DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and SERCA

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster

Alignment Length:	1053	Identity:	312/1053 - (29%)
Similarity:	503/1053 - (47%)	Gaps:	143/1053 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTPQPPTPKWIVFLKTMFGGF--AILL 93
            |.|...|::.|....|||..||:..:.|...:..|||.|..:.....|.:.|: .|...  .|||
  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLE-QFDDLLVKILL 66

  Fly    94 WAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYFQVHKSSSIMDSFKNLVPQYA 158
            .|    ..:.:::.|..:||.........:.:.:::|...:...:|...:.|.:::.|...|:..
  Fly    67 LA----AIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMG 127

  Fly   159 TVIREGE--INTVTSDEIVKGDIVEVKFGDRVPADIRILEAHG--LKVDNSSLTGESEPQVRSTE 219
            .|:|:.:  |..|.:.|||.||:|||..||::||||||...:.  |::|.|.|||||...::.|:
  Fly   128 KVVRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTD 192

  Fly   220 FTHENPL---ETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAGLDDVQSPISREIQLFI 281
            ...:...   :.||:.|..|||..|..|||||.||.||.:|:|....:..:::::|:.:::..|.
  Fly   193 AIPDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFG 257

  Fly   282 RFITIFAIILGLSFFAISL------TLGYEFIDAVVF----LIGIIVANVPEGLLVTVTVCLTLT 336
            ..::....::.::.:||::      ..|..:|...::    .:.:.||.:||||...:|.||.|.
  Fly   258 EQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALG 322

  Fly   337 AKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLW-YDQI------IVESDTTES 394
            .:|||.||.:|::|.:|||||.||.||||||||||.|:|:|:.:: :|::      .:|.:.|.|
  Fly   323 TRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGS 387

  Fly   395 ---------FRGSHFKIED-KSFNALFMCAALCNSA-----EFKGGQDDIPVFKKDVNGNASEAA 444
                     ..|...|..| .:...|.....:||.:     |||...:.:        |.|:|.|
  Fly   388 TYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKV--------GEATETA 444

  Fly   445 LLKFTETI----------------FAGIGAFRQKHIKLTEIPFNSTEKYQVS------VHEFNSS 487
            |:...|.:                .|..|....|..|...:.|:...|...|      .....:.
  Fly   445 LIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTG 509

  Fly   488 DGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFEEAYLEMGGMGE---RVLGFADLLLP 549
            ...|:   |||||.:|:||:...:....|.||..||.:. .|.....|.|.   |.|..|....|
  Fly   510 PKLFV---KGAPEGVLERCTHARVGTTKVPLTSALKAKI-LALTGQYGTGRDTLRCLALAVADSP 570

  Fly   550 MSKYPISYEFSADPPNFPLE-NLRFLGLISLIDPPRAAVPDAVAKCRSAGVRVIMVTGDHPITAK 613
            |.  |...:.......:..| ||.|:|::.::||||..|.|::.:||:||:|||::|||:..||:
  Fly   571 MK--PDEMDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAE 633

  Fly   614 AIARSVGIITTPTAEDIAKQRGVTVLDIDSRQATAIVVHGGELREMKAEELDAVIYYHNEIVFAR 678
            ||.|.:|:.    |||              ...|.....|.|..::...|..|.:  ....:|:|
  Fly   634 AICRRIGVF----AED--------------EDTTGKSYSGREFDDLSPTEQKAAV--ARSRLFSR 678

  Fly   679 TSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAMGISGSDVSKQAADMILLDDNFAS 743
            ..||.|..|||..|...||.|:|||||||:||||:|:||:||| ||:.|:|.||:|:|.||||:|
  Fly   679 VEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSS 742

  Fly   744 IVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIPLALGTIAILCIDIGTDMLPAISL 808
            ||..:||||.|::|:|:.|.|.::||:.|:|.........:|.||..:.:|.:::.||.|||.:|
  Fly   743 IVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATAL 807

  Fly   809 AYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIG------VIQTVACFFTFFAIMAEHGFPPS 867
            .:...:.|||.:.||.. ::.|::..| ...|:.||      .:...|.:|.|    ::.|...|
  Fly   808 GFNPPDLDIMEKPPRKA-DEGLISGWL-FFRYMAIGFYVGAATVGAAAWWFVF----SDEGPKLS 866

  Fly   868 RLKGIREDWD-SKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSIVVT-QVFDLLICKTRRNSI 930
            .       |. :.::..|  |.|.|:...:.|:..........:|::|| ::.:.:...:...|:
  Fly   867 Y-------WQLTHHLSCL--GGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSENQSL 922

  Fly   931 LQQG-------MGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWIYAFPFGLLIFFFD 988
            :...       :|:..|:|  .|.|:|    .||.|.....::..:....||....|.:.:...|
  Fly   923 ITMPPWCNLWLIGSMALSF--TLHFVI----LYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLD 981

  Fly   989 ESRRFLIRRNPGG 1001
            |:.:|:.|:...|
  Fly   982 ETLKFVARKIADG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	312/1053 (30%)
		Cation_ATPase_N	29..102	CDD:214842	21/72 (29%)
		E1-E2_ATPase	123..354	CDD:278548	75/247 (30%)
		Cation_ATPase	416..509	CDD:289987	27/119 (23%)
		COG4087	<673..738	CDD:226572	37/64 (58%)
		Cation_ATPase_C	785..994	CDD:279079	49/223 (22%)
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	309/1044 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438598
Domainoid	1	1.000	48	1.000	Domainoid score	I3472
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I96
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51342
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890