Protein Alignment SCN1A and CCH1

DIOPT Version :8

• Sequence 1: NP_001159435.1
• Gene: SCN1A / 6323
• HGNCID: 10585
• Length: 2009
• Species: Homo sapiens
• Sequence 2: NP_011733.3
• Gene: CCH1 / 853131
• SGDID: S000003449
• Length: 2039
• Species: Saccharomyces cerevisiae
• Alignment Length: 2158
• Identity: 404/2159 (19%)
• Similarity: 706/2159 (33%)
• Gaps: 809/2159 (37%)

Human    13 SFNFFTRESLAAIERRIAEEKAKNPKP------------DKKDD------------DENG----- 48
            ||:.::|.|    .||::...:...:|            |..||            ||.|
Yeast   146 SFSSYSRSS----SRRVSNSPSSTDRPPRSAKVLSLIAADDMDDFEDLQKGFKSAIDEEGLTWLP 206

Human    49 ------PKPNSDL--EAG----KNLPFIY----------GDI--PPE-----MVSEPLE------ 78
                  .:|.||:  :.|    :::|.::          |.|  .||     .|||.||
Yeast   207 QLKSEKSRPVSDVGEDRGEGEQESIPDVHTPNVGASATPGSIHLTPEPAQNGSVSEGLEGSINNS 271

Human    79 ----------DLDPYYINKKTFIVLNKGKAIFRF--------SATSALY-----ILTPFNPLR-K 119
                      .|.|...:|....|:...:.|..|        |....||     :.:|.|||| |
Yeast   272 RKKPSPKFFHHLSPQKEDKDQTEVIEYAEDILDFETLQRKLESRPFVLYGHSLGVFSPTNPLRIK 336

Human   120 IAIKILVHSLFSML---------IMCTILT----NCVFM-TMSNPPDWTKNVEYTFTGIYTFESL 170
            || :.|:|..:|:|         |:..|.|    |.||: ..||   ||....:..:..:|...:
Yeast   337 IA-RFLLHRRYSLLYNTLLTFYAILLAIRTYNPHNVVFLYRFSN---WTDYFIFILSACFTGNDI 397

Human   171 IKIIARGFC------------------------------------LEDF---------------- 183
            .||||.||.                                    |.||
Yeast   398 AKIIAFGFWDDSEMFKAYGREYKSILQRSGIMKLYIYLREKYGRKLIDFIIPFRIISPGEETKYQ 462

Human   184 -------------------------TFLRDPWNWLDFTVITFAYVTEFVDLGNV---SALRTFR- 219
                                     .|.|..||.:|.......::..|:.:.:.   :.:|.|:
Yeast   463 RSSLSTSLTKPYGAKENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKP 527

Human   220 --VLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPP 282
              :||.|:.::|..|:.:|:..|...:.:|.:|..:.|:....|.::|:|:|.|:.|.:|:.:.|
Yeast   528 LAILRILRLVNVDTGMPSILRGLKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNP 592

Human   283 TNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLC----------- 336
            .:.:                     ..:::|.:          |..|:||.:..
Yeast   593 EDPT---------------------DTYQYDMQ----------FCGGYLDPVTKRKQNYIYEDGS 626

Human   337 -GNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM 400
             |:.|....||:...|| :..||..|..|||....:...:|.:|:.:.:.:|...|:.:......
Yeast   627 EGSVSKGFLCPQYSKCV-SNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMDSDEMAAC 690

Human   401 IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATAT 465
            :||::.||:.:.:|:||::||:..::|..|:      |.|:.:|
Yeast   691 LFFIVCIFVLTIWLLNLLIAVLVSSFEIANE------EYKKKKF--------------------- 728

Human   466 ASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIR 530
                                                                             
Yeast   729 ----------------------------------------------------------------- 728

Human   531 RKGFRFSIEGNRLT-YEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDE 594
                   |.|:|.| |..|..:.:.....::.:
Yeast   729 -------IYGSRKTGYVARIVTGYWKYFKLKAN-------------------------------- 754

