Protein Alignment SCN1A and CCH1

DIOPT Version :10

• Sequence 1: NP_001159435.1
• Gene: SCN1A / 6323
• HGNCID: 10585
• Length: 2009
• Species: Homo sapiens
• Sequence 2: NP_011733.3
• Gene: CCH1 / 853131
• SGDID: S000003449
• Length: 2039
• Species: Saccharomyces cerevisiae
• Alignment Length: 2158
• Identity: 404/2158 - (18%)
• Similarity: 706/2158 - (32%)
• Gaps: 809/2158 - (37%)

Human    13 SFNFFTRESLAAIERRIAEEKAKNPKP------------DKKDD------------DENG----- 48
            ||:.::|.|    .||::...:...:|            |..||            ||.|
Yeast   146 SFSSYSRSS----SRRVSNSPSSTDRPPRSAKVLSLIAADDMDDFEDLQKGFKSAIDEEGLTWLP 206

Human    49 ------PKPNSDL--EAG----KNLPFIY----------GDI--PPE-----MVSEPLE------ 78
                  .:|.||:  :.|    :::|.::          |.|  .||     .|||.||
Yeast   207 QLKSEKSRPVSDVGEDRGEGEQESIPDVHTPNVGASATPGSIHLTPEPAQNGSVSEGLEGSINNS 271

Human    79 ----------DLDPYYINKKTFIVLNKGKAIFRF--------SATSALY-----ILTPFNPLR-K 119
                      .|.|...:|....|:...:.|..|        |....||     :.:|.|||| |
Yeast   272 RKKPSPKFFHHLSPQKEDKDQTEVIEYAEDILDFETLQRKLESRPFVLYGHSLGVFSPTNPLRIK 336

Human   120 IAIKILVHSLFSML---------IMCTILT----NCVFM-TMSNPPDWTKNVEYTFTGIYTFESL 170
            || :.|:|..:|:|         |:..|.|    |.||: ..||   ||....:..:..:|...:
Yeast   337 IA-RFLLHRRYSLLYNTLLTFYAILLAIRTYNPHNVVFLYRFSN---WTDYFIFILSACFTGNDI 397

Human   171 IKIIARGFC------------------------------------LEDF---------------- 183
            .||||.||.                                    |.||
Yeast   398 AKIIAFGFWDDSEMFKAYGREYKSILQRSGIMKLYIYLREKYGRKLIDFIIPFRIISPGEETKYQ 462

Human   184 -------------------------TFLRDPWNWLDFTVITFAYVTEFVDLGNV---SALRTFR- 219
                                     .|.|..||.:|.......::..|:.:.:.   :.:|.|:
Yeast   463 RSSLSTSLTKPYGAKENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKP 527

Human   220 --VLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPP 282
              :||.|:.::|..|:.:|:..|...:.:|.:|..:.|:....|.::|:|:|.|:.|.:|:.:.|
Yeast   528 LAILRILRLVNVDTGMPSILRGLKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNP 592

Human   283 TNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLC----------- 336
            .:.:                     ..:::|.:          |..|:||.:..
Yeast   593 EDPT---------------------DTYQYDMQ----------FCGGYLDPVTKRKQNYIYEDGS 626

Human   337 -GNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM 400
             |:.|....||:...|| :..||..|..|||....:...:|.:|:.:.:.:|...|:.:......
Yeast   627 EGSVSKGFLCPQYSKCV-SNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMDSDEMAAC 690

Human   401 IFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATAT 465
            :||::.||:.:.:|:||::||:..::|..|:      |.|:.:|
Yeast   691 LFFIVCIFVLTIWLLNLLIAVLVSSFEIANE------EYKKKKF--------------------- 728

Human   466 ASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIR 530
                                                                             
Yeast   729 ----------------------------------------------------------------- 728

Human   531 RKGFRFSIEGNRLT-YEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDE 594
                   |.|:|.| |..|..:.:.....::.:
Yeast   729 -------IYGSRKTGYVARIVTGYWKYFKLKAN-------------------------------- 754

