DRSC/TRiP Functional Genomics Resources

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Protein Alignment IGSF9 and Dscam1

DIOPT Version :10

Sequence 1:NP_001128522.1 Gene:IGSF9 / 57549 HGNCID:18132 Length:1179 Species:Homo sapiens
Sequence 2:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster


Alignment Length:803 Identity:186/803 - (23%)
Similarity:283/803 - (35%) Gaps:223/803 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    28 SVVGRAGESVV-----LGCDLLPPA-----GRP----------PLHVIEWLRFGFLLPIFIQFGL 72
            ||.|.:.|:|:     |...:.||.     |||          |:..:.|::.|..:      |.
  Fly   331 SVGGESVETVLTVTAPLSAKIDPPTQTVDFGRPAVFTCQYTGNPIKTVSWMKDGKAI------GH 389

Human    73 YSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVN---S 134
            ..|                .|:||.::.||:|.|:|       .:..|..:..:...|.:.   .
  Fly   390 SEP----------------VLRIESVKKEDKGMYQC-------FVRNDQESAEASAELKLGGRFD 431

Human   135 PP----QFQETPPAVLEVQELEP---VTLRCVARGSPLPHVTWKLRGKDLGQGQ----GQVQVQN 188
            ||    .|||        :.:||   |.|:|||.|:|.|.::|:|.||.:....    ||....|
  Fly   432 PPVIRQAFQE--------ETMEPGPSVFLKCVAGGNPTPEISWELDGKKIANNDRYQVGQYVTVN 488

Human   189 GT----LRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACH 249
            |.    |.|..|.....|:|.|.|.|..|.|.|:.:|.|.|.|.|....|.:.| |.:.:.:.|.
  Fly   489 GDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNVYGLPYIRQMEKKAIV-AGETLIVTCP 552

Human   250 AEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPD-DAGCYTCVPSNGLLHPPSA 313
            ...||.: :..|.:|| ....|:|.|   ::..:|:|.:...:.: |...||||..|...:....
  Fly   553 VAGYPID-SIVWERDN-RALPINRKQ---KVFPNGTLIIENVERNSDQATYTCVAKNQEGYSARG 612

Human   314 SAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQ---- 374
            |..:.|:...|:.....|..:.:|....:.|.::.....:.|.|:.:..|...    |:.|    
  Fly   613 SLEVQVMVLPQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDY----GFDQVQPQ 673

Human   375 ------GTEGSLI-IALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEV 432
                  ..:.|:| |...:....|..:|...|..||...|  ..:.:..||.:|..|.::.|.: 
  Fly   674 MRTNRISEKTSMISIPSASPAHTGRDTCIASNKAGTTTYS--VDLTVNVPPRWILEPTDKAFAQ- 735

Human   433 GRELLIPCSAQGDPPPVVSWTK-VG---------------RGLQGQAQVDSNSSLILRPLTKEAH 481
            |.:..:.|.|.|.|.|.|:|.| ||               |..:|...||:        :.|...
  Fly   736 GSDAKVECKADGFPKPQVTWKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDN--------IQKTNE 792

Human   482 GHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALP-----------------------KGA 523
            |::.|.|.|.:            |:....|..:||.|.|                       ||.
  Fly   793 GYYLCEAINGI------------GSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGE 845

Human   524 ----------NVSWEPGFDGGYLQRFSVWYTPL-----AKRPDRMHHDWVSLAVPVGAAHLLVPG 573
                      |:..:|..|..|..|..:..|.:     .||.:|                     
  Fly   846 KPIGILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTER--------------------- 889

Human   574 LQPHTQYQFSVLAQNKLGS--GPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTP 636
               .....|:.:|.|..||  ...:.||...|               |:|..|.     |..::.
  Fly   890 ---SDSALFTCVATNAFGSDDASINMIVQEVP---------------EMPYALK-----VLDKSG 931

Human   637 RGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPA-VAGTETELLVPGLIKDVLYEFRLVAFA 700
            |.|.|.|..|......||.|::|.::....|..:|.. |.|..||..|..|.....|..|:||..
  Fly   932 RSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIVAEN 996

