DRSC/TRiP Functional Genomics Resources

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Protein Alignment IGSF9 and Dscam4

DIOPT Version :10

Sequence 1:NP_001128522.1 Gene:IGSF9 / 57549 HGNCID:18132 Length:1179 Species:Homo sapiens
Sequence 2:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster


Alignment Length:1482 Identity:298/1482 - (20%)
Similarity:460/1482 - (31%) Gaps:555/1482 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    51 PLHVIEWLRFGFLLPIFIQFGLYSPRI----DPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVF 111
            |:|.:.||..|  .||     |...|:    ||           ..|.|:.::.||.|.|:|   
  Fly   357 PVHDVNWLHDG--KPI-----LRDNRVEILTDP-----------PRLIIKKVQKEDPGMYQC--- 400

Human   112 FLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVL---EVQELEP---VTLRCVARGSPLPHVTW 170
                      |.:..|..:...:..|..:..|.:|   ..|.|:|   |:|:|||.|:|||..||
  Fly   401 ----------FVSNEWEQIQSTAELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQFTW 455

Human   171 KLRGKDLGQGQ----GQ-VQVQNGTL---RIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPP 227
            .|.|..:....    || |.:.:..:   .|..|:....|.|||.|.:..|..:|:.::.:.|.|
  Fly   456 SLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYGLP 520

Human   228 VIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQ 292
            .|...||.:.::.| |:.:.|....||.:..: |.:|. ....|:|   |.|...:|:|.:...|
  Fly   521 YIREMPKITGISGS-DLIVKCPVAGYPIDKIH-WERDG-QTLPINR---RQRAYNNGTLIIEQLQ 579

Human   293 P-DDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPET-PLPIGMPGVIRCPV-RANPPLLF 354
            . :|||.|||:..|........:..:.||.|.::..:...| .|..||...|.|.: ..:.|:.|
  Fly   580 RLEDAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISCQILEGDLPVSF 644

Human   355 VSWTKDGKAL---------QLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAG-PSPV 409
             .|.::||.|         :||::       ..||:|...:.|..|.|:|...|..||.. ..|:
  Fly   645 -RWERNGKPLIGTGNEVFRRLDEY-------SASLVIEHISSDHSGNYTCIASNVAGTERFTVPL 701

Human   410 TRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQ---------AQV 465
            |   :..||.:|..||:...| .|.::|:.|.:.|.|.|.::|.|......|:         .|:
  Fly   702 T---VNVPPKWILEPKDSSAQ-AGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQL 762

Human   466 DSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANV----- 525
            ..|.::..:.::||:.||:.|.|.|.:....:......:....|..|....:::.||..|     
  Fly   763 FPNGTIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCN 827

Human   526 ---------SW---------EPGFDGGYLQRFSV------------------------------- 541
                     .|         :...|..|..|..|                               
  Fly   828 VQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFG 892

Human   542 ---------------------------------WYTPLA-KRPDRMHHDWVSLAVPV--GAAHLL 570
                                             |..|.| ..|...:|.:......:  .|.||.
  Fly   893 QDEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLT 957

Human   571 VPG---------LQPHTQYQFSVLAQNKLGSGPFSEIVL-----SAPEGLPTTPAAPGLPPTEI- 620
            :.|         |:|...|...:.|:||||:..|||:|.     ..|.|.|....|.....||| 
  Fly   958 IAGAQTVINIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTLEEVPSGPPLAVRAEPKSSTEIF 1022

Human   621 ----------------------------------------------------------------- 620
                                                                             
  Fly  1023 VTWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTVEVRSHFGGETVLANLNKFTQY 1087

Human   621 -------------PP------------PLSPPRGLVAVRTPR-------GVLLHWDPPELVPKRL 653
                         ||            |.|||      .:|:       .:.:.|.||:      
  Fly  1088 HVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPP------ESPQCDVLGSTSIYITWSPPD------ 1140

Human   654 DGYVLEGRQGS-QGWEVL----------DP-AVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSD 706
                ::|:.|. :|::|.          || .|..|...:.:..|.|...|...::|:  :.|.|
  Fly  1141 ----IDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYVTIENLRKYTNYTVWVLAY--TKVGD 1199

