back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCN2A and cca-1

DIOPT Version :9

Sequence 1:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens
Sequence 2:	NP_001367691.1	Gene:	cca-1 / 181045	WormBaseID:	WBGene00000367	Length:	1885	Species:	Caenorhabditis elegans

Alignment Length:	1950	Identity:	490/1950 - (25%)
Similarity:	832/1950 - (42%)	Gaps:	486/1950 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   105 ATPALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP----PDW----------T 155
            |.|||.......|.||.|:::::...|:.:.|..|:.|||.:.|..|    ||.          .
Worm   106 AEPALRCFYQARPPRKWALQMVMSPWFDRITMAVIMINCVTLGMYRPCEDGPDCDTYRCQILDII 170

Human   156 KNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFV---DLG---NVS 214
            .|..:.:   :.||.:|||:|.|| .....::.|.||.|||.:: .|.:.|||   .||   |::
Worm   171 DNCIFVY---FAFEMVIKIMALGF-YGPAAYMSDTWNRLDFFIV-MAGIAEFVLHEYLGGNINLT 230

Human   215 ALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCL 279
            |:||.||||.|:.::.||.::.:|..|:.::..|.:|::|..|...:|.::|:||:.|.|||:|:
Worm   231 AIRTVRVLRPLRAVNRIPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCV 295

Human   280 QWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDA---LLCGN- 340
            ...|  .:...|.::.|||            |.:..:  ||.:.:...::..|.||   ..|.|
Worm   296 INLP--KTISENQSALFNN------------VKLTRF--YIPEDTSLEYICSQPDANGLHTCSNL 344

Human   341 ---SSDAGQCP---EGY----------------ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQ 383
               :.|..:|.   :.|                .|....|||..|..|||...:|::::|.:::.
Worm   345 PPYTVDGVKCNLTLDEYDKVTNDSCINWNIYYNECQVMQRNPFQGSVSFDNIGFAWVAIFLVISL 409

Human   384 DFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQ 448
            :.|.::......|......|:|||:|.:|:|::|||.|.|:|..:          ||.|..|.::
Worm   410 EGWTDIMYYVQDAHSFWNWIYFVLLIVIGAFFMINLCLVVIATQF----------AETKRRETER 464

Human   449 MLEQLKKQQEE------AQAAAAAASAESRDFSGAGGI----GVFSESSSVASK-----LSSKSE 498
            ||::.|.....      ......|:|.|..|...|..:    ..|..:...|.|     :..::|
Worm   465 MLQERKMLLNRDSISCTGSEIGGASSKEEGDTVYAAFVRFIGHTFRRTKRAAKKKYTAYMEERAE 529

Human   499 KELKNRRKKKKQK-----------EQSGEEEKNDRVRKSESEDSIRRKGFRFSLEGSRLTYEKRF 552
            ::...|::::|.|           |::.:||....:.:...:|.|.:.|     :|.|:   ||.
Worm   530 RKSSERQQRRKSKLDDMATLSRIEEKAEDEEDETTITRENGDDQIEQNG-----DGVRI---KRV 586

Human   553 SSPHQSLLSI-RGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHR 616
            ....:..:.| .|:...|.....:|                   ||.|   |.|...|.::
Worm   587 KIEEEPKIKIGNGNSNGPHYKHSSS-------------------DEES---DEDGEEDQVY---- 625

Human   617 HGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIR 681
                                                                   :|
Worm   626 -------------------------------------------------------DG-------- 627

Human   682 KRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWL 746
                                                 ||:::|..|        ..:|     |.
Worm   628 -------------------------------------EEAKKKSTP--------SKLW-----WF 642

Human   747 KVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKII 811
            :.| :...|:.|.|. ..|.:.|::|||.|.:|::...|..:.:|...||.||.:|..||.||||
Worm   643 REK-IQKFVICDHFT-RGILVAILVNTLSMGVEYHQQPEILTVILEYSNLFFTALFALEMLLKII 705

Human   812 AMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGN 876
            |...:.|..:|:|:|||.||:||::||......||||||:|||||:.||.:..|.|...:.::
Worm   706 ASGLFGYLADGFNLFDGGIVALSVLELFQEGKGGLSVLRTFRLLRILKLVRFMPALRYQLVVM-- 768

Human   877 SVGALGNLTL---VLAIIVFIFAVVGMQLFGKSY------------KECV--------------- 911
             :..:.|:|:   :|.:.:|||:::||.|||..:            |:|.
Worm   769 -LRTMDNVTVFFGLLVLFIFIFSILGMNLFGCKFCKVEEKFLGGLAKKCERKNFDTLLWALITVT 832

Human   912 -------CK----------------ISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCME 952
                   ||                ||:.||..|.:..:|..:.:.||::|..| |...:::.|.
Worm   833 LGMVLFGCKFCNHPDTGLQCTSAQVISSICECDRMNFDNFLFATVTVFQILTQEDWNMVLFNGMA 897

