Protein Alignment Arts and sal3

DIOPT Version :10

• Sequence 1: NP_001261957.1
• Gene: Arts / 59215
• FlyBaseID: FBgn0042177
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_588502.1
• Gene: sal3 / 2539387
• PomBaseID: SPCC1840.03
• Length: 1095
• Species: Schizosaccharomyces pombe
• Alignment Length: 1137
• Identity: 251/1137 - (22%)
• Similarity: 441/1137 - (38%)
• Gaps: 190/1137 - (16%)

  Fly     5 ILDIINGILAIDTERIRESTAKMLKA---YENPDSLLVLTQIV--MSDRPVQERQVAAVLLKR-- 62
            :|:::.|:.:.| ..:|....|.|.:   .:..|.||....|:  .|:.|. .|....||.:|
pombe    13 LLNLVQGLSSPD-NTVRNDAEKSLSSDWISQRADLLLNGLAILAYQSEDPA-VRSFCLVLCRRIS 75

  Fly    63 -RV----KKLRHWQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVRHEEDKQNSWREE 122
             |.    .:|..:..:..|.:.:::|.:|...:.....||:..:...|..:.|...|.|..| .|
pombe    76 FRTLPGDSELEVFSSISNESKQSLQSQLLACFVKESVPTVRNKLCDTIAEIARSIYDCQGEW-PE 139

  Fly   123 ILKFIYERCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVH 187
            ::..|:...:|||  ||.| .|:|.:: .:.|...|.....:.||.         ...:|.|::.
pombe   140 LINVIFNAVNSPD--ESFR-ESVFRTI-TSLPRLLSGQDSAVTPLF---------TTGLADPSIR 191

  Fly   188 NML----AGTCVLLPFISGHSDAEQIMVKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYVP 248
            ..:    |.:.|:|.  |..|..:|: :..:|.::..|....:..:|:........|..:||..|
pombe   192 VRISAARAYSAVILE--SKQSTRDQV-IPLLPSLMNILPPLQQDRDSDNLADCLMAITEIAEVFP 253

  Fly   249 HLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFV-----GSLVRLKKKIIMKQKLLQPTLSVLF 308
            .|.....:.::.|.|.|.::|:.|.|.|...|..:     |:....:|......:|:...|.::.
pombe   254 KLFKPIFESVIAFGLGIIKDKELDNSARQAALELLVCFSEGAPAMCRKSSDYTDQLVLQCLLLMT 318

  Fly   309 EVI--CQDDLKE-----GDDDYFSSESLNSPSNAAAQTLDLMALHMVPDKFIPPLLDLLEPALQS 366
            :|.  .:|:.:|     ..||....|| ::....|.|.:|.::..:.....:||....|...:.|
pombe   319 DVAGDPEDEAEELQEWLNTDDLDQDES-DANHVVAEQAMDRLSRKLGGKTILPPSFTWLPRLIPS 382

  Fly   367 PEPVLRRSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVLDSVMFVRTAAFFALGQFSEFLQPT 431
            .:...|.::.:.:..|||| :|.:.||.|..:|:::...:.|....||.||..|:||.|....|.
pombe   383 QKWSERHAALMAISSIAEG-AEKLMKKELSRVLDMVLPLLADPHPRVRWAACNAVGQMSTDFAPD 446

  Fly   432 I-CKFAPQILPVLFDYLNQLVLELKVGEPDSKHMDRMFYALETFCENLDEDIV-PYLPTLMDRLF 494
            : .|:..:||..|..     |||    .|:|:.......|:..|.|..|..:: |||..::.||.
pombe   447 MQVKYPSRILEALVP-----VLE----SPESRVQAHAAAAMVNFSEEADNKVLEPYLDDILQRLL 502

  Fly   495 GVMEPQNSNQMREMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQRIQAIDTLA 559
            .::: .....::|.|::.||.|:.||.:....||..||.:|...|.:...||..:.|.:.::...
pombe   503 TLLQ-SPKRYVQEQAVTTIATVADAAAKKFEKYFDAIMPLLFNVLQQADGKEFRTLRGKTMECAT 566

  Fly   560 ALCRELGKDNIIPLADETMNFC--LMMLEDGPDDPEFRRSIYNLMSSLSSVVNESMASVFPKFID 622
            .:...:||...:|::.|.:...  :.|.....|||:   :.| |:|:...:. ..:.|.|..|:.
pombe   567 LIALAVGKQRFLPVSQELIQILGNIQMGITDSDDPQ---ASY-LISAWGRIC-RVLGSDFVPFLS 626

