Protein Alignment Arts and Karybeta3

DIOPT Version :10

• Sequence 1: NP_001261957.1
• Gene: Arts / 59215
• FlyBaseID: FBgn0042177
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: XP_310308.5
• Gene: Karybeta3 / 1271502
• VectorBaseID: AGAMI1_000332
• Length: 1109
• Species: Anopheles gambiae
• Alignment Length: 1177
• Identity: 252/1177 - (21%)
• Similarity: 468/1177 - (39%)
• Gaps: 221/1177 - (18%)

  Fly    14 AIDTERIRESTAKML--------KAYENPDSLLVLTQI------VMSDRPVQE-RQVAAVLLKRR 63
            |:|.:..::....:|        ||.|..::|...|::      |.:.:..:: |.::||||:|.
Mosquito     3 ALDQDNFQQLMGSLLSTDNDVRTKAEEVYNALPCETKVPHLLGTVQNPQMAEDARMLSAVLLRRL 67

  Fly    64 VKKLRH--WQLVPAEHQAAIKSNMLQVLIAVKEKTVKGTVAFIIGSLVR--HEEDKQNSWREEIL 124
            .....|  ::.:|.|.:..:|..:|..|...:..:::..:..::..:.|  .::|..|.| .|.|
Mosquito    68 FSSEFHEFYEPLPPEARDQLKQQILLTLQQNESGSMRRKICEMVAEVARCLIDDDGNNEW-PEFL 131

  Fly   125 KFIYERCSSPDPIESERGSSIFSSLMDAAPDQFSNHTDTIFPLLAGILVTAEANGNMATPTVHNM 189
            :|::...:|.:....|....||:|:    |..|.|......||:..:.:      ....||....
Mosquito   132 QFLFHCHNSANVQLQEAALRIFASV----PGIFGNQQAQHLPLIKQMFI------KYLEPTSDQE 186

  Fly   190 LA-------GTCVLLPFISGHSDAEQIMVKAVPLILKALAAFAEKGNSNEFMGAFDIIDSMAEYV 247
            :.       |..|||.  ....|.::.....:|.|:...|...|.|:....|   .::..|||.|
Mosquito   187 VRFQAVRAYGAFVLLH--DKEEDVQRQFADLLPQIIMITAESIELGDPQNLM---QLLIDMAEGV 246

  Fly   248 PHLLTGNVKLLLEFCLMIARNKQFDASIRVQVLTFVGSLVRLKKKIIMKQKLLQPTLSVLFEVIC 312
            |......::.:.|.|:.:......:.::|...|..:.||......::.|:.....|..|...:..
Mosquito   247 PKFFRPQLEPIFELCMKVFSTVDMEDNLRHLALEMMVSLAENAPAMVRKRAAKYVTALVPLILQM 311

  Fly   313 QDDLKEGDDDYFSSESL----NSPSNAAAQT-LDLMALHMVPDKFIPPLLDLLEPALQSPEPVLR 372
            ..|| |.||::..|:.:    .|.:|..|:: ||.:|..:.....:|.:::.:...|.||:...|
Mosquito   312 MTDL-EDDDEWSVSDKITEDDTSDNNVIAESALDRLACGLGGKTILPHIVNNIPNMLLSPDWKQR 375

  Fly   373 RSSFICMGVIAEGCSEAIGKKYLEVMLNIIKAGVL----DSVMFVRTAAFFALGQFSEFLQPTI- 432
            .::.:.:....|||     :|.:|.||..|..|||    |....||.||..|:||.:....|..
Mosquito   376 HAALMAISAAGEGC-----QKQMEAMLENIMQGVLKYLVDPHPRVRYAACNAIGQMATDFAPIFE 435

  Fly   433 CKFAPQILPVLFDYLNQLV---LELKVGEPDSKHMDRMFYALETFCENLDEDIVP-YLPTLMDRL 493
            .||..|::|.|.:.|:.:.   ::...|.           ||..|.|:..::|:. ||..:|.:|
Mosquito   436 KKFHEQVIPGLLNLLDDVENPRVQAHAGA-----------ALVNFSEDCPKNILTRYLDAIMAKL 489

  Fly   494 -------FGVMEPQNSNQMREMALSAIAAVSAAAKENLMPYFPRIMTVLQGCLVKDCPKEMYSQR 551
                   |..:..:.:..:.|..::.||:|:...:::.:.|:.|:|..|:..:......|:...|
Mosquito   490 ELILTTKFKELVEKGTKLVLEQVVTTIASVADTTEKDFVVYYDRLMPSLKYIIKNGNTDELKLLR 554

