Protein Alignment SCN1A and cch1

DIOPT Version :10

• Sequence 1: NP_001159435.1
• Gene: SCN1A / 6323
• HGNCID: 10585
• Length: 2009
• Species: Homo sapiens
• Sequence 2: NP_593894.1
• Gene: cch1 / 2542812
• PomBaseID: SPAC6F6.01
• Length: 1854
• Species: Schizosaccharomyces pombe
• Alignment Length: 2054
• Identity: 394/2054 - (19%)
• Similarity: 718/2054 - (34%)
• Gaps: 698/2054 - (33%)

Human    62 PFIYGDIPP-------EMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRK 119
            ||::..:.|       |:.:..|..:.|...|:      ..|:.:             ||:|:.:
pombe   134 PFLFDKLSPYFTHFFSEIYAAVLRVVGPPRANE------TPGRNL-------------PFSPILR 179

Human   120 IAIKILVHSLFSMLIMCTILTNCVFMTM--SNPPDWTKNVEYTFTGI---YTFESLIKIIARGFC 179
               :|..|.|:::.|...|:.:.|.:.:  .:|.|.::.::|....|   ||.|.|:||...||.
pombe   180 ---QIYNHPLYNIFIFVVIVLHAVLLMIRSDDPHDKSQTIDYLIIVIGILYTLEMLLKIYLFGFL 241

Human   180 LE------DF------------TFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRV---LRA 223
            .:      ||            ::||..||.:||..|...::: .:........|.|.:   ||.
pombe   242 YDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFVAIVALWIS-VIGKKQQGIFRLFSMIACLRL 305

Human   224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCI-------QWP 281
            .:.:::....:||:.:|.:|...|..|:....|...:.|::|:|.|..:|..:|:       |:.
pombe   306 TRLLNITRKTETILKSLKESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCVWLGDYGDQYL 370

Human   282 PTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCP 346
            ||......|                       |::.|:        ..:||.    |...:...|
pombe   371 PTGQFCGGH-----------------------WENGIK--------RAYLDK----NGFPSNVNP 400

Human   347 EGYMCVKAG-----RNPNYGYTSFDTFSWAFLSLFRLMTQD-FWENLYQLTLRAAGKTYMIFFVL 405
            .|::|.:..     .||.....|||.|..:...:|.:|:.: |.:.:|.:.......:.::|.:.
pombe   401 RGFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIIS 465

Human   406 VIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHS 470
            ..|| :.:|::|::|||..::.:                                      .:||
pombe   466 AYFL-TLWLMSLVIAVVTSSFID--------------------------------------LQHS 491

Human   471 REPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFR 535
                                            .:.|||            |||..:..||.|
pombe   492 --------------------------------GKNQKE------------QKSVDKHLIRNK--- 509

Human   536 FSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFED 600
                                                                             
pombe   510 ----------------------------------------------------------------- 509

Human   601 NESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVG 665
                                                                             
pombe   510 ----------------------------------------------------------------- 509

Human   666 QLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEES 730
                  :.:|
pombe   510 ------LCEK------------------------------------------------------- 513

Human   731 RQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDH 795
                    |.|.:.| ||            ::.:|..     .:|:|               |..
pombe   514 --------YLFYSNF-IW------------ISFIVAQ-----FVTLC---------------TQT 537

Human   796 FNNVLTVGN--LVFTG----IFTAEMFLKIIAMDPYY--YFQEGWNIFDGFIVTLSLVELGLANV 852
            ::...:..|  |:|..    :..||:.|:..|..|.|  :|:...|:.|..:..|:||.| |.::
pombe   538 YDQTSSTANRYLIFYACVDFLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTL-LPSI 601

Human   853 EGLSV----LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF- 912
            ....|    |..|.:.|:::.....|....:.|::.::...|.||.|.|.|::||.::..::||
pombe   602 RKNPVAFGWLSIFAIARIYRCILLIPYTRKIAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQ 666

Human   913 -----GKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCL-- 969
                 |.|..|.:....:            :.|||.::::|..| |.:.|:     |.||...
pombe   667 DLPNDGDSDDDAISFATT------------YESFLYMYQILTSENWTDVMF-----AIQARLAHL 714

Human   970 -------TVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGV--AY 1025
                   ..|.:..:..|.|||::|:|::..:|     |.::.|.:|..|::.:.|:.:..  ..
pombe   715 HLSWIPGAFFTLWFLFSNNVVLSMFIAVIQVNF-----APSESDLKMEQLKMYLARLLRNYNPFQ 774

Human  1026 VKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTS------ 1084
            ....:...|:::..||.|.:||                :|...:.:| :.:|.....|:
pombe   775 ASLTLNALIKRNGSRKGKTVDE----------------SHYEWLYED-NIIKGFLRVTNIPPKEP 822

Human  1085 ---GIGTGSSVEKYIIDE--SDYMSFI--NNPSLTVTVPIAVG---ESDFENLNTEDFSSESDLE 1139
               .:.|...:.||.:.:  :::..|:  ::|.........:|   |.|. ||.|    :..|::
pombe   823 LKPSLDTSPELSKYSLAKLSNNFKRFVMRDDPFSQAYFKRVIGIRWEKDM-NLKT----AAKDMQ 882

Human  1140 ESKEKLNESSSSSEGSTVDIGAPVEEQP-------VVEPEETLEPEACFTEGCVQRFKCCQINVE 1197
            .:|..:....:..          ::..|       |::|...           ::||  ||..|.
pombe   883 AAKAFVRIKQTEF----------LKNHPKYNDVFWVIKPSNR-----------IRRF--CQRLVM 924