Human   701 GSFVSDPSNTANVSTSGLEVYPS 723
            ....|..|....:.|:  |..||
  Fly   997 AIGTSQSSEAVTIITA--EEAPS 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGSF9NP_001128522.1 IG_like 28..110 CDD:214653 24/101 (24%)
Ig strand B 37..41 CDD:409353 2/8 (25%)
Ig strand C 54..58 CDD:409353 0/3 (0%)
Ig strand E 91..95 CDD:409353 1/3 (33%)
Ig 136..223 CDD:472250 34/101 (34%)
Ig strand B 154..158 CDD:409353 2/3 (67%)
Ig strand C 167..171 CDD:409353 0/3 (0%)
Ig strand E 189..193 CDD:409353 2/7 (29%)
Ig strand F 203..208 CDD:409353 2/4 (50%)
Ig_3 226..305 CDD:464046 21/79 (27%)
Ig <341..404 CDD:472250 13/73 (18%)
Ig strand B 341..344 CDD:409353 0/2 (0%)
Ig strand C 353..358 CDD:409353 1/4 (25%)
Ig strand E 378..382 CDD:409353 2/4 (50%)
Ig strand F 392..397 CDD:409353 1/4 (25%)
Ig 418..503 CDD:472250 24/100 (24%)
Ig strand B 436..440 CDD:409570 0/3 (0%)
Ig strand C 449..453 CDD:409570 1/3 (33%)
Ig strand E 469..473 CDD:409570 0/3 (0%)
FN3 482..>717 CDD:442628 57/275 (21%)
Ig strand F 483..488 CDD:409570 1/4 (25%)
Ig strand G 496..499 CDD:409570 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..626 3/19 (16%)
FN3 625..715 CDD:238020 24/90 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..919
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1079
PDZ-binding. /evidence=ECO:0000250 1177..1179
Dscam1NP_001246162.1 IgI_1_Dscam 38..136 CDD:409547
Ig strand A 39..42 CDD:409547
Ig strand A' 48..52 CDD:409547
Ig strand B 55..64 CDD:409547
Ig strand C 70..76 CDD:409547
Ig strand C' 78..81 CDD:409547
Ig strand D 87..90 CDD:409547
Ig strand E 95..100 CDD:409547
Ig strand F 113..121 CDD:409547
Ig strand G 124..136 CDD:409547
IgI_2_Dscam 246..343 CDD:409545 5/11 (45%)
Ig strand A 247..250 CDD:409545
Ig strand A' 260..264 CDD:409545
Ig strand B 267..274 CDD:409545
Ig strand C 282..288 CDD:409545
Ig strand C' 294..297 CDD:409545
Ig strand D 303..307 CDD:409545
Ig strand E 309..315 CDD:409545
Ig strand F 322..330 CDD:409545
Ig strand G 333..343 CDD:409545 3/9 (33%)
IgC2_3_Dscam 346..426 CDD:409549 21/108 (19%)
Ig strand A 347..352 CDD:409549 1/4 (25%)
Ig strand A' 355..359 CDD:409549 0/3 (0%)
Ig strand B 362..372 CDD:409549 2/9 (22%)
Ig strand C 377..383 CDD:409549 1/5 (20%)
Ig strand C' 384..387 CDD:409549 1/2 (50%)
Ig strand E 392..398 CDD:409549 3/21 (14%)
Ig strand F 405..413 CDD:409549 3/14 (21%)
Ig strand G 416..426 CDD:409549 1/9 (11%)
IgI_4_Dscam 432..527 CDD:409548 35/102 (34%)
Ig strand A 432..435 CDD:409548 2/2 (100%)
Ig strand A' 441..445 CDD:409548 1/11 (9%)
Ig strand B 448..457 CDD:409548 4/8 (50%)
Ig strand C 462..468 CDD:409548 2/5 (40%)
Ig strand C' 470..473 CDD:409548 2/2 (100%)
Ig strand D 478..486 CDD:409548 2/7 (29%)
Ig strand E 490..499 CDD:409548 2/8 (25%)
Ig strand F 506..514 CDD:409548 4/7 (57%)
Ig strand G 517..527 CDD:409548 4/9 (44%)
IgI_5_Dscam 531..618 CDD:409550 23/92 (25%)
Ig strand A 531..533 CDD:409550 1/1 (100%)
Ig strand A' 538..542 CDD:409550 1/3 (33%)
Ig strand B 545..552 CDD:409550 0/6 (0%)
Ig strand C 559..565 CDD:409550 1/6 (17%)
Ig strand C' 566..568 CDD:409550 2/2 (100%)
Ig strand D 575..579 CDD:409550 1/6 (17%)
Ig strand E 582..588 CDD:409550 2/5 (40%)
Ig strand F 596..604 CDD:409550 4/7 (57%)
Ig strand G 608..618 CDD:409550 1/9 (11%)
Ig 621..718 CDD:472250 18/102 (18%)
Ig strand B 639..643 CDD:409353 0/3 (0%)
Ig strand C 653..657 CDD:409353 1/3 (33%)
Ig strand E 684..688 CDD:409353 2/3 (67%)
Ig strand F 698..703 CDD:409353 1/4 (25%)
Ig strand G 711..714 CDD:409353 1/4 (25%)
IgI_7_Dscam 721..815 CDD:409546 27/114 (24%)
Ig strand A 721..725 CDD:409546 2/3 (67%)
Ig strand A' 730..734 CDD:409546 0/3 (0%)
Ig strand B 737..746 CDD:409546 1/8 (13%)
Ig strand C 752..758 CDD:409546 2/5 (40%)
Ig strand C' 764..767 CDD:409546 0/2 (0%)
Ig strand D 775..778 CDD:409546 1/2 (50%)
Ig strand E 780..786 CDD:409546 2/5 (40%)
Ig strand F 793..801 CDD:409546 3/7 (43%)
Ig strand G 806..815 CDD:409546 1/8 (13%)
Ig 818..916 CDD:472250 19/121 (16%)
Ig strand B 836..840 CDD:409353 0/3 (0%)
Ig strand C 849..853 CDD:409353 0/3 (0%)
Ig strand E 880..884 CDD:409353 0/3 (0%)
Ig strand F 894..899 CDD:409353 1/4 (25%)
FN3 <899..1212 CDD:442628 38/141 (27%)
Ig strand G 907..910 CDD:409353 0/2 (0%)
FN3 1222..1312 CDD:238020
Ig <1339..1406 CDD:472250
Ig strand C 1350..1354 CDD:409358
Ig strand E 1372..1376 CDD:409358
Ig strand F 1386..1391 CDD:409358
Ig strand G 1399..1402 CDD:409358
FN3 1409..1499 CDD:238020
FN3 1504..1584 CDD:238020
Dscam_C 1893..2008 CDD:463546
Blue background indicates that the domain is not in the aligned region.

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