Human   595 HSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSV 659
                                 :.:..|.||     :.||::       |.|:...|:.::
Yeast   755 ---------------------QTKFPNWSQ-----KGLAIY-------SHVEFIFVILII----- 781

Human   660 PTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTV 724
                                     .:..||                          ||:..:|.
Yeast   782 -------------------------CDIGMR--------------------------ASVKVSTS 795

Human   725 EELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEH 789
            .                       :|:...||....:::|:   |::....:.:.|..::
Yeast   796 A-----------------------NCNNILLKTDRGISIVL---FIESLARLVLYLPNMW----- 829

Human   790 YPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEG 854
                                        |.:....|.|         .||:::..:.:....|||
Yeast   830 ----------------------------KFLTKPSYVY---------DFIISIITLVISCLAVEG 857

Human   855 --------LSVL---RSFRLLRVFKLAKS-WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVV 907
                    ||:.   |.:|::..|.|.|. |.      :|:.|.| .:.||:.......|:.|::
Yeast   858 VLGHMYAWLSIFHISRFYRVIISFNLTKKLWK------QILSNGV-MIWNLSSFYFFFTFLVAII 915

Human   908 GMQLFGKSYKDCVCKIASDCQLPRWHMND-------FFHSFLIVFRVLCGE-WIETMWDCME--- 961
            ....|             :..:|...|.|       ..:|||.:|.:...| |.:.::...:
Yeast   916 MAVYF-------------EGVIPPEEMADQPFGMYSLPNSFLSLFIIGSTENWTDILYALQKHSP 967

Human   962 -VAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAY 1025
             ::....|...|::..::.|.|:||:|:||:..|...       .:.|....||    .|    |
Yeast   968 NISSTFFCSVFFIIWFLLSNSVILNIFIALISESMEV-------KEEEKRPQQI----KH----Y 1017

Human  1026 VK----RKIYEFIQQSFIR--KQKILDEIKPLDDLNNK----KDSCMSNHTAEIGKDLD------ 1074
            :|    :||.|:...|.:.  ::|.....:..|..:.|    :.:.:.|....:|:..|
Yeast  1018 LKFVYPQKIQEYTHASLVARIRKKFFGGHRNEDTRDFKQFLMRGTAIMNIAQNMGELADEFKEPP 1082

Human  1075 ----YLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSE 1135
                :.|.::..|.|:   .|:::       ...|.|||...        .||.....|.|.:..
Yeast  1083 SENLFKKGLSKLTIGV---PSLKR-------LRMFANNPFYK--------NSDVVFTETNDINGR 1129

Human  1136 SDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVE-PEETLEPEACFTEGCVQRFKCCQINVEEG 1199
            :.:.|    |||    .|...:|.   :::.|:.. ......|:..|     :||  ||..|...
Yeast  1130 TYILE----LNE----YEDEKLDY---LKKYPLFNYSYYFFSPQHRF-----RRF--CQRLVPPS 1176

Human  1200 RGKQ------------WWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTML 1252
            .||:            .:| :|:.|..:|.:.|    ||:..|::..|.....|:.....:...:
Yeast  1177 TGKRTDGSRFFEDSTDLYN-KRSYFHHIERDVF----VFIFALATILLIVCSCYVTPLYRMHHKM 1236

Human  1253 ------EYADKVFTYIFILEMLLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANALGY- 1306
                  ...|..|...|.:|.::|.||.|:    ..|..|.|.::||.:    |:|:..|.:.|
Yeast  1237 GTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCV----LISMWINLIAYL 1297

Human  1307 ---SELGAIKSLRTLRALRPLRALSRFEGMRVVVN-ALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1367
               ..|..|  .:.|.|||.||.|:.....|...| .:...:..|....|:.|.....|::.|::
Yeast  1298 KNNGNLSRI--FKGLTALRALRCLTISNTARQTFNLVMFDGLNKIFEAGLISLSLLFPFTVWGLS 1360

