Protein Alignment PTGS2 and cd

DIOPT Version :10

• Sequence 1: NP_000954.1
• Gene: PTGS2 / 5743
• HGNCID: 9605
• Length: 604
• Species: Homo sapiens
• Sequence 2: NP_651081.1
• Gene: cd / 42681
• FlyBaseID: FBgn0263986
• Length: 830
• Species: Drosophila melanogaster
• Alignment Length: 574
• Identity: 118/574 - (20%)
• Similarity: 197/574 - (34%)
• Gaps: 159/574 - (27%)

Human   102 VLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEK 166
            |..::.|    |.||.|          |.:.|.....|...|....| .|....:||.:.::  .
  Fly   224 VCNNKQH----PRTYGA----------SMVPYRRMVSPDYADGIAAP-RVSHHGRLPPARQV--S 271

Human   167 LLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKT--------------------DH----------- 200
            |.:.|..........:|.|.|.|...|....|                    .|
  Fly   272 LKIHRSSYETDSNFTVMLAVFGQFMDHDITATSLTTSQEGESIDCCVAATREQHPECYPVDILPD 336

Human   201 ---------------KRGPAFTNGLGHGVDLNH---------IYGETLARQRKLRLFKDGKMKYQ 241
                           :..||.|...|..:.||.         :||....||.:||.|.:|.::..
  Fly   337 DPYYKQYNISCMNFVRSAPAPTGRFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFINGSLRMF 401

Human   242 II-DGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVF---------GLVPGLMMYATIWLREHN 296
            :. ||....| :....|:.....|:..     :|:..|         .|:  |.....:|.|.||
  Fly   402 VTDDGRQLLP-ISSNPADGCNRVQMTR-----LGKYCFESGDDRANENLL--LTSMHLLWARHHN 458

Human   297 RVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKL---------------K 346
            .:...|::::|.|.||:|:|.:|.||..:...|...:::..|.|.:...               .
  Fly   459 YLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDT 523

Human   347 FDPEL------LFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIH-----DQKYNYQQFIYNN-SI 399
            :|||:      .|         .||.|...   |.|||..|.|.     .:.....:.::|. |:
  Fly   524 YDPEVDPSIANCF---------AAAAFRFA---HTLLPGLFNISRDNSTPEAIELHKMLFNPFSL 576

Human   400 LLEHGI------------TQFVESFTRQIAGRVAGGR---NVPPAVQKVSQASIDQSRQMKYQSF 449
            ..||||            .|....|:.::..::..|.   .||.....:...:|.:.|.....|:
  Fly   577 WAEHGIDHALMTAANTPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSY 641

Human   450 NEYRKRFMLKPYESFEELTGEKEMSAELEA---LYGDIDAVELYPALLVEKPRPDAIFGETMVEV 511
            ..:|:...|...:::||::...: :|.|::   :|.....|::|...|.|.|...||||..:..:
  Fly   642 PVFRRHCRLPTVDTWEEMSQAID-NATLDSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCM 705

Human   512 GAPFSLKGLMGNVICSPAYW-----KPSTFGGEVGFQIINTASIQSLICNNVKG 560
            .:...|:..:|:     ::|     .|..|......:|..| |:.::||.|..|
  Fly   706 VSDQFLRLKLGD-----SHWYERKMGPQKFTKAQLAEIYKT-SLAAIICRNSDG 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTGS2	NP_000954.1	EGF_CA	19..54	CDD:238011
		prostaglandin_endoperoxide_synthase	75..562	CDD:188648	118/574 (21%)
cd	NP_651081.1	An_peroxidase	218..762	CDD:460804	118/574 (21%)