DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IGSF9 and Dscam3

DIOPT Version :9

Sequence 1:NP_001128522.1 Gene:IGSF9 / 57549 HGNCID:18132 Length:1179 Species:Homo sapiens
Sequence 2:NP_996226.2 Gene:Dscam3 / 42103 FlyBaseID:FBgn0261046 Length:2087 Species:Drosophila melanogaster


Alignment Length:1350 Identity:263/1350 - (19%)
Similarity:428/1350 - (31%) Gaps:404/1350 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    24 PEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQ 88
            |:|..|  .:|.:....|.....|    :..|:||..|  .|:.....|.:.|      ..:|..
  Fly   347 PQVQIV--NSGGTANFNCTTTGSA----IDAIDWLHNG--KPLQANNALTTGR------DNIRFL 397

Human    89 KGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEV---QE 150
            ..:||.::.:...|:|.|:|.|        |:..|:..     ..:..:..:|.|.::..   |.
  Fly   398 SKSSLLVQNVGRRDRGVYQCLV--------ENQRASAQ-----AMAELKLGDTVPELIYTFIEQN 449

Human   151 LEP---VTLRCVARGSPLPHVTWKLRGKDLGQ-------GQGQVQVQNGT----LRIRRVERGSS 201
            :.|   ::|:|.|.|||.|...|.|..:.:..       ..||....:|.    |.|..|.....
  Fly   450 VRPGPLISLKCSASGSPPPQFAWLLDSQPIMDVSLHHRFAIGQFVDMSGDVISHLNISHVRPDDG 514

Human   202 GVYTCQASSTEGSATHATQLLVLGPPVI-VVPPKNSTVNASQDVSLACHAEAYPA---------- 255
            |:|.|.||::.||..|:.:|.|.|||.: .:.|..:.  |.:|:.:.|....||.          
  Fly   515 GLYKCVASNSMGSVQHSARLNVYGPPYVRAIGPIKAV--AGEDIIVHCPFAGYPVEQIRWEKAHQ 577

Human   256 NLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPD-DAGCYTCVPSNGLLHPPSASAYLTV 319
            .||.|      |.:.::      .:...|.|.:...:|. |.|.|||:..:...........|.|
  Fly   578 ELTTS------NHYELA------SVADGGQLVIKNVEPGRDQGIYTCIVRSRAGEEARRDMQLNV 630

Human   320 LYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKD------------------------ 360
            ..|..:........|..|....|.|.|.:....::.||.||                        
  Fly   631 NSPPVIEPFKFPKNLQEGGRAQITCAVSSGDMPIYFSWKKDDSSIPSSLQITEKKEEFYSLLVFK 695

Human   361 -------GK----------------ALQLDKFPGW------------------------------ 372
                   ||                .||:...|.|                              
  Fly   696 DISARHSGKYTCYASNAAAKVNYTAELQVRVAPRWRYEPMDTAIMLGNTISINCEAEGYPIPTIT 760

Human   373 ---SQG-----------TEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIER 423
               .||           ...||::.|..::..|.|.|...|.:| ||.....|:.:..|..| |:
  Fly   761 WFKGQGKGSKDFKPLSMRNHSLLLNLATDNDEGYYMCQATNEIG-AGLKKTIRINVNEPARF-EQ 823

Human   424 PKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSN----------------SSLI 472
            ............:.:.|.|:||.|..:.||      |...::|.|                |.|.
  Fly   824 SARNISSRRNDPVTLDCHAKGDEPITIGWT------QNNGRIDLNNFRFSIAEMKTEKGVDSQLT 882

Human   473 LRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVAL-PKGANVSWEPGFDG--- 533
            :....:...|.:.|.|.|...| |.......:...|...:::.:..: .:...:||...|||   
  Fly   883 IGHSDRHDSGVYRCIAENPYGR-AEQIIFLAVQERPDTPSHLEIFEVGSRTVKLSWRRPFDGNSP 946

Human   534 --GYLQRFSVWYTPLAKRPDRMH-------HDW----VSLAVP---VGAAH-------LLVPGLQ 575
              .||.::.      |.:..:.|       .||    :::::|   :..::       .:|.||.
  Fly   947 VLSYLVQYQ------ALKYLQSHGSLAAAGGDWNGHVINVSLPSTSISRSYDSDLRESAIVAGLT 1005