Human   707 PSNTANVSTSGLEVYPSRTQ----LP--------GLLPQPVLAGVVGGVCFLGVAVLVSILAGCL 759
            ...|........|..||..|    :|        ..||..:..|.:.|..|     .:|:|.|  
  Fly  1200 GMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGYTF-----YMSMLEG-- 1257

Human   760 LNRRRAARRRRKRLRQDPPLIFSP---------TGKSA-------APSALGSGSPDSVAKLKLQG 808
             .|.....:|          :..|         |.:||       |.:.:|.|....|..:. ..
  Fly  1258 -GREEGTHKR----------LLGPFVEMHETVRTQESATYQFWLTASTKMGEGEKTQVVTVP-PN 1310

Human   809 SPVP----SLRQSLL--WGD-------PAGTPSP--------HPDPPSSR------GPLPLEPIC 846
            :.||    |..|.::  |.:       ..|.|:|        |....|:|      |.|.::. |
  Fly  1311 NKVPARIVSFSQRIVTPWKEHLELPCRKVGAPAPVTIWRQDGHNMETSARKTIAKNGTLYMKE-C 1374

Human   847 RGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPA 911
            :..|                              |.::.||..:..|..:  .:.:| .|..||.
  Fly  1375 QASD------------------------------AGNYTCSVENTWGKDE--IVYNI-VVKVPPE 1406

Human   912 APPSPL----------------PGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRR 960
            ||...:                .|..|:|.|: :.:.|:   :|||..|:..|... ...:....
  Fly  1407 APNLTVINAYTDSLLLEWMDNSHGGSPILGYV-INYKRD---NGDWEELQVDSKTT-SHLLTNLW 1466

Human   961 CPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGS--LTS 1023
            |.|...|.......:.  ..||..:|.:.....|                   |..|:.|  :|:
  Fly  1467 CGTRYQLYITAYNKIG--TGLPCDIVNSYTKGNP-------------------PVQPKHSQMITN 1510

Human  1024 QSS---------GRGSASFLRPPSTAPSAGGSYL---SPAPGDTSSWASGPERWPRREHVVTVSK 1076
            .|:         |.|....|            |.   |...| .||||......|..|.:.||| 
  Fly  1511 NSTSVTCWLDSWGDGGCGIL------------YFMIESRVYG-RSSWAVVSNHIPPTERIYTVS- 1561

Human  1077 RRNTSVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKT--------PEEGCLLNTA 1133
                         ...||            ...:|:..|....|..|        ..:|.:.|..
  Fly  1562 -------------DLVPG------------TKYQLKVTAHNNAGSTTAIYNFTTLSTQGVIYNND 1601

Human  1134 HVTGPEARCA----------------------ALREEFLAFRRRRDATRARL 1163
            |.| |.:..:                      ||....|..|:|:.|::|||
  Fly  1602 HST-PVSHLSDLPFYANFKLLLPICFSLLMLLALIGAALFLRKRKLASQARL 1652

