DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34448 and Lpl

DIOPT Version :9

Sequence 1:	NP_001097059.1	Gene:	CG34448 / 5740554	FlyBaseID:	FBgn0085477	Length:	344	Species:	Drosophila melanogaster
Sequence 2:	NP_036730.1	Gene:	Lpl / 24539	RGDID:	3017	Length:	474	Species:	Rattus norvegicus

Alignment Length:	273	Identity:	80/273 - (29%)
Similarity:	121/273 - (44%)	Gaps:	41/273 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ILIHGFIGN---RNLTPNLEVRDVLLQTQP-INVISVDYGTLVRWPCYYPWAVNNAPIVSECLAQ 138
            ::|||:...   .:..|.|..  .|.:.:| .|||.||:  |.|...:||.:.....:|...:|:
  Rat    77 VVIHGWTVTGMYESWVPKLVA--ALYKREPDSNVIVVDW--LYRAQQHYPVSAGYTKLVGNDVAR 137

  Fly   139 MINNLISAGISRREDIHLIGFSLGAQVAGMVANYVSQPLARITGLDPAGPGF--MMQPSLQQKLD 201
            .||.|........:::||:|:||||..||:..:..::.:.||||||||||.|  ...||   :|.
  Rat   138 FINWLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPS---RLS 199

  Fly   202 ASDADFVDIIHTDPFFFSMLP--------PMGHADFYPNLDQLNQRGCSYISNWR---------- 248
            ..||||||::||   |....|        |:||.|.|||.... |.||:.....|
  Rat   200 PDDADFVDVLHT---FTRGSPGRSIGIQKPVGHVDIYPNGGTF-QPGCNIGEAIRVIAEKGLGDV 260

  Fly   249 --FYNCNHYRAAVYYGESIISERG-FWAQQCGGWFDFFSQRCSHYSNMPNTQMGYFVSE---DAS 307
              ...|:|.|:...:.:|:::|.. ..|.:|.....|....|..........:||.:::   ..|
  Rat   261 DQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRAKRS 325

  Fly   308 GSYFLTTHEVAPF 320
            ...:|.|....|:
  Rat   326 SKMYLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34448	NP_001097059.1	Pancreat_lipase_like	44..316	CDD:238363	79/267 (30%)
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53
		lipo_lipase	33..472	CDD:132274	80/273 (29%)
		Pancreat_lipase_like	37..334	CDD:238363	79/267 (30%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		2/22 (9%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100