Human  1368 LFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARW--------KNVKVNFDNVGFGYLS 1424
            :|.|:...|.:.:.|          ..||..... |...:|        :...::.|:....:.|
Yeast  1361 IFKGRLGTCNDGSLG----------RADCYNEYS-NSVFQWDIMSPRVYQQPYLHLDSFASAFSS 1414

Human  1425 LLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1489
            |.|:.:.:||:|::...::|..:........|....|:.|:|......|.||||:..|::|   |
Yeast  1415 LYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVLFNFLSMVFILNLFVSFIVNN---Q 1476

Human  1490 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIP------------------------------ 1524
            .:..|  ..:.|.|:|.:..:.|.|...|| |.||
Yeast  1477 ARTTG--SAYFTIEEKAWLESQKLLSQAKP-KAIPNLIELSRVRQFFYQLAVEKKNFYYASFLQV 1538

Human  1525 --------------RPGN--KFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTIL 1573
                          .|||  .:||:.|.|.| .||.|...:.:|         .:....|.....
Yeast  1539 VLYLHIIMLLSRSYNPGNLIGYQGVYFMFST-SVFLIQEALHMC---------GEGPRLYFRQKW 1593

Human  1574 SRINL-VFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSP---TL 1634
            :.|.| :.|:.|....|...:...||:|.             :|.|.||  |:...|:.|   ||
Yeast  1594 NSIRLSIIIIAFIMNAVAFHVPASHYWFH-------------NIKGFFL--LVIFLFIIPQNDTL 1643

Human  1635 FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREV 1699
            ..::..|                      |.|||.:.::.....::..:|||.....|...:...
Yeast  1644 TELLETA----------------------MASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLGS 1686

Human  1700 GIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIF 1764
            ...|..||.|...|||.||:.:...||:.::|.:..|: |.|.    :..:|...|||:.:....
Yeast  1687 NTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSE-PYCS----SDDNSTYTDCGSETYAYL 1746

Human  1765 FFVSYIIISFLVVVNMYIAVILENFSVATEE--SAEPLSEDDFEMFYEVWEKFDPDATQFMEFEK 1827
            ..:|:.|||..:.|||::::|:.|||.....  |...::..:.:.:.|.|.|||.|.|..:|...
Yeast  1747 LLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSY 1811

Human  1828 LSQFAAALEPPLN 1840
            |.:...:.:.||:
Yeast  1812 LPRIMHSFDGPLS 1824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN1A	NP_001159435.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..60		12/72 (17%)
		I. /evidence=ECO:0000305	110..454		93/453 (21%)
		Ion_trans	127..433	CDD:459842	81/414 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..529		0/73 (0%)
		Na_trans_cytopl	555..718	CDD:463401	10/162 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..627		3/42 (7%)
		II. /evidence=ECO:0000305	750..1022		53/295 (18%)
		Ion_trans	767..980	CDD:459842	37/236 (16%)
		Na_trans_assoc	1006..1213	CDD:461936	46/239 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1129..1163		8/33 (24%)
		III. /evidence=ECO:0000305	1200..1514		78/348 (22%)
		Ion_trans	1217..1492	CDD:459842	67/297 (23%)
		Na_channel_gate	1484..1536	CDD:240441	18/97 (19%)
		IV. /evidence=ECO:0000305	1523..1821		78/349 (22%)
		Ion_trans	1540..1796	CDD:459842	61/261 (23%)
		S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8	1561..1571		1/9 (11%)
		S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8	1619..1636		7/19 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1986..2009
CCH1	NP_011733.3	Ion_trans	<483..722	CDD:459842	58/276 (21%)
		Ion_trans	769..1010	CDD:459842	58/398 (15%)
		Ion_trans	1210..1480	CDD:459842	65/289 (22%)
		Ion_trans	1529..1776	CDD:459842	69/298 (23%)