Human  1198 EGRGKQWWNLR--RTCFRIVEHNWFETFIVFMILLSSGALAFEDIY--IDQRKTIKTMLEYA--- 1255
            .|..:::..:.  :..:|::     :.||...||.   |:..|.|.  |.:|..:....::|
pombe   925 PGVNERYGGVEPYQWVYRVI-----QVFIYACILT---AVIIECIATPIYERDHLLNDKQHAWFV 981

Human  1256 --DKVFTYIFILEMLLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKS 1314
              :..|..||.:|..:|.:|.|:    ..|..:.|..:||.::....::|.|....::.|.  ::
pombe   982 WTEVAFATIFTIEAAIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHALLS--RA 1044

Human  1315 LRTLRALRPLRALSRFE-GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCIN 1378
            .|..:|||.||.::..: ..|:..:||:.....|.:..:|.....:.|::...|:|.|..|.|
pombe  1045 FRAFKALRVLRLINLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSC-- 1107

Human  1379 TTTGDRFDIEDVNNHTDCLKLIERNETAR---------WKN-VKVNFDNVGFGYLSLLQVATFKG 1433
                   :.::|.:.:.|  ::|...|..         |.| ...:||......|:|.::|:.:|
pombe  1108 -------NDDNVLSASQC--VLEYASTPNNWEVWAPRVWSNPPDYDFDRFPHALLALFEIASIEG 1163

Human  1434 WMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDI 1498
            |:|||.:.:|......||:...|....::||:|.:....:.|.|||.:||.|:.::.     ...
pombe  1164 WVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERT-----GSA 1223

Human  1499 FMTEEQKKYYNAMKKLGSKKPQK-PIPRPGNKFQGMVFDF------VTRQVFDISIMILICLNMV 1556
            |.|.||:.:....:|:.|.:|.| |..||.. .:|:.:||      :.|:.| ..:.|:..|.::
pombe  1224 FFTAEQRAWLELRRKIKSMRPSKRPAIRPLG-LRGLCYDFAVQKHGIWRRTF-TGLYIVHLLFLL 1286

Human  1557 TMMVETDDQSEYVTTILSRINLVFIVL---FTGECVLKLISLRHYYFTIG-WNIFDFVVVILSIV 1617
            |:.........||.      |.:|::|   :|....:|:..|..|||... ||:|| |||.|..:
pombe  1287 TIFYPCPIAYTYVR------NSIFLILSICYTINICVKVYGLSFYYFFHSFWNMFD-VVVTLGSL 1344

Human  1618 GMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1682
            ...:|.|.:....|.||.:...|..:  .:.||........|...::.|||::|:: :..::|::
pombe  1345 TCNIAILAKFENRSLTLLQTTLLVLV--TVHLIPKFDNFDQLSKTVVASLPSIFSL-IATWIVLY 1406

Human  1683 I-YAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKV 1746
            | :||.....|...|..:......||.:..|:::.||.:|...||:.::.....|.     ||.|
pombe  1407 ITFAIAFNQIFGLTKLGLNGGPNKNFRSIRNALVLLFTMTFGEGWNDVMHDYTISY-----PNCV 1466

Human  1747 NPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS-VATEESA-EPLSEDDFEMFY 1809
            |.......||||.......|:::.|||..:.|||:|.|:.:||| :.|:.|: ..|..:||..|.
pombe  1467 NGDDFYNSDCGNKPWAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFTNLQRNDFRQFK 1531

Human  1810 EVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKR 1874
            :.|..|||..|.:                  :|:.|.:                         |.
pombe  1532 DSWAPFDPMVTGY------------------IPKRNAV-------------------------KF 1553

Human  1875 VLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQAS 1939
            ||...|..| .||..:|..:.|..|||.       .|..|:.|..:
pombe  1554 VLSLRGVYD-FRIYRDEHTLRSIISKVQ-------SKTGQQSVPML------------------- 1591

Human  1940 FTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMS 1978
                :|.:.|....|...|.|||.|:.|.:.|:.::..|
pombe  1592 ----ENPLMGSEINLEALDQIIDTIDVNVVKERRNVLNS 1626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SCN1A	NP_001159435.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..60
		I. /evidence=ECO:0000305	110..454		77/382 (20%)
		Ion_trans	127..433	CDD:459842	73/344 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..529		8/73 (11%)
		Na_trans_cytopl	555..718	CDD:463401	1/162 (1%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..627		0/42 (0%)
		II. /evidence=ECO:0000305	750..1022		63/299 (21%)
		Ion_trans	767..980	CDD:459842	50/240 (21%)
		Na_trans_assoc	1006..1213	CDD:461936	36/233 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1129..1163		3/33 (9%)
		III. /evidence=ECO:0000305	1200..1514		76/337 (23%)
		Ion_trans	1217..1492	CDD:459842	71/296 (24%)
		Na_channel_gate	1484..1536	CDD:240441	13/52 (25%)
		IV. /evidence=ECO:0000305	1523..1821		87/310 (28%)
		Ion_trans	1540..1796	CDD:459842	73/261 (28%)
		S1-S2 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8	1561..1571		2/9 (22%)
		S3b-S4 loop of repeat IV. /evidence=ECO:0000250|UniProtKB:A2APX8	1619..1636		5/16 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1986..2009
cch1	NP_593894.1	Ion_trans	184..485	CDD:459842	73/337 (22%)
		Ion_trans	514..748	CDD:459842	63/289 (22%)
		Ion_trans	941..1220	CDD:459842	72/299 (24%)
		Ion_trans	1267..1517	CDD:459842	73/265 (28%)