Human   595 HSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSV 659
                                 :.:..|.||     :.||::       |.|:...|:.::
Yeast   755 ---------------------QTKFPNWSQ-----KGLAIY-------SHVEFIFVILII----- 781

Human   660 PTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTV 724
                                     .:..||                          ||:..:|.
Yeast   782 -------------------------CDIGMR--------------------------ASVKVSTS 795

Human   725 EELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEH 789
            .                       :|:...||....:::|:   |::....:.:.|..::
Yeast   796 A-----------------------NCNNILLKTDRGISIVL---FIESLARLVLYLPNMW----- 829

Human   790 YPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 854
                                        |.:....|.|         .||:::..:.:....|||
Yeast   830 ----------------------------KFLTKPSYVY---------DFIISIITLVISCLAVEG 857

Human   855 --------LSVL---RSFRLLRVFKLAKS-WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 907
                    ||:.   |.:|::..|.|.|. |.      :|:.|.| .:.||:.......|:.|::
Yeast   858 VLGHMYAWLSIFHISRFYRVIISFNLTKKLWK------QILSNGV-MIWNLSSFYFFFTFLVAII 915

Human   908 GMQLFGKSYKDCVCKIASDCQLPRWHMND-------FFHSFLIVFRVLCGE-WIETMWDCME--- 961
            ....|             :..:|...|.|       ..:|||.:|.:...| |.:.::...:
Yeast   916 MAVYF-------------EGVIPPEEMADQPFGMYSLPNSFLSLFIIGSTENWTDILYALQKHSP 967

Human   962 -VAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAY 1025
             ::....|...|::..::.|.|:||:|:||:..|...       .:.|....||    .|    |
Yeast   968 NISSTFFCSVFFIIWFLLSNSVILNIFIALISESMEV-------KEEEKRPQQI----KH----Y 1017

Human  1026 VK----RKIYEFIQQSFIR--KQKILDEIKPLDDLNNK----KDSCMSNHTAEIGKDLD------ 1074
            :|    :||.|:...|.:.  ::|.....:..|..:.|    :.:.:.|....:|:..|
Yeast  1018 LKFVYPQKIQEYTHASLVARIRKKFFGGHRNEDTRDFKQFLMRGTAIMNIAQNMGELADEFKEPP 1082

Human  1075 ----YLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSE 1135
                :.|.::..|.|:   .|:::       ...|.|||...        .||.....|.|.:..
Yeast  1083 SENLFKKGLSKLTIGV---PSLKR-------LRMFANNPFYK--------NSDVVFTETNDINGR 1129

Human  1136 SDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVE-PEETLEPEACFTEGCVQRFKCCQINVEEG 1199
            :.:.|    |||    .|...:|.   :::.|:.. ......|:..|     :||  ||..|...
Yeast  1130 TYILE----LNE----YEDEKLDY---LKKYPLFNYSYYFFSPQHRF-----RRF--CQRLVPPS 1176

Human  1200 RGKQ------------WWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTML 1252
            .||:            .:| :|:.|..:|.:.|    ||:..|::..|.....|:.....:...:
Yeast  1177 TGKRTDGSRFFEDSTDLYN-KRSYFHHIERDVF----VFIFALATILLIVCSCYVTPLYRMHHKM 1236

Human  1253 ------EYADKVFTYIFILEMLLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANALGY- 1306
                  ...|..|...|.:|.::|.||.|:    ..|..|.|.::||.:    |:|:..|.:.|
Yeast  1237 GTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCV----LISMWINLIAYL 1297

Human  1307 ---SELGAIKSLRTLRALRPLRALSRFEGMRVVVN-ALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1367
               ..|..|  .:.|.|||.||.|:.....|...| .:...:..|....|:.|.....|::.|::
Yeast  1298 KNNGNLSRI--FKGLTALRALRCLTISNTARQTFNLVMFDGLNKIFEAGLISLSLLFPFTVWGLS 1360

