DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and tutl

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	1492	Identity:	385/1492 - (25%)
Similarity:	586/1492 - (39%)	Gaps:	421/1492 - (28%)

- Green bases have known domain annotations that are detailed below.

Human     7 LAVLSLVISQGADGRGKPE-VVSVVGRAGESVVLGCDLLPPAGRPPLHVIEW----LRFGFLLPI 66
            |..|..::::.|.....|| .|.:....||.|:..|.:..|...|..:|::|    ...|..|||
  Fly   115 LVSLLALLAKNAQAHNIPEDAVHITAILGEGVIFNCHVEFPNDHPVPYVLQWDKKVSETGSDLPI 179

Human    67 FIQFGLYSPRIDPDYVGRV-RLQK-----GASLQIEGLRVEDQGWYECRVFFLD----QHIPEDD 121
            :|.:..|...|:..|.||| |:.:     .|||.:..:|..|||||||:|.||:    ||
  Fly   180 YIWYESYPEHIEEGYKGRVSRVSQDSPFGSASLNLTNIRESDQGWYECKVVFLNRDPKQH----- 239

Human   122 FANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQV 186
             .||:|.||.|::||:|..||..::.|...:.:.|.|.|.|:|.|.:.|.   ||.........|
  Fly   240 -KNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSIILNCQADGTPTPEILWY---KDANPVDPSPTV 300

Human   187 ---QNGT-LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLA 247
               .:|| |||..:.....|.|||.|.:.||..:|..::::.|..||:|||.|.|....:.|..:
  Fly   301 GIFNDGTELRISTIRHEDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFS 365

Human   248 CHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPS 312
            |.|:|.|.|:|..|:::...|..::.|:.||.|..||||.:...:|||:|.|.|..:||:..|.|
  Fly   366 CEAKAMPGNVTVRWYREGSPVREVAALETRVTIRKDGSLIINPIKPDDSGQYLCEVTNGIGDPQS 430

Human   313 ASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTE 377
            |||||:|.|||:||..|....||..:.||::|.::::|.|.:|:||||.:.|:..:.........
  Fly   431 ASAYLSVEYPAKVTFTPTVQYLPFRLAGVVQCYIKSSPQLQYVTWTKDKRLLEPYQMKDIVVMAN 495

Human   378 GSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPC-- 440
            |||:....||:..|:|:|||||:.||||.|.|..||::.||||...|:..|.::||..:.:.|
  Fly   496 GSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVRKPPAFTVEPETLYQRKVGDSVEMHCDA 560

Human   441 -SAQGDPPPVVSWTKVGRGLQGQAQVD--------SNSSLILRPLTKEAHGHWECSASNAVARVA 496
             .|:|...|.:.|.:    .:|:...:        |..::.:..|.:|..|:::|..||.||.:.
  Fly   561 LEAEGTERPTIKWQR----QEGEQLTESQRNRIKISGGNITIENLRREDFGYYQCVVSNEVATLM 621

Human   497 TSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGG--YLQRFSVWYTPLAKRPDRMHHDWVS 559
            ..|.:.:.||.||...|::..|......:.|.||:.||  |.|.:::|:.....      :||.:
  Fly   622 AVTQLVIEGTQPHAPYNITGKATESSITLQWLPGYSGGSEYKQDYTIWFREAGV------NDWQT 680

Human   560 LAV-PVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAP---------- 613
            ::| |.|:..:.:.||...|.|:|.|:.:|.||.|..|:::  ....|...||||
  Fly   681 ISVTPSGSTQVTINGLASGTTYEFQVVGRNVLGDGMMSKVM--TVRTLEDAPAAPRNVKAATQPP 743

Human   614 ----GLPPTEI---------------------PPPL-------SPPRGLVAVRTPRGVLLHWDPP 646
                .|.|.|.                     ||.|       .|||.:.......|.|:.|..|
  Fly   744 DSFFQLMPDEADLLAYFDIYFHTDSRGTLVYSPPKLRVKGPKPGPPRNVSVTEVSNGFLITWQSP 808

Human   647 ELVPKRLDGYVLEGRQGSQGWEVLDPA-VAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNT 710
            ......:..|.::.|..:| |:.|:.. :...||:.||..|:....|.||::|          |:
  Fly   809 LERAHIVKFYTIKYRTDAQ-WKTLNRGQIRPEETQYLVKNLVGGRTYYFRVLA----------NS 862

Human   711 ANVSTSGLEV---YPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKR 772
            .....|..||   .|:|.:     .:.:.||||||:.|..||:::|:.|..:.|:    |:|||:
  Fly   863 EKSYESSDEVKFPVPARVK-----HKAITAGVVGGILFFIVAIILSVCAVKICNK----RKRRKQ 918

Human   773 LRQDPPLIFSPT-GKSAAPS-------ALGSGSPDSVAKLKLQGSPVPSLRQSL------LWGDP 823
            .::...:....| .::.|.:       :.||.|...|...|.:.:.:.||...|      :|...
  Fly   919 EKEFNMVACRITDARNIAANNHHLHNRSTGSISSGQVPLKKYKQTRISSLTAILIAILHWIWPPD 983

