DRSC/TRiP Functional Genomics Resources

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Protein Alignment IGSF9 and wrapper

DIOPT Version :10

Sequence 1:NP_001128522.1 Gene:IGSF9 / 57549 HGNCID:18132 Length:1179 Species:Homo sapiens
Sequence 2:NP_477404.1 Gene:wrapper / 37555 FlyBaseID:FBgn0025878 Length:500 Species:Drosophila melanogaster


Alignment Length:526 Identity:118/526 - (22%)
Similarity:179/526 - (34%) Gaps:143/526 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   113 LDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTW------- 170
            |.|...|.||.|      .:.:..:|:..|..| :..|.:.|.|.|.. .:|..:|.|       
  Fly    18 LGQVQAELDFNN------DLENSQKFKSIPTTV-KTYENDTVQLPCTL-NTPFRYVRWHRDDVAL 74

Human   171 -KLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSAT--HATQLLVLGPPVIVVP 232
             ..|..:|......:...||:|::..|:...:|.|.|:.:|..|...  ||.: :.|.|.|::.|
  Fly    75 VDSRHPELPPPDRIMLWPNGSLQVANVQSSDTGDYYCEMNSDSGHVVQQHAIE-VQLAPQVLIEP 138

Human   233 PKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAG 297
            ...:.........:.|.|:..|..: .:| :.|.||     :||:.......||.|.....:.||
  Fly   139 SDLTEQRIGAIFEVVCEAQGVPQPV-ITW-RLNGNV-----IQPQSNTGNRQSLILEIKSRNQAG 196

Human   298 CYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGK 362
            ...||.|||:..|..|:.||.||:..:|:...|.....:|....:.|.|.| .|...|.|...|.
  Fly   197 LIECVASNGVGEPAVANVYLHVLFSPEVSIPQPVVYTKLGSRAHLECIVEA-APAATVKWFHHGL 260

Human   363 ALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEE 427
            .:                        |||.:|.|..:.|.|                  .|..:.
  Fly   261 PV------------------------ALGAHSTTHESELQT------------------NRSVDH 283

Human   428 YFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAV 492
            |...| |.:|:..|.:                        |:.:          |.:||.|||.:
  Fly   284 YVNAV-RHMLVVKSVR------------------------NADM----------GQYECRASNQI 313

Human   493 ARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYT------------- 544
            :..:.|               |.:...|........||.... .....||.|             
  Fly   314 SVKSGS---------------VELTGRPMPCLFKINPGTQSS-TSHVLVWQTESLLPIMEFKLKF 362

Human   545 ---PLAKRPDRMHHDWVSLAVPVGAAHLLV-------PGLQPHTQYQFSVLAQNKLGSGPFSEIV 599
               |......::..:|..|.:|..|.:.|:       .||||.:.|:.||||:|..|....|:||
  Fly   363 RQIPSNNVTRQVRTNWTELTIPAQATNGLIYITTYTLHGLQPASLYEVSVLARNSFGWSDNSKIV 427

Human   600 LSAPEG 605
            ..|..|
  Fly   428 RFATGG 433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGSF9NP_001128522.1 IG_like 28..110 CDD:214653
Ig strand B 37..41 CDD:409353
Ig strand C 54..58 CDD:409353
Ig strand E 91..95 CDD:409353
Ig 136..223 CDD:472250 23/96 (24%)
Ig strand B 154..158 CDD:409353 2/3 (67%)
Ig strand C 167..171 CDD:409353 2/11 (18%)
Ig strand E 189..193 CDD:409353 2/3 (67%)
Ig strand F 203..208 CDD:409353 2/4 (50%)
Ig_3 226..305 CDD:464046 19/78 (24%)
Ig <341..404 CDD:472250 13/62 (21%)
Ig strand B 341..344 CDD:409353 0/2 (0%)
Ig strand C 353..358 CDD:409353 1/4 (25%)
Ig strand E 378..382 CDD:409353 0/3 (0%)
Ig strand F 392..397 CDD:409353 1/4 (25%)
Ig 418..503 CDD:472250 14/84 (17%)
Ig strand B 436..440 CDD:409570 1/3 (33%)
Ig strand C 449..453 CDD:409570 0/3 (0%)
Ig strand E 469..473 CDD:409570 0/3 (0%)
FN3 482..>717 CDD:442628 36/147 (24%)
Ig strand F 483..488 CDD:409570 2/4 (50%)
Ig strand G 496..499 CDD:409570 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..626 118/526 (22%)
FN3 625..715 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..919
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1079
PDZ-binding. /evidence=ECO:0000250 1177..1179
wrapperNP_477404.1 IG_like 41..118 CDD:214653 19/78 (24%)
Ig strand B 52..56 CDD:409353 2/3 (67%)
Ig strand C 64..68 CDD:409353 1/3 (33%)
Ig strand E 94..98 CDD:409353 2/3 (67%)
Ig strand F 108..113 CDD:409353 2/4 (50%)
Ig strand G 122..125 CDD:409353 0/2 (0%)
Ig 133..219 CDD:472250 25/92 (27%)
Ig strand B 150..154 CDD:409353 0/3 (0%)
Ig strand C 163..167 CDD:409353 1/5 (20%)
Ig strand E 183..187 CDD:409353 2/3 (67%)
Ig strand F 197..202 CDD:409353 1/4 (25%)
Ig strand G 211..214 CDD:409353 1/2 (50%)
Ig_3 222..311 CDD:464046 28/166 (17%)
FN3 339..431 CDD:238020 23/92 (25%)
Blue background indicates that the domain is not in the aligned region.

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