Protein Alignment Arts and kap123

DIOPT Version :10

• Sequence 1: NP_001261957.1
• Gene: Arts / 59215
• FlyBaseID: FBgn0042177
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_596729.1
• Gene: kap123 / 2539863
• PomBaseID: SPBC14F5.03C
• Length: 1067
• Species: Schizosaccharomyces pombe
• Alignment Length: 1126
• Identity: 269/1126 - (23%)
• Similarity: 496/1126 - (44%)
• Gaps: 156/1126 - (13%)

  Fly    13 LAIDTERIRESTAKMLKAY-ENPDSLLVLTQIVMSDRPVQERQVAAVLLKRRVKKLRH--WQLVP 74
            :|.||.:|.|:|..:...| :.|.|||.|..|:.:....|.||:||:    ..:||.|  |..|.
pombe    17 IAPDTTQITEATRALETKYLKEPGSLLSLFHIMGTCENPQVRQLAAI----EARKLCHKYWSSVD 77

  Fly    75 AEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREEILKFIYERCSSPDPIES 139
            |:.|..|:||:|.:.:...|..|:.....:|.:|.:.:. .:..|.|
pombe    78 ADVQNQIRSNLLDITLKEPESIVRHAFGRVIAALAKLDL-PEGKWNE------------------ 123

  Fly   140 ERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNMLAGT------CVLLP 198
                 :.:.|:.|..||..:..:....:|..|..|.:.:..:....| |:.:.|      .|.:.
pombe   124 -----LSAFLVQATMDQNDSIREMAVYVLYSIAETVDLDNKLLLDFV-NLFSQTITDSSRTVRVT 182

  Fly   199 FISG--------HSDAEQIM---VKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVPHLLT 252
            .:.|        .||.::::   ...:|.:|..|....:.|:.:.....||:.::.......:::
pombe   183 SVQGLGAIAEVLESDDKKLLHAYRATLPGMLLVLQDVVQVGDVDASKQVFDVFNTFLIASGAIIS 247

  Fly   253 GNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVICQDDLK 317
            ..:..::|....||.:||.|..||...|:|:.|.:|.|.:.:...||.:|.:..|.||..::...
pombe   248 KALGNIIEIITGIANSKQVDDEIRCMALSFIISCIRFKSRKLQALKLGKPLVLTLMEVATEETTD 312

  Fly   318 EGDDDYFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQSPEPVLRRSSFICMGVI 382
            :.|:|        .|:..|.:::||::.|:.|.:...|:.:......|||:...|:::.:.:||.
pombe   313 DIDED--------CPARLALRSIDLLSTHLSPSQVFYPMFEAACAFSQSPQASYRKAALLSIGVA 369

  Fly   383 AEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPTICKFAPQILPVLFDYL 447
            .||.||::... |..:..||..|:.|:.|.||.||..||.|.:..:...:.|...|:||::|:.:
pombe   370 VEGSSESVAGN-LPNIFPIIINGLCDNDMDVRQAALLALSQIAVEIPTEVSKHHAQLLPLVFELM 433

  Fly   448 NQLVLELKVGEPDSKHMDRMFYALETFCENLDE-DIVPYLPTLMDRLFGVMEPQNSNQMREMALS 511
            :  ...:|||:.....:|.:.       |.||: :|..|||.||:||.|::|..::..::....:
pombe   434 S--TQGVKVGKSACNCIDALL-------EGLDKSEISGYLPMLMERLVGLLEFSDTPDIKSCVAA 489

  Fly   512 AIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLAALCRELGKDNIIPLADE 576
            ||.:.:.||:::.:|||.|.|..|..||......|.|..|...:|||.|:...:||...:|..::
pombe   490 AIGSAAFAAQDDFIPYFERTMASLSQCLHTTDDDEGYELRGTVMDTLGAIANAVGKQAFLPYTEQ 554

  Fly   577 TMNFCLMMLEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFIDRIMESVISSEDMVPNVSD- 640
            .:......::  .|....|...:...:.|:.|..|.    |..|::.|:.::..|.|.  :.||
pombe   555 LIQLAYEGIQ--IDHSRLRECSFCFYAVLARVYKEE----FAPFLEHIVPALFKSIDQ--DESDI 611

