Protein Alignment PTGS2 and cd

DIOPT Version :9

• Sequence 1: NP_000954.1
• Gene: PTGS2 / 5743
• HGNCID: 9605
• Length: 604
• Species: Homo sapiens
• Sequence 2: NP_651081.1
• Gene: cd / 42681
• FlyBaseID: FBgn0263986
• Length: 830
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 118/574 - (20%)
• Similarity: 197/574 - (34%)
• Gaps: 159/574 - (27%)

Human   102 VLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEK 166
            |..::.|    |.||.|          |.:.|.....|...|....| .|....:||.:.::  .
  Fly   224 VCNNKQH----PRTYGA----------SMVPYRRMVSPDYADGIAAP-RVSHHGRLPPARQV--S 271

Human   167 LLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKT--------------------DH----------- 200
            |.:.|..........:|.|.|.|...|....|                    .|
  Fly   272 LKIHRSSYETDSNFTVMLAVFGQFMDHDITATSLTTSQEGESIDCCVAATREQHPECYPVDILPD 336

Human   201 ---------------KRGPAFTNGLGHGVDLNH---------IYGETLARQRKLRLFKDGKMKYQ 241
                           :..||.|...|..:.||.         :||....||.:||.|.:|.::..
  Fly   337 DPYYKQYNISCMNFVRSAPAPTGRFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFINGSLRMF 401

Human   242 II-DGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVF---------GLVPGLMMYATIWLREHN 296
            :. ||....| :....|:.....|:..     :|:..|         .|:  |.....:|.|.||
  Fly   402 VTDDGRQLLP-ISSNPADGCNRVQMTR-----LGKYCFESGDDRANENLL--LTSMHLLWARHHN 458

Human   297 RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKL---------------K 346
            .:...|::::|.|.||:|:|.:|.||..:...|...:::..|.|.:...               .
  Fly   459 YLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDT 523

Human   347 FDPEL------LFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIH-----DQKYNYQQFIYNN-SI 399
            :|||:      .|         .||.|...   |.|||..|.|.     .:.....:.::|. |:
  Fly   524 YDPEVDPSIANCF---------AAAAFRFA---HTLLPGLFNISRDNSTPEAIELHKMLFNPFSL 576

Human   400 LLEHGI------------TQFVESFTRQIAGRVAGGR---NVPPAVQKVSQASIDQSRQMKYQSF 449
            ..||||            .|....|:.::..::..|.   .||.....:...:|.:.|.....|:
  Fly   577 WAEHGIDHALMTAANTPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSY 641

Human   450 NEYRKRFMLKPYESFEELTGEKEMSAELEA---LYGDIDAVELYPALLVEKPRPDAIFGETMVEV 511
            ..:|:...|...:::||::...: :|.|::   :|.....|::|...|.|.|...||||..:..:
  Fly   642 PVFRRHCRLPTVDTWEEMSQAID-NATLDSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCM 705

Human   512 GAPFSLKGLMGNVICSPAYW-----KPSTFGGEVGFQIINTASIQSLICNNVKG 560
            .:...|:..:|:     ::|     .|..|......:|..| |:.::||.|..|
  Fly   706 VSDQFLRLKLGD-----SHWYERKMGPQKFTKAQLAEIYKT-SLAAIICRNSDG 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTGS2	NP_000954.1	EGF_CA	19..54	CDD:238011
		prostaglandin_endoperoxide_synthase	75..562	CDD:188648	118/574 (21%)
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	118/574 (21%)
		peroxinectin_like	364..750	CDD:188655	89/412 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810