DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and Atp4a

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_036641.1	Gene:	Atp4a / 24216	RGDID:	2177	Length:	1034	Species:	Rattus norvegicus

Alignment Length:	1016	Identity:	545/1016 - (53%)
Similarity:	716/1016 - (70%)	Gaps:	10/1016 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPKKKNKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEI-- 63
            |..|...|:....|.:||:.:::.||::|.::|::.|.||.::.:|....||   :|.|..|:
  Rat    22 MAAKMSKKKAGGGGGKKKEKLENMKKEMEMNDHQLSVSELEQKYQTSATKGL---KASLAAELLL 83

  Fly    64 -NGPNILTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTV 127
             :|||.|.|...||:::.|.:.:.||...|:|..:.:|.:.:.||........||||||.:||..
  Rat    84 RDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIA 148

  Fly   128 LVIVTGLFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADI 192
            :|:|||.|.|:|..||::|:.||||||||.|||||:|:...:.:|::|.||:||:|.||||||||
  Rat   149 VVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADI 213

  Fly   193 RILEAHGLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMG 257
            |||.|.|.||||||||||||||.||.|.|||:||||:|:|||||..||||.:|:|::|||.|::|
  Rat   214 RILSAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVSTGDRTIIG 278

  Fly   258 RIANLAAGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVP 322
            |||:||:|:::.::||:.||:.|:..|...||:.|.:||.:::.:||.|:.|:||.:.|:||.||
  Rat   279 RIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFVVAMCIGYTFLRAMVFFMAIVVAYVP 343

  Fly   323 EGLLVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIV 387
            ||||.||||||:|||||:|||||:||||||||||||||.||||||||||||||||:|||:|..|.
  Rat   344 EGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIH 408

  Fly   388 ESDTTESFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETI 452
            .:||||...|..|....:::.||.....|||.|.||.|||.:||.|:.|.|:|||.|||||:|..
  Rat   409 TADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELT 473

  Fly   453 FAGIGAFRQKHIKLTEIPFNSTEKYQVSVHEF-NSSDGYFIVEMKGAPERILDRCSTIIIQGLSV 516
            ......:|.:..|:.|||||||.|:|:|:|.. :..|...::.|||||||:|:|||:|:|:|..:
  Rat   474 LGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQEL 538

  Fly   517 ELTPTLKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLID 581
            .|....:..|:.|||.:||:|||||||..|.|....||..|.|..:..|||...|.|.||:|:||
  Rat   539 PLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYTFDVEAMNFPSSGLCFAGLVSMID 603

  Fly   582 PPRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSR 644
            ||||.|||||.|||:||:|||||||||||||||||.|||||:  :.|.||||.:..:.|..::.:
  Rat   604 PPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRMPVDQVNKK 668

  Fly   645 QATAIVVHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSP 709
            .|.|.|::|.:|::|...||...:..|.|:|||||||||||:|||:|||.|.|||||||||||||
  Rat   669 DARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSP 733

  Fly   710 ALKRADIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIV 774
            |||:|||||||||:|||.:|.|||||||||||||||.|:|:||:||||||||||||||.|:||:.
  Rat   734 ALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELT 798

  Fly   775 PFLFFVIFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMA 839
            |:|.::...:||.||.|.||.|::.||:.|::||||||||||||...||:|..|||||:.|...:
  Rat   799 PYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPRRDRLVNEPLAAYS 863

  Fly   840 YLQIGVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTA 904
            |.|||.||:.|.|..:|..||:.|:.|....|:|..|:..:::||:|.||||||:.:|...:||.
  Rat   864 YFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWEDHHLQDLQDSYGQEWTFGQRLYQQYTC 928

  Fly   905 GTGFFVSIVVTQVFDLLICKTRRNSILQQG-MGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYS 968
            .|.||:||.:.|:.|:||.||||.|..||| ..|.:|..|:|.:..|.|.|||.|..........
  Rat   929 YTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMP 993

  Fly   969 IKFIWWIYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            |:|.||:...|||||||.:||.|:..:|..||.|.:||.||
  Rat   994 IRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQELYY 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	539/998 (54%)
		Cation_ATPase_N	29..102	CDD:214842	24/75 (32%)
		E1-E2_ATPase	123..354	CDD:278548	141/230 (61%)
		Cation_ATPase	416..509	CDD:289987	48/93 (52%)
		COG4087	<673..738	CDD:226572	54/64 (84%)
		Cation_ATPase_C	785..994	CDD:279079	101/209 (48%)
Atp4a	NP_036641.1	H-K_ATPase_N	2..>27	CDD:286172	2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..40		5/17 (29%)
		ATPase-IIC_X-K	42..1034	CDD:273445	537/994 (54%)
		Cation_ATPase_N	50..124	CDD:214842	24/76 (32%)
		E1-E2_ATPase	145..375	CDD:278548	141/229 (62%)
		Cation_ATPase	437..531	CDD:289987	48/93 (52%)
		COG4087	<687..>742	CDD:226572	41/54 (76%)
		Cation_ATPase_C	809..1018	CDD:279079	101/208 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930