DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IGSF9 and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	334	Identity:	85/334 - (25%)
Similarity:	135/334 - (40%)	Gaps:	66/334 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     7 LAVLSLVISQGADGRGKPEVVSVVGR----AGESVVLGCDLLPPAGRPPLHVIEWLRFG--FLLP 65
            |.::||:.:.||   .:||.|..:..    .|......|.:....|    :.:.||:..  .:..
  Fly    28 LLIVSLLEAIGA---FQPEFVESISNVSVAVGRDATFTCHVRHLGG----YRVGWLKADTKAIQA 85

Human    66 IFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYEC---------RVFFLDQHIPEDD 121
            |......::||:...::.    |...:|.|:.:..||:|.|.|         ::.|||..||.|.
  Fly    86 IHENVITHNPRVTVSHLD----QNTWNLHIKAVSEEDRGGYMCQLNTDPMKSQIGFLDVVIPPDF 146

Human   122 FANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRG------KD-LGQ 179
            .:               ::|...|: |.|...|.|.|.|||.|.|.|||:...      || :|.
  Fly   147 IS---------------EDTSSDVI-VPEGSSVRLTCRARGYPEPIVTWRREDGNEIVLKDNVGT 195

Human   180 GQGQVQVQNGTLRIRRVERGSSGVYTCQASS-TEGSATHATQLLVLGPPVIVVPPKNSTVNA--S 241
            .......:...|::.::.|...|.|.|.||: ...|.:....|.:...|||.||  |..|.|  .
  Fly   196 KTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQVP--NQLVGAPLG 258

Human   242 QDVSLACHAEAYPANLTYSWFQDNINV------FHISRLQPRVRILVDGSLRLLAT--QPDDAGC 298
            .||.:.||.||.|.::.| |.:|...:      :|:   |...:.:.:..:.::..  |.||.|.
  Fly   259 TDVQIECHVEASPKSINY-WIKDTGEMIVTSGKYHV---QESSQSMYETKMSMIVRKFQKDDVGS 319

Human   299 YTCVPSNGL 307
            |.|:..|.|
  Fly   320 YRCIAKNSL 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	25/122 (20%)
		IG_like	28..110	CDD:214653	16/96 (17%)
		I-set	136..223	CDD:254352	27/94 (29%)
		Ig	154..220	CDD:143165	22/73 (30%)
		Ig_3	226..305	CDD:290638	26/88 (30%)
		IG_like	233..319	CDD:214653	23/85 (27%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	16/87 (18%)
		Ig	51..131	CDD:299845	16/87 (18%)
		I-set	144..240	CDD:254352	28/111 (25%)
		IGc2	159..228	CDD:197706	22/68 (32%)
		Ig	244..337	CDD:299845	28/91 (31%)
		I-set	244..337	CDD:254352	28/91 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810