DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34297 and TTC4

DIOPT Version :9

Sequence 1:	NP_001097696.1	Gene:	CG34297 / 5740802	FlyBaseID:	FBgn0085326	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_004614.3	Gene:	TTC4 / 7268	HGNCID:	12394	Length:	387	Species:	Homo sapiens

Alignment Length:	167	Identity:	36/167 - (21%)
Similarity:	74/167 - (44%)	Gaps:	23/167 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 DRSKDRFP-FMRQVEMDLDQRSKARL----------ER--ERVAQNFRKLGNAEYRKGNYEAAMK 140
            ::..::.| ||.:...::|.|....|          ||  |..|:.::..||..:::.:|:.|:.
Human    36 EKEFEKVPLFMSRAPSEIDPRENPDLACLQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVI 100

  Fly   141 VYTEAI-ENIRD---SHILYINRALCFIKSGKFKRGIVDCDFVLNKLDEKNLRAWMYRAMAYKGL 201
            .|||.: :...|   :.:||.|||......|.|:..:.|.. ...||...:|:|.:..|:.:..|
Human   101 SYTEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSALNDVT-AARKLKPCHLKAIIRGALCHLEL 164

  Fly   202 NDESNFENCVKYARKFNSKQMDFID-----DFLEKLK 233
            ...:...|......:.::|:...::     |.|::::
Human   165 KHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIE 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34297	NP_001097696.1	TPR_11	119..185	CDD:290150	19/69 (28%)
		TPR repeat	119..147	CDD:276809	8/28 (29%)
		TPR repeat	152..183	CDD:276809	8/30 (27%)
		TPR repeat	188..216	CDD:276809	5/27 (19%)
TTC4	NP_004614.3	TPR_11	78..148	CDD:290150	19/70 (27%)
		TPR 1	79..112		8/32 (25%)
		TPR repeat	79..107	CDD:276809	8/27 (30%)
		TPR repeat	116..146	CDD:276809	8/30 (27%)
		TPR 2	117..150		10/33 (30%)
		TPR_16	123..181	CDD:290168	12/58 (21%)
		TPR 3	151..184		5/32 (16%)
		TPR repeat	151..179	CDD:276809	5/27 (19%)
		NinG	173..>236	CDD:283434	3/29 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R218
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940