Protein Alignment Arts and Ipo4

DIOPT Version :10

• Sequence 1: NP_001261957.1
• Gene: Arts / 59215
• FlyBaseID: FBgn0042177
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_077229.4
• Gene: Ipo4 / 75751
• MGIID: 1923001
• Length: 1082
• Species: Mus musculus
• Alignment Length: 1074
• Identity: 303/1074 - (28%)
• Similarity: 539/1074 - (50%)
• Gaps: 93/1074 - (8%)

  Fly     1 MEAAILD-IINGILAIDTERIRESTAKMLKAYENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRV 64
            ||.|.|: |:..:|..||||||.:|.::.....:|.:|..|..::.:....|.||.||||.:||:
Mouse     1 MEPAGLEQILKELLLPDTERIRRATEQLQTILRDPAALPALFDLLATATDSQIRQFAAVLTRRRL 65

  Fly    65 KKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKG---TVAFIIGSLVRHEEDKQNSWREEILKF 126
            .  ..|:.:..|.:.::||   .||.|::::||..   ::|.:..::.|.|  ....|.:.:...
Mouse    66 N--NRWRRLAPEQRESLKS---LVLTALQKETVHSVSVSLAQLSATIFRKE--GLQGWPQFMNLL 123

  Fly   127 IYERCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLA 191
            .:...||..| |.|.|..:.|.::.:.|:.|..|...:..||         |..::..:...:|.
Mouse   124 QHSTHSSHSP-EKEVGLLLLSVVVSSQPEAFHAHQHELLQLL---------NETLSDVSFPGVLF 178

  Fly   192 GTCVLLPFISGHSDAEQIMV--KAVPLILKALAAF--AEKGNSNEFMGAFDIIDSMAEYVPHLLT 252
            .:...|..|:.:...:.:.:  ..||.::.||...  .::..:.|   |.:.:|.|.|....::.
Mouse   179 YSLRTLTAIARYVRPDDVSLARMLVPKVVTALRTLIPLDEVKACE---ALEALDEMLETELPIIN 240

  Fly   253 GNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC----- 312
            .::..:|.|||.:|:|......:||:||..:..||::|.|.::|.:|:.|.|..||.::.
Mouse   241 PHLSEVLTFCLEVAKNVALGEPLRVRVLCCLTFLVKVKSKALLKNRLVPPLLHALFPLMAAEPPM 305

  Fly   313 ----QDDLKEGDDDYFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRR 373
                .:|....|||........:|.:.|.|.:|::|||:.|:|..|.::.:||.||:|.:|..|:
Mouse   306 GQLDPEDQDSDDDDLEIGLMGETPKHFAVQVVDMLALHLPPEKLCPHVMPMLEEALRSEDPYQRK 370

  Fly   374 SSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQ 438
            :.|:.:.|:::|..:.|.::.|..:|.|:..|:.|....||.||.||||||||.|||.|..::.:
Mouse   371 AGFLVLAVLSDGAGDHIRQRLLYPLLQIVCKGLDDPSQIVRNAALFALGQFSENLQPHISSYSEE 435

  Fly   439 ILPVLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIVPYLPTLMDRLFGVMEPQNSN 503
            ::|:|..||..:.:      .::.|:.:..||||.|.|||...:.||||.||:.:...::..:..
Mouse   436 VMPLLLSYLKSVPM------GNTHHLAKACYALENFVENLGPKVQPYLPELMECMLQPLKNPSKA 494

  Fly   504 QMREMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKD 568
            :.:|:|:|||.|::.||:::|:||||.||.:|:..|:.. .::.:..:||:::||..|.|.|| :
Mouse   495 RTKELAVSAIGAIATAAQDSLLPYFPTIMDLLREFLLTG-HEDFHLVQIQSLETLGVLARALG-E 557

