DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF9 and dpr13

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001033956.2	Gene:	dpr13 / 3885598	FlyBaseID:	FBgn0034286	Length:	419	Species:	Drosophila melanogaster

Alignment Length:	206	Identity:	50/206 - (24%)
Similarity:	81/206 - (39%)	Gaps:	57/206 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    54 VIEWLRFG--FLLPIFIQFGLYSPRIDPDY-VGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQ 115
            |:.|:|..  .||.:    ||.:...|..: ...::..:..:|||:.:::.|.|.|||:|   ..
  Fly   206 VVSWIRKKDYHLLTV----GLTTYSSDERFSATHLKHSEDWTLQIKFVQLRDAGVYECQV---ST 263

Human   116 HIPEDDFANGSWVHLTV-------NSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTW--- 170
            |.|...|     :||:|       ..||....||.:.|.:|      .|.|.......::.|
  Fly   264 HPPTSIF-----LHLSVVEARAEITGPPIRYLTPGSTLRLQ------CRVVQNTEASEYIFWYHD 317

Human   171 -KLRGKDLGQG---QGQVQVQNGTLRIRRVERGSSGVYTCQASSTE------------------- 212
             ::...|:.:|   ..:...|:..|.|:|..|..||.:||.||:|:
  Fly   318 NRMINYDIDRGINVSTEPDFQSSELTIQRTRREHSGNFTCVASNTQPASVLVHIFKGDNPAAMYH 382

Human   213 ---GSATHATQ 220
               |.:|..||
  Fly   383 GHVGGSTKTTQ 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	22/80 (28%)
		IG_like	28..110	CDD:214653	16/58 (28%)
		I-set	136..223	CDD:254352	26/114 (23%)
		Ig	154..220	CDD:143165	19/94 (20%)
		Ig_3	226..305	CDD:290638
		IG_like	233..319	CDD:214653
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
dpr13	NP_001033956.2	V-set	180..276	CDD:284989	22/81 (27%)
		IG_like	182..262	CDD:214653	17/62 (27%)
		IG_like	285..362	CDD:214653	22/82 (27%)
		IGc2	292..361	CDD:197706	18/74 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810