Human  1368 LFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARW--------KNVKVNFDNVGFGYLS 1424
            :|.|:...|.:.:.|          ..||..... |...:|        :...::.|:....:.|
Yeast  1361 IFKGRLGTCNDGSLG----------RADCYNEYS-NSVFQWDIMSPRVYQQPYLHLDSFASAFSS 1414

Human  1425 LLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1489
            |.|:.:.:||:|::...::|..:........|....|:.|:|......|.||||:..|::|   |
Yeast  1415 LYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVLFNFLSMVFILNLFVSFIVNN---Q 1476

Human  1490 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIP------------------------------ 1524
            .:..|  ..:.|.|:|.:..:.|.|...|| |.||
Yeast  1477 ARTTG--SAYFTIEEKAWLESQKLLSQAKP-KAIPNLIELSRVRQFFYQLAVEKKNFYYASFLQV 1538

Human  1525 --------------RPGN--KFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTIL 1573
                          .|||  .:||:.|.|.| .||.|...:.:|         .:....|.....
Yeast  1539 VLYLHIIMLLSRSYNPGNLIGYQGVYFMFST-SVFLIQEALHMC---------GEGPRLYFRQKW 1593

Human  1574 SRINL-VFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSP---TL 1634
            :.|.| :.|:.|....|...:...||:|.             :|.|.||  |:...|:.|   ||
Yeast  1594 NSIRLSIIIIAFIMNAVAFHVPASHYWFH-------------NIKGFFL--LVIFLFIIPQNDTL 1643

Human  1635 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1699
            ..::..|                      |.|||.:.::.....::..:|||.....|...:...
Yeast  1644 TELLETA----------------------MASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLGS 1686

Human  1700 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIF 1764
            ...|..||.|...|||.||:.:...||:.::|.:..|: |.|.    :..:|...|||:.:....
Yeast  1687 NTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSE-PYCS----SDDNSTYTDCGSETYAYL 1746

Human  1765 FFVSYIIISFLVVVNMYIAVILENFSVATEE--SAEPLSEDDFEMFYEVWEKFDPDATQFMEFEK 1827
            ..:|:.|||..:.|||::::|:.|||.....  |...::..:.:.:.|.|.|||.|.|..:|...
Yeast  1747 LLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSY 1811

Human  1828 LSQFAAALEPPLN 1840
            |.:...:.:.||:
Yeast  1812 LPRIMHSFDGPLS 1824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN1A	NP_001159435.1	I. {ECO:0000305}	110..454		93/454 (20%)
		Ion_trans	127..433	CDD:306908	81/415 (20%)
		Na_trans_cytopl	510..705	CDD:314757	16/196 (8%)
		II. {ECO:0000305}	750..1022		53/296 (18%)
		Ion_trans	767..980	CDD:306908	37/237 (16%)
		Na_trans_assoc	1006..1213	CDD:310839	47/240 (20%)
		III. {ECO:0000305}	1200..1514		78/349 (22%)
		Ion_trans	1217..1492	CDD:306908	67/298 (22%)
		Na_channel_gate	1484..1536	CDD:240441	19/98 (19%)
		IV. {ECO:0000305}	1523..1821		79/350 (23%)
		Ion_trans	1540..1796	CDD:306908	61/262 (23%)
		S1-S2 loop of repeat IV. {ECO:0000250|UniProtKB:A2APX8}	1561..1571		1/10 (10%)
		S3b-S4 loop of repeat IV. {ECO:0000250|UniProtKB:A2APX8}	1619..1636		7/20 (35%)
		GPHH	1800..1863	CDD:318993	11/42 (26%)
CCH1	NP_011733.3	Ion_trans	486..722	CDD:278921	58/274 (21%)
		Ion_trans	795..1010	CDD:278921	50/310 (16%)
		Ion_trans	1228..1480	CDD:278921	61/272 (22%)
		Ion_trans	1566..1776	CDD:278921	63/262 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_KOG2301
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I511
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.952	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860