Fly  1302 GEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWA 1360

Human  1804 KFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTK 1863
            ::||:||..|.:.::.|....:||||....  ||::   :||.|::|:....|:.....|||..:
  Fly  1361 EYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIR 1425

Human  1864 RVLG----ESGEMDALRIQMEE 1881
            ..|.    ...|||...:::.|
  Fly  1426 ENLSIKMRAPEEMDQADMELRE 1447

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.