Protein Alignment SCN2A and scn1a

DIOPT Version :8

• Sequence 1: NP_001035232.1
• Gene: SCN2A / 6326
• HGNCID: 10588
• Length: 2005
• Species: Homo sapiens
• Sequence 2: XP_012826731.1
• Gene: scn1a / 100488621
• XenbaseID: XB-GENE-978019
• Length: 2020
• Species: Xenopus tropicalis
• Alignment Length: 2024
• Identity: 1703/2025 (84%)
• Similarity: 1849/2025 (91%)
• Gaps: 23/2025 (1%)

Human     1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQERKDEDDENGPKPNSDLEAGKSLPFI 65
            |||:.||||||||||:|:||||.|||:||||||||:||||.:|:||:|||||:||||||||||||
 Frog     1 MAQARLVPPGPDSFRYFSRESLEAIEKRIAEEKAKKPKQEHRDDDDDNGPKPSSDLEAGKSLPFI 65

Human    66 YGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSL 130
            ||||||.|||.|||||||||:|:|||||||:||||.|||||.||||||||||:||:|||:|||||
 Frog    66 YGDIPPGMVSEPLEDLDPYYMNQKTFIVLNRGKAIFRFSATSALYILTPFNPLRKVAIKVLVHSL 130

Human   131 FNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLD 195
            |:||||||||||||||||||||:|||||||||||||||||||||||||||||.||||||||||||
 Frog   131 FSMLIMCTILTNCVFMTMSNPPEWTKNVEYTFTGIYTFESLIKILARGFCLEKFTFLRDPWNWLD 195

Human   196 FTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLS 260
            |:||..|||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   196 FSVIVMAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLS 260

Human   261 VFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSH 325
            ||||||||||||:||||||||||.:.....||....|.:::.:....|.|.|.|:|:|||.||:|
 Frog   261 VFALIGLQLFMGHLRNKCLQWPPIDYFPLTNIPPILNGTMNIHDPFGNTTNSTFDWEEYITDKNH 325

Human   326 FYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLY 390
            ||.||||.|.||||||||:||||:||||||.|:||||||||||||||||||||||||||:|||||
 Frog   326 FYKLEGQKDFLLCGNSSDSGQCPKGYICVKTGKNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLY 390

Human   391 QLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 455
            ||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
 Frog   391 QLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK 455

Human   456 QQEEAQAAAAAASAESRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKN 520
            |||||||||.||...||::|..||.|..|||||.||||||||.|:.:||:||:||||...|.||.
 Frog   456 QQEEAQAAAVAALNMSREYSEDGGFGPLSESSSEASKLSSKSAKDRRNRKKKRKQKELGEEYEKG 520

Human   521 D--RVRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRGR 583
            |  :..|||||.||:|||||||:||:|||||.:||||||||||||||||||||||||||||||.|
 Frog   521 DDEKFPKSESETSIKRKGFRFSIEGNRLTYENKFSSPHQSLLSIRGSLFSPRRNSRASLFSFRNR 585

Human   584 AKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAV 648
            |||:|||||||||||||||||:|||.|||||:||||||:||:||.|::|:.:.:||.||||||.|
 Frog   586 AKDVGSENDFADDEHSTFEDNESRRGSLFVPNRHGERRNSNISQVSKSSKTMTVLPANGKMHSTV 650

Human   649 DCNGVVSLVGGPSTLTS-AGQLLPE-----------GTTTETEIRKRRSSSYHVSMDLLEDPTSR 701
            ||||||||:||||..|| .|.||||           |||||||||||:||.|.|.||||||||:|
 Frog   651 DCNGVVSLLGGPSVPTSPVGLLLPEVIVDKPASDDNGTTTETEIRKRKSSCYQVPMDLLEDPTAR 715

Human   702 QRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAIT 766
            |||:|:|||||||:|||||||||||||||||||..||||||:.||.|||:|.|:|||||||||||
 Frog   716 QRALSVASILTNTVEELEESRQKCPPCWYKFANTFLIWDCCENWLTVKHIVKLIVMDPFVDLAIT 780

Human   767 ICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIV 831
            ||||||||||||||||||::|:.|||:|||||||||||||..|:||:|||||||||||||||.||
 Frog   781 ICIVLNTLFMAMEHYPMTKEFNDVLSIGNLVFTGIFTAEMVFKLIALDPYYYFQEGWNIFDGIIV 845

Human   832 SLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFA 896
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   846 SLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFA 910

Human   897 VVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLT 961
            ||||||||||||||||||:.:||||||||:||||||||||||||||||||||||||||||:|||.
 Frog   911 VVGMQLFGKSYKECVCKIAENCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLL 975

Human   962 VFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQ 1026
            |||:||||||||||||||||||||||||||.|||||||||||||||||:|:|||:||:.|||.||
 Frog   976 VFMLVMVIGNLVVLNLFLALLLSSFSSDNLTATDDDNEMNNLQIAVGRIQRGIDYVKKTIRECIQ 1040

Human  1027 KAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESD 1091
            ||||:|||.||||||||:|:||::||:.||..:||.|.|:|.|..||||||:|||||||::||:|
 Frog  1041 KAFVKKQKGLDEIKPLEELHNKRESCLFNHNAVEINKVLDYHKGDNGTTSGVGSSVEKYIIDEND 1105