  Fly   569 NIIPLADET----MNFCLMMLEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVI 629
            ::.|||:|.    :..|:.:     |||:.||..|:|.::||.::.|.:....|:....::.|:.
Mouse   558 SMKPLAEECCQLGLGLCIHI-----DDPDVRRCTYSLFAALSGLMGEGLGPYLPQITTLMLLSLR 617

  Fly   630 SSEDMVPNV-----------SDNAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYIVEKEEA 683
            |:|.:||..           ...||::..|:|.     |:|...|:.:...|..||.:..|||:.
Mouse   618 STEGIVPQYDGISSFLLFDDDSEAEEEEELMDE-----DMEEEGDDSEISGYSVENAFFDEKEDT 677

  Fly   684 ILSLKEFATHTGAAFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKLDDAAG----- 743
            ..:|.|.:.:|..||.|::.:.|:.|||:::.|..:||.:..:::..|..||||....:.
Mouse   678 CTALGEISMNTCVAFLPFMDATFDEVYKLLECPHMNVRKSAYEALGQFCCALHKASQRSSSDPSS 742

  Fly   744 ---LKRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHAELIFGC--IRDIFT 803
               |:.:....:|.:...::.:.:..||:.:|:.|..|.:...::..|....|...|  ::.:..
Mouse   743 SPVLQTSLARVMPAYMQAVKVERERPVVMAVLESLTGVLRTCGSLALQPPGRLSELCNVLKAVLQ 807

  Fly   804 NKMACQFNEESGGGDDECSEESENDEMLFENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAK 868
            .|.|||..||.   |||..:::|.|.||.|:|....|:...|.....|:.:|..   |....|.|
Mouse   808 KKTACQDAEED---DDEDDDQAEYDAMLLEHAGEAIPVLAATAGGHAFAPFFAT---FLPLLLCK 866

  Fly   869 VKERDLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQNSYFALGEIVFHS 933
            .|:.....::::..|.||:..:.|....|.:...|.|:.:..:|::|.:.|.|:.|.||.:..|.
Mouse   867 TKQSCTVAEKSFAVGTLAESIQGLGTASAQFVSRLFPVLLNNAREADPEVRSNAIFGLGVLAEHG 931

  Fly   934 EEKSFESYPTILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVLPVWLNHLPLKDDT 998
            ...:.:.:|.:|..|...:.||......||||||:||:::.:|......|||...|..||||:|.
Mouse   932 GCPAQDHFPKLLGLLLPLLARERHDRVRDNICGALARVLMASPVGKTEPQVLATLLRALPLKEDM 996

  Fly   999 VENDVIQKAFRVLYLKARPSIEAHLEQILAITIE 1032
            .|...|...|..|:       :.:.||::.:..|
Mouse   997 EEWLTIGHLFSFLH-------QNNPEQVVDVASE 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	17/60 (28%)
		KAP95	<304..703	CDD:227540	133/422 (32%)
		HEAT repeat	356..384	CDD:293787	9/27 (33%)
		HEAT repeat	397..427	CDD:293787	15/29 (52%)
		HEAT repeat	438..473	CDD:293787	8/34 (24%)
Ipo4	NP_077229.4	IBN_N	24..90	CDD:197981	20/70 (29%)
		HEAT 1	348..385		12/36 (33%)
		KAP95	<353..>620	CDD:227540	94/279 (34%)
		HEAT repeat	353..381	CDD:293787	9/27 (33%)
		HEAT 2	390..427		18/36 (50%)
		HEAT repeat	394..424	CDD:293787	15/29 (52%)
		HEAT 3	431..471		13/45 (29%)
		HEAT repeat	435..464	CDD:293787	8/34 (24%)
		HEAT 4	475..513		14/37 (38%)
		HEAT repeat	477..507	CDD:293787	9/29 (31%)
		HEAT 5	896..933		10/36 (28%)
		HEAT repeat	901..929	CDD:293787	9/27 (33%)
		HEAT 6	937..975		13/37 (35%)
		HEAT repeat	942..972	CDD:293787	12/29 (41%)