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGSF9NP_001128522.1 IG_like 28..110 CDD:214653 18/62 (29%)
Ig strand B 37..41 CDD:409353
Ig strand C 54..58 CDD:409353 0/3 (0%)
Ig strand E 91..95 CDD:409353 1/3 (33%)
Ig 136..223 CDD:472250 31/100 (31%)
Ig strand B 154..158 CDD:409353 2/3 (67%)
Ig strand C 167..171 CDD:409353 1/3 (33%)
Ig strand E 189..193 CDD:409353 0/6 (0%)
Ig strand F 203..208 CDD:409353 3/4 (75%)
Ig_3 226..305 CDD:464046 24/79 (30%)
Ig <341..404 CDD:472250 19/72 (26%)
Ig strand B 341..344 CDD:409353 1/2 (50%)
Ig strand C 353..358 CDD:409353 1/4 (25%)
Ig strand E 378..382 CDD:409353 2/3 (67%)
Ig strand F 392..397 CDD:409353 2/4 (50%)
Ig 418..503 CDD:472250 23/93 (25%)
Ig strand B 436..440 CDD:409570 1/3 (33%)
Ig strand C 449..453 CDD:409570 0/3 (0%)
Ig strand E 469..473 CDD:409570 0/3 (0%)
FN3 482..>717 CDD:442628 68/448 (15%)
Ig strand F 483..488 CDD:409570 2/4 (50%)
Ig strand G 496..499 CDD:409570 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..626 8/110 (7%)
FN3 625..715 CDD:238020 22/108 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..919 34/210 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..988 10/47 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1079 19/77 (25%)
PDZ-binding. /evidence=ECO:0000250 1177..1179
Dscam4NP_001261571.1 Ig 31..124 CDD:472250
Ig strand B 50..54 CDD:409353
Ig strand C 63..66 CDD:409353
Ig strand E 82..86 CDD:409353
Ig strand F 102..107 CDD:409353
Ig strand G 115..119 CDD:409353
Ig 235..326 CDD:472250
Ig strand B 253..257 CDD:409353
Ig strand C 266..270 CDD:409353
Ig strand E 292..296 CDD:409353
Ig strand F 306..311 CDD:409353
Ig strand G 319..322 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 20/90 (22%)
Ig strand A 330..335 CDD:409549
Ig strand A' 338..342 CDD:409549
Ig strand B 345..355 CDD:409549
Ig strand C 360..366 CDD:409549 2/5 (40%)
Ig strand C' 367..370 CDD:409549 1/4 (25%)
Ig strand E 383..389 CDD:409549 2/5 (40%)
Ig strand F 396..404 CDD:409549 4/20 (20%)
Ig strand G 407..417 CDD:409549 0/9 (0%)
IgI_4_Dscam 422..516 CDD:409548 30/93 (32%)
Ig strand A' 430..434 CDD:409548 1/3 (33%)
Ig strand B 437..446 CDD:409548 4/8 (50%)
Ig strand C 451..457 CDD:409548 3/5 (60%)
Ig strand C' 459..462 CDD:409548 1/2 (50%)
Ig strand D 467..475 CDD:409548 2/7 (29%)
Ig strand E 479..488 CDD:409548 1/8 (13%)
Ig strand F 495..503 CDD:409548 5/7 (71%)
Ig strand G 506..516 CDD:409548 2/9 (22%)
IgI_5_Dscam 520..607 CDD:409550 25/92 (27%)
Ig strand A 520..522 CDD:409550 1/1 (100%)
Ig strand A' 527..531 CDD:409550 1/3 (33%)
Ig strand B 534..541 CDD:409550 2/7 (29%)
Ig strand C 548..554 CDD:409550 1/6 (17%)
Ig strand C' 555..557 CDD:409550 1/2 (50%)
Ig strand D 564..568 CDD:409550 2/3 (67%)
Ig strand E 571..577 CDD:409550 2/5 (40%)
Ig strand F 585..593 CDD:409550 4/7 (57%)
Ig strand G 597..607 CDD:409550 0/9 (0%)
Ig 610..703 CDD:472250 27/103 (26%)
Ig strand B 629..633 CDD:409353 1/3 (33%)
Ig strand C 643..647 CDD:409353 1/4 (25%)
Ig strand E 669..673 CDD:409353 2/3 (67%)
Ig strand F 683..688 CDD:409353 2/4 (50%)
Ig strand G 696..699 CDD:409353 0/2 (0%)
IgI_7_Dscam 706..801 CDD:409546 24/95 (25%)
Ig strand A 706..710 CDD:409546 2/3 (67%)
Ig strand A' 715..719 CDD:409546 0/3 (0%)
Ig strand B 722..731 CDD:409546 2/8 (25%)
Ig strand C 737..743 CDD:409546 1/5 (20%)
Ig strand C' 749..752 CDD:409546 1/2 (50%)
Ig strand D 760..763 CDD:409546 1/2 (50%)
Ig strand E 766..772 CDD:409546 0/5 (0%)
Ig strand F 779..787 CDD:409546 4/7 (57%)
Ig strand G 792..801 CDD:409546 0/8 (0%)
Ig 804..889 CDD:472250 10/84 (12%)
Ig strand B 822..826 CDD:409353 1/3 (33%)
Ig strand C 835..839 CDD:409353 0/3 (0%)
FN3 <850..1254 CDD:442628 67/426 (16%)
Ig strand F 882..887 CDD:409353 0/4 (0%)
FN3 906..999 CDD:238020 21/92 (23%)
fn3 1117..1203 CDD:394996 21/103 (20%)
FN3 1185..>1580 CDD:442628 94/514 (18%)
FN3 1405..1494 CDD:238020 19/95 (20%)
Blue background indicates that the domain is not in the aligned region.

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