DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IGSF9 and dpr18

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	282	Identity:	66/282 - (23%)
Similarity:	89/282 - (31%)	Gaps:	131/282 - (46%)

- Green bases have known domain annotations that are detailed below.

Human   209 SSTEG----SATHATQLLVLGPPVIVVPPKNSTV----NASQDVSLACHAEAYPANLTYSWFQDN 265
            |:|.|    ||.|.....||...|.::  |:.||    ..::.|||..     ..|:|||.
  Fly   225 SATSGDNLVSAVHLFTEAVLNCRVGML--KDKTVMWVRRTAEKVSLLT-----VGNVTYSG---- 278

Human   266 INVFHISRLQPRVRILVD--GSLRLL--ATQPDDAGCYTCVPSNGLLHPPSA-SAYLTVLYPAQV 325
                     .||:|:...  .:.|||  .||.:|||.|.|..|.   |||.. :..||||.|
  Fly   279 ---------DPRIRVKFQYPNNWRLLINPTQTEDAGVYMCQVST---HPPRVFTTNLTVLEP--- 328

Human   326 TAMPPETPLPI---------------GMPGVIRCPV-----------------RANPPL------ 352
                   ||.|               |....::|.:                 .||..:
  Fly   329 -------PLRIIDEHERDVGDRYYKSGSTVDLQCQISRSFFQKERQTILKSTDSANDAVQKLINE 386

Human   353 ----------------------------LFVSWTKDGKALQ------LDKFPGWSQGTEGSLIIA 383
                                        .|::|.||.:.||      |.....|....     |:
  Fly   387 TTSELNLIGNVNQTQHKFSGQDLEKYFTKFITWAKDEEPLQGMTNRRLSVSDVWLTSR-----IS 446

Human   384 LGN---EDALGEYSCTPYNSLG 402
            :|:   .|: |.|||    |||
  Fly   447 IGDAKLSDS-GNYSC----SLG 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845
		IG_like	28..110	CDD:214653
		I-set	136..223	CDD:254352	6/17 (35%)
		Ig	154..220	CDD:143165	6/14 (43%)
		Ig_3	226..305	CDD:290638	24/86 (28%)
		IG_like	233..319	CDD:214653	28/94 (30%)
		Ig	341..404	CDD:299845	21/122 (17%)
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	31/105 (30%)
		Ig	<258..326	CDD:299845	26/88 (30%)
		IGc2	<417..461	CDD:197706	14/53 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900