  Fly   552 IQAIDTLAALCRELGKDNIIPLADETMNFCLMMLEDG--PDDPEFRRSIYNLMSSLSSVVNESMA 614
            .:.|:.::.:...:|.:..:..|.:.|:..|....:|  |||......:.:..:.:..::.:.
Mosquito   555 GKTIECVSLIGLAVGAEKFMSDASDVMDMLLKTHTEGDLPDDDPQTSYLISAWARICKILGKQ-- 617

  Fly   615 SVFPKFIDRIMESVISSEDMVPNVSDNAEDDLALVDAPDIEIDLEHTDDEDDQDAYLGENDYIV- 678
              |.:|:..:|..|:.:..|.|.|        ||:|..::: .:|  :|.:.|...|||....|
Mosquito   618 --FEQFLPLVMGPVMRTASMKPEV--------ALLDNDEMQ-GVE--NDSNWQFVNLGEQQNFVI 669

  Fly   679 ------EKEEAILSLKEFATHTGAAFAPYLQSAFENVYKMIDHPQGD-VRMACIDSICSFITALH 736
                  :|..|...|..:|......||.|.:.....:..|:.....| ||.|..:|       |.
Mosquito   670 RTAGLEDKASACEMLVCYARELKEGFANYAEEVVRLMVPMLKFYFHDGVRSAAAES-------LP 727

  Fly   737 KLDDAAGLKRACEIAIPKFAHIMRTDDQVAVVLRMLDVLYDVFKYVPAINSQEHA----ELIFGC 797
            .|.|.|.:|.      ||:...|              .||...:.:.||:|:..|    ||:...
Mosquito   728 YLLDCAKIKG------PKYLEGM--------------WLYICPELLKAIDSEPEADVLTELLHSL 772

  Fly   798 IRDIFTNKMACQFNEE-------------------------------SGGGDDECSEESENDEML 831
            .|.|.|...||..||.                               ..|.:::.:||.:.|..|
Mosquito   773 ARCIETLGAACLSNEAMEEVLKIIDKFMKQHFEKEEKRAQARKEEDYDDGVEEQLAEEDDADIYL 837

  Fly   832 FENAANLFPMFGLTLQPELFSLYFGRLYHFYIQRLAKVKERDLPEQRAYIYGALADCCKALKGCC 896
            ....:::.....:|.: :.|...|.|:...:::.|.........:....|:..|.:....|   |
Mosquito   838 LSRISDIIHSLFVTYK-DAFLPSFQRVVPHFVKLLQATNPWADRQWGLCIFDDLIEYTGPL---C 898

  Fly   897 ATYFDALRPIFIAGS----RDSDAKARQNSYFALGEI-VFHSEEKSFESYPTILQALS---EAIV 953
            ..|    :|.|:...    :|...:.||.:.:..|.: .|..|:.:.    |..||:|   |.|:
Mosquito   899 VQY----QPYFLQPMLEYIKDEQPEVRQAAVYGCGVLGQFGGEQFAV----TCAQAISLLVEVIM 955

  Fly   954 R------ESVPAAMDNICGAVARLI------VTNPDSVPLGQVLPVWLNHLPLKDDTVEN----- 1001
            .      |:|... :|...||.:::      :||||     :::.:|...||:.:|..|.
Mosquito   956 APDSREPENVNPT-ENAISAVTKILKYNNTAITNPD-----EIIALWFTWLPVGEDEDEAVYVYG 1014

  Fly  1002 ---DVIQKAFRVLYLKARPSIEAHLEQILAITIEASYKK--QMPDVETTESAVALIKEIRANYPE 1061
               |:||....|:.    .....:|.:|::|.....|::  .:|..| .|..::::|:|.:| |:
Mosquito  1015 YLCDLIQANHPVIL----GENNVNLPRIVSIIASCFYREAVTVPHPE-AERMLSIVKQIESN-PD 1073

  Fly  1062 LFSKVSN 1068
            ||....|
Mosquito  1074 LFQACIN 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arts	NP_001261957.1	IBN_N	29..90	CDD:197981	17/69 (25%)
		KAP95	<304..703	CDD:227540	98/428 (23%)
		HEAT repeat	356..384	CDD:293787	4/27 (15%)
		HEAT repeat	397..427	CDD:293787	14/33 (42%)
		HEAT repeat	438..473	CDD:293787	7/37 (19%)
Karybeta3	XP_310308.5	KAP95	57..648	CDD:227540	139/635 (22%)
		Importin_rep_4	268..357	CDD:408579	19/89 (21%)
		HEAT repeat	308..345	CDD:293787	10/37 (27%)
		HEAT repeat	355..387	CDD:293787	5/31 (16%)
		HEAT repeat	399..429	CDD:293787	12/29 (41%)
		HEAT repeat	441..468	CDD:293787	7/37 (19%)
		Importin_rep_6	764..872	CDD:465881	18/108 (17%)
		Importin_rep_5	1005..>1043	CDD:465877	9/41 (22%)