Human   576 PHTQYQFSVLAQNKLGSGPFSE-IVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGV 639
            |.|.:...:.|.|::....::| |||...|..||.               :|....|.......:
  Fly  1006 PATTFLIRMQAINEIERSAYTEAIVLKTQEEAPTE---------------APSNVQVQTGGESEL 1055

Human   640 LLHWD--PPELVPKRLDGYVL---EGRQGSQGWEVLDPAVAGT------ETELLVPGLIKDVLYE 693
            ::.|.  |.|.....|.||.:   |.:|......|::.::..|      .|:..:.||.|...|.
  Fly  1056 IVTWQIPPRESWNGELIGYTVNCSEEKQNINFISVVNSSLKSTIVSGWATTKATLRGLRKYSRYA 1120

Human   694 FRLVAFAGSFVSDPSNTANVSTS--GL-EVYPSRTQLPGLLPQ--------PVL---AGVVGGVC 744
            ..:.|. .||.|.|.:.|...|:  |: |..|.......|..|        |.|   .|::.|..
  Fly  1121 VTIRAM-NSFGSGPWSAAIFGTTAEGVPEAAPQNVNCTALSSQSLKISWLEPPLQFHGGIIQGYK 1184

Human   745 FLGVAVLVSILAGCLLNRRRAA----------RRRRKRLRQDPPLIFSPTGKSAAPSAL----GS 795
            .|...::..|.....|..:|.:          :.....:|   .|.::.||...|...|    ..
  Fly  1185 ILYRPIVHQIDFPAKLEIKRTSNLETYLHTLHKASNYSIR---VLAYTATGDGLASHPLFCQTDD 1246

Human   796 GSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVA 860
            ..||:.|.:|.......|:..|.|            .|.:..|.:....:.....||.....|..
  Fly  1247 DVPDAPAAIKAAALTADSILISWL------------TPKNRNGIISHYTVYSREAGRKGQAKTHM 1299

Human   861 APQERSGREQA-EPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPS------PLP 918
            ...:.:|.... |.|:.|:.....|..|:|:..|..:|..:...:.....||...|      ...
  Fly  1300 VRVDENGYPVTFESRSLAENQMYEFWVSASTSVGEGEPTSVIAQATNTRAPARIASFGQVVRKAV 1364

Human   919 GPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPG 983
            |.|.:|:.|:               :..|:|.|   ...||..|                     
  Fly  1365 GTGLVLECLA---------------VGNPTPRA---RWLTRDRP--------------------- 1390

Human   984 AVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSS---GRGSASF----LRPPST-- 1039
                  .|..|.|....:..|:...:.|.|    .|:.|..::   |.....:    ::|||.  
  Fly  1391 ------VTFSPFYEVTNEGNLKIHRVEGSL----SGNYTCTANNLFGSDEIQYQVIAMKPPSAPQ 1445

Human  1040 ----------------APSAGGSYLSPAPGDTSSWASGPERWPRRE------------------H 1070
                            ||..||   :|..|.|.|:.:..|.|...|                  :
  Fly  1446 IIVQYASADSIRVSWDAPDDGG---APLQGYTISYHTAGESWSITELLPENNAFTISGLKCGNQY 1507

