DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF9 and dpr21

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001163838.2	Gene:	dpr21 / 8674044	FlyBaseID:	FBgn0260995	Length:	282	Species:	Drosophila melanogaster

Alignment Length:	238	Identity:	52/238 - (21%)
Similarity:	80/238 - (33%)	Gaps:	70/238 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    13 VISQGA--DGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSP 75
            |:.:|.  |......|.|:||..|.   |.|.:.....:    .:.|:|...|..:.:....|:.
  Fly    46 VLDRGPYFDTSATKNVTSLVGITGH---LNCRIKNLGNK----TVSWIRHRDLHLLTVSESTYTS 103

Human    76 RIDPDYVGRVRLQKGA-SLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQ 139
              |..:......|.|. ||||:..::.|.|.|||:|                            .
  Fly   104 --DQRFTSIYNKQTGDWSLQIKFPQLRDSGIYECQV----------------------------S 138

Human   140 ETPPA--VLEVQELEPVT-----------------LRCVARGSPLP--HVTWKLRGKDLG----Q 179
            .|||.  .:....:||:|                 |.||.:..|.|  .|.|....:::.    :
  Fly   139 TTPPVGYTMVFSVVEPITSILGGPEIYIDLGSTVNLTCVIKHLPDPPISVQWNHNNQEINYDSPR 203

Human   180 GQGQVQVQNGT-----LRIRRVERGSSGVYTCQASSTEGSATH 217
            |...|..:.|.     |.|:|.....||.|||..|:....:.:
  Fly   204 GGVSVITEKGDITTSYLLIQRASIADSGQYTCLPSNANSKSVN 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	24/108 (22%)
		IG_like	28..110	CDD:214653	22/82 (27%)
		I-set	136..223	CDD:254352	25/112 (22%)
		Ig	154..220	CDD:143165	20/92 (22%)
		Ig_3	226..305	CDD:290638
		IG_like	233..319	CDD:214653
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
dpr21	NP_001163838.2	Ig	71..149	CDD:299845	22/111 (20%)
		IG_like	71..140	CDD:214653	19/102 (19%)
		IG_like	162..249	CDD:214653	19/85 (22%)
		IGc2	169..242	CDD:197706	19/72 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910