Human  1092 YMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAP----- 1151
            |||||:|||||||||||||||||||||||:||||||:||||||||.|||||||||||..|
 Frog  1106 YMSFIHNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNMTSSSEGSTVDIRPPGVVAE 1170

Human  1152 AEGEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVF 1216
            .|||..::|.||:|||:|||||.||::|..|.::|||.||||||..|||||.|||||||||||:|
 Frog  1171 GEGEPIDIESEEALEPDACFTEGCVKRFPICYVNIEENKGKLWWTFRKTCYTIVEHNWFETFIIF 1235

Human  1217 MILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLI 1281
            ||||||||||||||||||||||||||||||||||||||||||||||||||..|||||||||||||
 Frog  1236 MILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFLI 1300

Human  1282 VDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLI 1346
            ||||||||.||||||||||||||||||||||||||||||||||||||||:|||||||||||||||
 Frog  1301 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLI 1365

Human  1347 FWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLG 1411
            ||||||||||||||||:|||:|.|||||...:.|||.|:|   :..|::||||||||||||||.|
 Frog  1366 FWLIFSIMGVNLFAGKYYHCVNTTTGEMLLDTQVNNRSDC---LHLNESARWKNVKVNFDNVGAG 1427

Human  1412 YLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1476
            ||:|||||||||||||||||||||.||.||:||||||||||||||||||||||||||||||||||
 Frog  1428 YLALLQVATFKGWMDIMYAAVDSRKVEEQPRYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF 1492

Human  1477 NQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILI 1541
            ||||||||||||||||||||||||||||||||||||||||.||:||:||||||||.|||.|||||
 Frog  1493 NQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPPNKYQGLVFDFVTKQAFDIIIMILI 1557

Human  1542 CLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSI 1606
            ||||||||:|||:|||:|.|.|||||||||:||||||:||:||||:|||||||||||||||||||
 Frog  1558 CLNMVTMMIETDEQSQDMENNLYWINLVFIILFTGECILKIISLRHYYFTIGWNIFDFVVVILSI 1622

Human  1607 VGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1671
            ||||||::|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog  1623 VGMFLADMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVM 1687

Human  1672 FIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKD 1736
            |||||||||||||||:|.||||||||||||||||||||||||||||||||||||||.|||||..:
 Frog  1688 FIYAIFGMSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPDCDPQME 1752

Human  1737 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEV 1801
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
 Frog  1753 HPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEV 1817

Human  1802 WEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1866
            |||||||||||||::|||:|||||||||.|||||:||||||||||||||||||||||||||||||
 Frog  1818 WEKFDPDATQFIEYSKLSNFADALDPPLRIAKPNRVQLIAMDLPMVSGDRIHCLDILFAFTKRVL 1882

Human  1867 GESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSI 1931
            ||..||||||:.||||||||||||.||||||:||:|||||:|.:||||.:|:|||::.:||.|.:
 Frog  1883 GEGDEMDALRLPMEERFMASNPSKASYEPITSTLRRKQEELSVVIIQRCFRKYLLRKTIKKASYL 1947

Human  1932 YKKDKGKECDGTPIKEDTLIDKLNENSTPEKTDMTPSTTSPPSYDSVTKPEKEKFEKDKSEKEDK 1996
            |||:| ...:..|||||.:|||||.|||.|||||||||||||||||||||||||.||||:|||:|
 Frog  1948 YKKEK-LGVNSLPIKEDMVIDKLNGNSTTEKTDMTPSTTSPPSYDSVTKPEKEKHEKDKAEKENK 2011

Human  1997 GKDIRESKK 2005
            .||.||:||
 Frog  2012 SKDARENKK 2020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN2A	NP_001035232.1	I. {ECO:0000305}	111..456		297/345 (86%)
		Ion_trans	150..435	CDD:278921	241/285 (85%)
		Na_trans_cytopl	514..630	CDD:288761	95/118 (81%)
		II. {ECO:0000305}	741..1013		246/272 (90%)
		Ion_trans	776..971	CDD:278921	178/195 (91%)
		Na_trans_assoc	997..1203	CDD:284034	154/211 (73%)
		III. {ECO:0000305}	1190..1504		283/314 (90%)
		Ion_trans	1225..1482	CDD:278921	230/257 (89%)
		Na_channel_gate	1474..1526	CDD:240441	49/52 (94%)
		IV. {ECO:0000305}	1513..1811		275/298 (92%)
		Ion_trans	1548..1786	CDD:278921	221/238 (93%)
		GPHH	1798..1853	CDD:293510	50/55 (91%)
scn1a	XP_012826731.1	Ion_trans	150..435	CDD:278921	241/285 (85%)
		Na_trans_cytopl	512..631	CDD:288761	95/119 (80%)
		Ion_trans	790..985	CDD:278921	178/195 (91%)
		Na_trans_assoc	1011..1222	CDD:284034	154/211 (73%)
		Ion_trans	1244..1498	CDD:278921	230/257 (89%)
		Na_channel_gate	1490..1542	CDD:240441	49/52 (94%)
		Ion_trans	1564..1802	CDD:278921	221/238 (93%)
		GPHH	1814..1869	CDD:293510	50/55 (91%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D10241at32523
OrthoFinder	1	1.000				FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	5	4.880