Protein Alignment Arts and IPO4

DIOPT Version :10

• Sequence 1: NP_001261957.1
• Gene: Arts / 59215
• FlyBaseID: FBgn0042177
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_078934.3
• Gene: IPO4 / 79711
• HGNCID: 19426
• Length: 1081
• Species: Homo sapiens
• Alignment Length: 1085
• Identity: 316/1085 - (29%)
• Similarity: 552/1085 - (50%)
• Gaps: 71/1085 - (6%)

  Fly     1 MEAAILD-IINGILAIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRV 64
            ||:|.|: ::..:|..||||||.:|.::......|.:|..|..::.|....|.||.||||.:||:
Human     1 MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVLTRRRL 65

  Fly    65 KKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYE 129
            .  ..|:.:.||.:.::||.:|..|....|..|..::|.:..::.|.|  ...:| .::|:.:..
Human    66 N--TRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKE--GLEAW-PQLLQLLQH 125

  Fly   130 RCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATP-TVHNMLAGT 193
            ...||...|.|.|..:.|.::.:.|:.|..|...:..||      .|..|.:.:| .:...|...
Human   126 STHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLL------NETLGEVGSPGLLFYSLRTL 184

  Fly   194 CVLLPFISGHSDAEQIMVKAVPLILKALAAF--AEKGNSNEFMGAFDIIDSMAEYVPHLLTGNVK 256
            ..:.|::|  ::...:....||.::.|:...  .::..:.|   |.:.:|.:.|....::|..:.
Human   185 TTMAPYLS--TEDVPLARMLVPKLIMAMQTLIPIDEAKACE---ALEALDELLESEVPVITPYLS 244

  Fly   257 LLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQD----DLK 317
            .:|.|||.:|||.....:||:::|..:..||::|.|.::|.:||.|.|..||.::..:    .|.
Human   245 EVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLD 309

  Fly   318 EGDDDYFSSESL------NSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSF 376
            ..|.| ...|.|      .:|.:.|.|.:|::|||:.|:|..|.|:.:||.||:|..|..|::..
Human   310 PEDQD-SEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGL 373

  Fly   377 ICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILP 441
            :.:.|:::|..:.|.::.|..:|.|:..|:.|....||.||.||||||||.|||.|..::.:::|
Human   374 LVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMP 438

  Fly   442 VLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSNQMR 506
            :|..||..:.|      ..:.|:.:..||||.|.|||...:.||||.||:.:..::...:|.:.:
Human   439 LLLAYLKSVPL------GHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAK 497

  Fly   507 EMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNII 571
            |:|:||:.|::.||:.:|:||||.||..|:..|:.. .:::...:||:::||..|.|.:| :.:.
Human   498 ELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTG-REDLQPVQIQSLETLGVLARAVG-EPMR 560

  Fly   572 PLADETMNFCLMM---LEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSED 633
            |||:|    |..:   |.|..|||:.||..|:|.::||.::.|.:|....:....::.|:.|:|.
Human   561 PLAEE----CCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEG 621

  Fly   634 MVPNVSDNAEDDLALVDAPDIEIDLEHTD----DEDDQD--AYLGENDYIVEKEEAILSLKEFAT 692
            :||.. |.:...|...|..|.|.:.|..|    :|||.:  .|..||.:..|||:...::.|.:.
Human   622 IVPQY-DGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISV 685

  Fly   693 HTGAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKL-------DDAAGLKRACEI 750
            :|..||.||::|.||.|:|:::.|..:||.|..:::..|..||||.       .:.|.|:.|...
Human   686 NTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAALAR 750

  Fly   751 AIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAEL--IFGCIRDIFTNKMACQFNEE 813
            .:|.:...:..:.:..||:.:|:.|..|.:....:..:....|  :.|.::.:...|.|||..:|
Human   751 VVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDE 815

  Fly   814 SGGGDDECSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPEQR 878
            .  .::|..:::|.|.||.|:|....|........:.|:.:|.   .|....:.|.|:.....::
Human   816 E--EEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFA---GFLPLLVCKTKQGCTVAEK 875

  Fly   879 AYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESYPT 943
            ::..|.||:..:.|....|.:...|.|:.::.::::|.:.|.|:.|.:|.:..|....:.|.:|.
Human   876 SFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPK 940

  Fly   944 ILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDTVENDVIQKAF 1008
            :|..|...:.||......||||||:|||::.:|...|..|||...|:.||||:|..|...|.:.|
Human   941 LLGLLFPLLARERHDRVRDNICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLF 1005

  Fly  1009 RVLYLKARPSIEAHLEQILAI-TIEASYKKQMPDVETTESAVALI 1052
            ..||..:...:.....::|.| ::..:..|..||   |::|:.|:
Human  1006 SFLYQSSPDQVIDVAPELLRICSLILADNKIPPD---TKAALLLL 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	19/60 (32%)
		KAP95	<304..703	CDD:227540	139/417 (33%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	15/29 (52%)
		HEAT repeat	438..473	CDD:293787	9/34 (26%)
IPO4	NP_078934.3	IBN_N	24..90	CDD:197981	21/67 (31%)
		HEAT 1	348..385		12/36 (33%)
		HEAT repeat	353..381	CDD:293787	9/27 (33%)
		KAP95	<357..>620	CDD:227540	95/274 (35%)
		HEAT 2	390..427		18/36 (50%)
		HEAT repeat	394..424	CDD:293787	15/29 (52%)
		HEAT 3	431..471		14/45 (31%)
		HEAT repeat	435..464	CDD:293787	9/34 (26%)
		HEAT 4	475..513		14/37 (38%)
		HEAT repeat	477..507	CDD:293787	9/29 (31%)
		HEAT repeat	519..551	CDD:293787	10/32 (31%)
		HEAT 5	895..932		8/36 (22%)
		HEAT 6	936..974		15/37 (41%)