  Fly   641 --------NAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYI-VEKEEAILSLKEFATHTGA 696
                    .||:...|:|:  :|.:.|..|:|  .:..:|.|..| :|||.|..:|.|...:.||
pombe   612 LSERIGAPTAEEISQLLDS--VETNEEENDEE--LEKAMGVNSAIAMEKEIAADALGEICMYVGA 672

  Fly   697 AFAPYLQSAFENVYKMIDHPQGDVRMACIDSICSFITALHKLDDAAGLKRACEIAIPKFAHIMRT 761
            .|.|||:...|.:.....|....||.:.:.|:....|..:|:.:....:....:.:|       .
pombe   673 PFTPYLEPTVEKLVACTTHFYEGVRKSALSSLWRCATTYYKVCNVPQWQPGLPLKVP-------V 730

  Fly   762 DDQV-----AVVLRMLDVLYDVFKYVPAIN-SQEHAELIFGC----------------------- 797
            .|.|     ||.....|.|.:.::...|.: .:..||.|..|
pombe   731 PDTVKNIFEAVRKCTFDTLEEEYEKTVATDILRNFAESIKTCGPVVLGDDYEKLCEVVMEVLQKQ 795

  Fly   798 ----IRDIFTNKMACQFNEESGGGDDECSEESENDEMLFENAANLFPMFGLTLQ---PELFSLYF 855
                ..|:|.:    .|.||....::|. :::|.|.:|.::|.::.....:.|.   .:.|.:::
pombe   796 HIVQAGDVFDD----DFEEEDIVSNEEV-DDTEQDALLIDSACDVVIALAVALGGSFADSFKVFY 855

  Fly   856 GRLYHFYIQRLAKVKERDLPEQRAYIYGALADCCKALKGCCATYFDALRPIFIAGSRDSDAKARQ 920
            .::..:|:.:..        .:||.....:.:....::.....:...:..:|:|...||:.:.|.
pombe   856 PQIVKYYMSKNG--------NERAMAVACVGEVAGGIESAITPFTRDVFSLFMAALEDSEGEVRS 912

  Fly   921 NSYFALGEIVFHSEEKSFESYPTILQALSEAIVRESVPAAMDNICGAVARLIVTNPDSVPLGQVL 985
            |:.:::|.:...|.|.....|..|||.|.....:|....|:||..|.::|||:.|.:::|:.|||
pombe   913 NAAYSMGLLCQFSTEDLSSEYLNILQKLQPFFTQEVFRTALDNAIGCISRLILHNQNAIPVDQVL 977

  Fly   986 PVWLNHLPLKDDTVENDVIQKAFRVLYLKARPSIEAHLEQILAI--TIEASYKKQMPDVETTESA 1048
            |:..:.||||:|.:||..:......||.:..|.:..||.:::.:  ::.....:|:.| |.....
pombe   978 PIVFSKLPLKEDYLENAPLYHMILALYRQQNPCLVQHLGELIPVFASVLTGSPEQLND-ELRSEL 1041

  Fly  1049 VALIKEIR-------ANYPEL 1062
            ::::|||.       :|||:|
pombe  1042 LSMVKEIAPQYESVVSNYPQL 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	23/63 (37%)
		KAP95	<304..703	CDD:227540	113/409 (28%)
		HEAT repeat	356..384	CDD:293787	6/27 (22%)
		HEAT repeat	397..427	CDD:293787	12/29 (41%)
		HEAT repeat	438..473	CDD:293787	8/34 (24%)
kap123	NP_596729.1	HEAT repeat	42..67	CDD:293787	9/28 (32%)
		KAP95	54..687	CDD:227540	173/691 (25%)
		HEAT repeat	79..113	CDD:293787	9/33 (27%)
		HEAT repeat	123..153	CDD:293787	7/52 (13%)
		HEAT repeat	163..189	CDD:293787	5/26 (19%)
		HEAT repeat	340..371	CDD:293787	7/30 (23%)
		HEAT repeat	383..413	CDD:293787	12/29 (41%)
		HEAT repeat	424..450	CDD:293787	7/27 (26%)
		HEAT repeat	854..882	CDD:293787	3/35 (9%)
		HEAT_EZ	870..921	CDD:463906	9/50 (18%)
		HEAT repeat	894..924	CDD:293787	7/29 (24%)
		HEAT repeat	933..962	CDD:293787	10/28 (36%)