Human   824 AGT------PSPH-----PDPPSSRGPLPLEPICRGPDGRFVMG--------------------- 856
            ..|      .||:     .|.........:..|.|..|||||:.
  Fly   984 RCTNCHSIYSSPNLEDGDEDDGGGGRRRSVSRIQRSLDGRFVLDVEGVSKLGYSQQTLESGNVDV 1048

Human   857 ---------------------------------------PTVAAPQERS---------------- 866
                                                   |.||:..:.|
  Fly  1049 VDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRRPLVASSSQLSLQSAADSARGFLQGLL 1113

Human   867 ---GREQAEP------------------------------------------------------R 874
               .::.|.|                                                      .
  Fly  1114 KIGAKQSAVPPNSQSYFDEAVSGARYQNVLRPYTSSNNLYGNADRSRPLHINTISGSLSQQQQLY 1178

Human   875 TPAQRLARSFDCS-------------SSSPSGAPQPLCIEDISPVAPPPAAPPSPLPGPGPLLQY 926
            ||: |::|.|..|             ||..||| .|....|:|.|.||.:|..|. .......:|
  Fly  1179 TPS-RISRIFSSSPQQLQPHHQQLLLSSGGSGA-YPTHFSDLSTVYPPNSAERSS-HNLSSRYRY 1240

Human   927 LS--LPFFREMN-------------VDGDWPPLEEPSPAAPPDYMDTRRC--PTSSFL------- 967
            .|  ||..|.:.             ::..:.||:.|||.:...|..::..  |.:.:.
  Fly  1241 YSQELPSLRTIQEETRRQQQQKQHPLEDHFVPLQLPSPPSWRSYYQSQASYRPRTRWYPRHHSRL 1305

Human   968 ---RSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRG 1029
               |..:...:||...|                   :..||..:.||.|.|:|..  .|.|||.|
  Fly  1306 FSNRQQQHEMLSPLPQL-------------------NLNLRNSMNPGGLEASPES--RSSSSGFG 1349

Human  1030 SASF-----------LRPPSTAPSAGGSYLSPAPGDTSSWASGPE----------RWPR------ 1067
            |.:.           |.||..||        |:|...|.:..|.:          .:||
  Fly  1350 SKNTSNHPGSTSEWRLLPPYRAP--------PSPPKHSGYFGGQQAQGQTPHGSYSYPRATTPPY 1406

Human  1068 -REHVVTVSKRRNT----------------SVDENYEWDSEFP---GDMELLETLHLGLASSRLR 1112
             ..|.:.:..|.|.                |||.:||:|...|   ....|.|.|:|.:.:   .
  Fly  1407 TMAHWLEMISRLNAATDSNLPKAPCPVDVGSVDGHYEFDPATPTPSASSMLREDLNLHIDT---H 1468

Human  1113 PEAEPELGVKTPEEGCLLNT---------------AHV---TGPEARCAALREEFLAFRRRR 1156
            |.....||   |..|.||::               ||:   ...|.|..|:||||.|:|:|:
  Fly  1469 PYHHHTLG---PLSGSLLHSHAPYGGGARKQRSLPAHLPRYDNVEVRLQAMREEFYAYRKRQ 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	44/122 (36%)
		IG_like	28..110	CDD:214653	31/91 (34%)
		I-set	136..223	CDD:254352	28/90 (31%)
		Ig	154..220	CDD:143165	23/69 (33%)
		Ig_3	226..305	CDD:290638	30/78 (38%)
		IG_like	233..319	CDD:214653	35/85 (41%)
		Ig	341..404	CDD:299845	23/62 (37%)
		IG_like	431..503	CDD:214653	18/82 (22%)
		Ig	436..500	CDD:143165	15/74 (20%)
		fn3	511..596	CDD:278470	25/87 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626		11/61 (18%)
		FN3	625..715	CDD:238020	22/90 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919		51/322 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988		11/59 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079		21/91 (23%)
		PDZ-binding. /evidence=ECO:0000250	1177..1179
tutl	NP_001303307.1	V-set	137..250	CDD:284989	41/118 (35%)
		IG_like	137..229	CDD:214653	31/91 (34%)
		I-set	253..341	CDD:254352	28/90 (31%)
		IGc2	268..331	CDD:197706	20/65 (31%)
		I-set	346..437	CDD:254352	39/90 (43%)
		Ig	349..437	CDD:299845	37/87 (43%)
		Ig	459..530	CDD:299845	28/70 (40%)
		IG_like	549..628	CDD:214653	18/82 (22%)
		IGc2	551..617	CDD:197706	14/69 (20%)
		FN3	633..725	CDD:238020	28/99 (28%)
		FN3	786..874	CDD:238020	25/98 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7430
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1724
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D151368at33208
OrthoFinder	1	1.000	-	-		FOG0002337
OrthoInspector	1	1.000	-	-		otm40758
orthoMCL	1	0.900	-	-		OOG6_104975
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4797
SonicParanoid	1	1.000	-	-		X1123
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760