Human  1071 VVTVSKRR----NTSVDENYEWD----SEFPGDMELLET----LHLGLAS 1108
            ::.:|...    ..:.:|...|.    |:.|...||:.|    ::|.|:|
  Fly  1508 IIKMSAHNMVGSGVASEEINVWTKGKASQAPNANELIATNATCVNLKLSS 1557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGSF9NP_001128522.1 IG_like 28..110 CDD:214653 18/81 (22%)
Ig strand B 37..41 CDD:409353 0/3 (0%)
Ig strand C 54..58 CDD:409353 1/3 (33%)
Ig strand E 91..95 CDD:409353 2/3 (67%)
Ig 136..223 CDD:472250 28/103 (27%)
Ig strand B 154..158 CDD:409353 1/3 (33%)
Ig strand C 167..171 CDD:409353 0/3 (0%)
Ig strand E 189..193 CDD:409353 2/7 (29%)
Ig strand F 203..208 CDD:409353 2/4 (50%)
Ig_3 226..305 CDD:464046 20/90 (22%)
Ig <341..404 CDD:472250 23/153 (15%)
Ig strand B 341..344 CDD:409353 1/2 (50%)
Ig strand C 353..358 CDD:409353 1/4 (25%)
Ig strand E 378..382 CDD:409353 2/3 (67%)
Ig strand F 392..397 CDD:409353 2/4 (50%)
Ig 418..503 CDD:472250 20/100 (20%)
Ig strand B 436..440 CDD:409570 0/3 (0%)
Ig strand C 449..453 CDD:409570 0/3 (0%)
Ig strand E 469..473 CDD:409570 2/3 (67%)
FN3 482..>717 CDD:442628 57/275 (21%)
Ig strand F 483..488 CDD:409570 1/4 (25%)
Ig strand G 496..499 CDD:409570 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..626 2/19 (11%)
FN3 625..715 CDD:238020 23/100 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..919 30/162 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..988 6/47 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1079 18/110 (16%)
PDZ-binding. /evidence=ECO:0000250 1177..1179
Dscam3NP_996226.2 Ig 38..135 CDD:472250
Ig strand B 56..60 CDD:409353
Ig strand C 69..73 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 113..118 CDD:409353
Ig strand G 126..130 CDD:409353
Ig 246..337 CDD:472250
Ig strand B 264..268 CDD:409353
Ig strand C 277..281 CDD:409353
Ig strand E 303..307 CDD:409353
Ig strand F 317..322 CDD:409353
Ig strand G 330..333 CDD:409353
Ig 341..434 CDD:472250 23/113 (20%)
Ig strand B 358..362 CDD:409353 0/3 (0%)
Ig strand C 371..375 CDD:409353 1/3 (33%)
Ig strand E 400..404 CDD:409353 2/3 (67%)
Ig strand F 414..419 CDD:409353 2/4 (50%)
Ig strand G 427..430 CDD:409353 0/7 (0%)
IgI_4_Dscam 439..536 CDD:409548 27/96 (28%)
Ig strand A' 447..451 CDD:409548 1/3 (33%)
Ig strand B 454..463 CDD:409548 2/8 (25%)
Ig strand C 468..474 CDD:409548 2/5 (40%)
Ig strand C' 476..479 CDD:409548 0/2 (0%)
Ig strand D 487..495 CDD:409548 2/7 (29%)
Ig strand E 499..508 CDD:409548 2/8 (25%)
Ig strand F 515..523 CDD:409548 4/7 (57%)
Ig strand G 526..536 CDD:409548 4/9 (44%)
Ig 539..630 CDD:472250 21/104 (20%)
Ig strand B 556..560 CDD:409353 0/3 (0%)
Ig strand C 569..573 CDD:409353 0/3 (0%)
Ig strand E 594..598 CDD:409353 2/3 (67%)
Ig strand F 609..614 CDD:409353 3/4 (75%)
Ig strand G 623..626 CDD:409353 0/2 (0%)
Ig 633..724 CDD:472250 13/90 (14%)
Ig strand B 651..655 CDD:409353 1/3 (33%)
Ig strand C 665..669 CDD:409353 1/3 (33%)
Ig strand E 690..694 CDD:409353 0/3 (0%)
Ig strand F 704..709 CDD:409353 1/4 (25%)
Ig strand G 717..720 CDD:409353 0/2 (0%)
Ig 728..815 CDD:472250 15/87 (17%)
Ig strand B 745..749 CDD:409353 0/3 (0%)
Ig strand C 758..762 CDD:409353 0/3 (0%)
Ig strand E 780..784 CDD:409353 2/3 (67%)
Ig strand F 794..799 CDD:409353 2/4 (50%)
Ig strand G 808..811 CDD:409353 0/2 (0%)
Ig 820..913 CDD:472250 20/100 (20%)
Ig strand C 849..853 CDD:409353 0/3 (0%)
Ig strand E 879..883 CDD:409353 2/3 (67%)
Ig strand F 893..898 CDD:409353 1/4 (25%)
Ig strand G 906..909 CDD:409353 0/2 (0%)
FN3 <940..1417 CDD:442628 107/562 (19%)
Ig 1355..1430 CDD:472250 20/123 (16%)
Ig strand B 1368..1372 CDD:409353 1/3 (33%)
Ig strand C 1381..1385 CDD:409353 1/6 (17%)
Ig strand E 1403..1407 CDD:409353 1/3 (33%)
Ig strand F 1417..1422 CDD:409353 1/4 (25%)
Ig strand G 1430..1433 CDD:409353 0/2 (0%)
FN3 1441..1530 CDD:238020 15/91 (16%)
FN3 1542..1620 CDD:238020 5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.