Human   953 VAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSD-------------NLAATDDDNEMNNLQ 1004
            .......| .|:.:|..||.|:.||.:|:|:..|...             ..|..::|.....|:
Worm   898 QTNPWAAL-YFVALMTFGNYVLFNLLVAILVEGFQESKEEEKRQLEEDARKQAVEEEDERKRELE 961

Human  1005 IAVGR-----MQKGI---------------------------DFVKRK----IREFIQKAFVRKQ 1033
            :.:.:     ...|:                           ...:||    :...|.|..|.:.
Worm   962 LIIAKTTSPAFNNGVAPAECTCQRPSSPEESPSPRLLSANYHPSPERKHSANLDAIIDKRLVLRN 1026

Human  1034 KALDEIKPLEDLNNKKDSCISNHTT--IEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFI 1096
            .|..:..|:.:  .:.||.::.|.:  :.:...:.|.:....:.||:....
Worm  1027 SAPFDRSPVSE--GRDDSRLNRHASLVLPVANGVPYRRQRVHSWSGLCHHF-------------- 1075

Human  1097 NNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEP 1161
             ||:..|....|:         .|.::.|..:|.|:|...|.:.              |:...|.
Worm  1076 -NPNCPVHGRRAL---------IETYAREKFLEASQELKQALAE--------------EEKRNEA 1116

Human  1162 EESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALA 1226
            :::........:.|:.......:.:...|..    ||..|.:..:..||:..::|.|.::...||
Worm  1117 KQNTFVRKLLKKTCLHNRTEFSLFLMGPKNP----LRIKCLQTTQKKWFDYTVLFFIGINCITLA 1177

Human  1227 FEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLV 1287
            .|...|......:..|..:..:||.||..||::|.:|.|..:    ||.:.|..||.::|.:||:
Worm  1178 MERPSIPPDSFERQFLHISGYIFTVIFTGEMMMKVIANGCFIGQAAYFKDGWNILDGILVVISLI 1242

Human  1288 SLTANALGYSE----LGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFW 1348
            ::....|...:    .|.|:.||.||||||||.::|..|:::||..|:.::..|.|::|:|..|:
Worm  1243 NIAFELLATGDSPKIFGVIRVLRLLRALRPLRVINRAPGVKLVVMTLISSLKPIGNIVLICCTFF 1307

Human  1349 LIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYL 1413
            :||.|:||.||.|..||||....|.      |...::|   ||..:. :|.|.:.||||:|...:
Worm  1308 IIFGILGVQLFKGMMYHCIGPEVGN------VTTKADC---IEDYRN-KWVNHRYNFDNLGQALM 1362

Human  1414 SLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQ 1478
            ||..:::..||:.|||..:|:..|::||....|.:..:||:.|::...||.||:|:||:::||::
Worm  1363 SLFVLSSKDGWVSIMYQGIDAVGVDVQPIENYNEWRMIYFISFLLLVGFFVLNMFVGVVVENFHK 1427

Human  1479 QKKKFGGQDIFMTEEQKKYYNAMKKLGSK-KPQKPIPRPANKFQGM----------------VFD 1526
            .|:....:   |.|::|:     |:|..| |.||.....|.|.:.|                :..
Worm  1428 CKEALEKE---MREKEKE-----KRLKRKLKRQKFEESMAGKRKKMERNYPYYHDYGHTRLFLHG 1484

Human  1527 FVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFT 1591
            .||.:.||::|..:|.:|:::|.:|.......:..:|..:|..|..:||.|..:|||:|.:..|.
Worm  1485 IVTSKYFDLAIAAVIGINVISMAMEFYMMPMGLKYVLKALNYFFTAVFTLEAAMKLIALGFKRFF 1549

Human  1592 I-GWNIFDFVVVILSIVGMFLAEL-IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALM 1654
            | .||..|..:|||||.|:...|. ..:..::||:.||:|:.||.|:|:|:|.|||||:||..:.
Worm  1550 IEKWNRLDMFIVILSIAGIIFEEFEALELPINPTIIRVMRVLRIARVLKLLKMAKGIRSLLDTVG 1614

Human  1655 MSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV-------GIDDMFNFETFGNSMICLFQITT 1712
            .:||.:.|:|.|.||:.||:|..|:..|.  |.|.       |:.:..:|:.||.:.:.||:|.|
Worm  1615 EALPQVGNLGSLFFLLFFIFAALGVELFG--KLECSEDHPCDGLGEHAHFKNFGMAFLTLFRIAT 1677

Human  1713 SAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILE 1777
            ...|:|::...|..   ||| ..||..::.   |.:|.:...|||.:::||..|:||:.:||:::
Worm  1678 GDNWNGIMKDALRD---DCD-SSDHCETNC---CVDPILAPCFFVIFVLISQFVLVNVVVAVLMK 1735

Human  1778 NFSVA----TEESAEPL----------SEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPP 1828
            :...:    .|..|||.          |:||     |:.|:.:|.|.:.::..:|.:..:..:.|
Worm  1736 HLEESNKRDAEGPAEPTGENIENEITKSDDD-----EIVEEHEPLAIEHVKEGELDEEEETEEGP 1795

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.