  Fly   623 RIMESVISSEDMVPNVSDNAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDY----------- 676
            .:|..::                :|....||..|    .|||.|:..|..::.:
pombe   627 SVMPPLL----------------VAATSKPDFTI----IDDEVDESKYSEQDGWEFIPVHGQQVG 671

  Fly   677 -----IVEKEEAILSLKEFATHTGAAFAPYLQSAFENV----YKMIDHPQGDVRMACIDSICSFI 732
                 :.:|..|...|..:|....|.|.||:.....:|    .|...|  ..||.||...|...:
pombe   672 IRTSTLEDKCTATEMLVCYAAELKADFDPYVNEVLTSVVLPGLKFFFH--DGVRSACCKCIPQLL 734

  Fly   733 TA--LHKLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAIN-SQEHAELI 794
            .|  |....|.|.:....|..:.|....::.:..|.::....:..|...: :..:| |....|.:
pombe   735 NARILASNRDPAKVNELWEPILRKLLDHIQNEPSVEMLADYFECFYQSLE-ISGLNLSPSSMEAL 798

  Fly   795 FGCIRDI----FTNKMACQFNEESGGGDDECSEES------ENDEMLFENAANLFPMFGLTLQPE 849
            ...: |:    |.:::. |..||:..||.:..|:.      |||:.|.......|.:. |.:...
pombe   799 VAAV-DLQLKGFISRVQ-QREEEAKNGDIDIEEDEDMILAVENDQNLLNEINKTFSVV-LKIHKT 860

  Fly   850 LFSLYFGRLYHFYIQRLAKVKERDLPEQRAYIYGALADCCKALKGCCA-------------TYFD 901
            .|..::.||               ||....::.|  .|........|.             .|.|
pombe   861 AFCPFWERL---------------LPYMDGFLSG--NDTVAKQWALCMMDDLIEFTGPDSWNYKD 908

  Fly   902 ALRPIFIAGSRDSDAKARQNSYFALGEIVFHSEEKSFESYPTILQALSEAIVRESVPAAMD---- 962
            ...|....|.:.|:.:.||.:.:.:|....|..|...|...:.|.||.:.:   .:|.|.|
pombe   909 HFLPYLAEGIQSSEPEIRQAASYGIGVAAQHGGELYAEICSSALPALFKML---ELPDARDEEQI 970

  Fly   963 ----NICGAVARLIVTNPDSV-PLGQVLPVWLNHLPLKDDTVENDVIQKAFRVLYLKARPSIEAH 1022
                |||.|:.::.......| .|.:|:..|:|.||:..|  |:|.             |.....
pombe   971 YATENICVAICKICRFCSQRVQDLDKVVTYWINTLPVTHD--EDDA-------------PYAYTF 1020

  Fly  1023 LEQILAITIEASYKKQMPDV-----ETTESAV 1049
            |.:::... ..:...|||.:     ||..|.|
pombe  1021 LAELMEQN-HVAVASQMPTIITILAETFASGV 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	15/72 (21%)
		KAP95	<304..703	CDD:227540	101/425 (24%)
		HEAT repeat	356..384	CDD:293787	4/27 (15%)
		HEAT repeat	397..427	CDD:293787	10/29 (34%)
		HEAT repeat	438..473	CDD:293787	9/34 (26%)
sal3	NP_588502.1	KAP95	22..>502	CDD:227540	119/509 (23%)
		Importin_rep_4	273..370	CDD:408579	19/97 (20%)
		HEAT repeat	376..397	CDD:293787	3/20 (15%)
		HEAT_EZ	385..439	CDD:463906	17/54 (31%)
		HEAT	388..>528	CDD:441023	44/150 (29%)
		HEAT repeat	413..441	CDD:293787	9/27 (33%)
		HEAT repeat	451..484	CDD:293787	10/41 (24%)
		KAP95	<490..640	CDD:227540	37/171 (22%)
		HEAT repeat	496..522	CDD:293787	5/26 (19%)
		Importin_rep_6	771..878	CDD:465881	23/125 (18%)
		Importin_rep_5	1010..1061	CDD:465877	12/58 (21%)