Protein Alignment Fili and Lrrc15

DIOPT Version :8

• Sequence 1: NP_001097402.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_083249.1
• Gene: Lrrc15 / 74488
• MGIID: 1921738
• Length: 579
• Species: Mus musculus
• Alignment Length: 585
• Identity: 137/586 (23%)
• Similarity: 226/586 (39%)
• Gaps: 138/586 (24%)

  Fly    42 CPSKCQCLGGEANSRALCVDAALEDVPIQLN----------------PETKYINLTV-------- 82
            |||:|.|   ...|:..|..|.:..:|..|.                ||.|::|::.
Mouse    25 CPSECTC---SRASQVECTGAQIVAMPSPLPWNAMSLQILNTHITELPEDKFLNISALIALKMEK 86

  Fly    83 NRIRTLEFSLPFYMK----LEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGL 143
            |.:..:   :|...:    |..|.|:.|.::.|..:.|:..:.|.||.||.|.:..:....|...
Mouse    87 NELANI---MPGAFRNLGSLRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQPAQFSQF 148

  Fly   144 TNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVP 208
            :||..|.|..|.:|.:.......|..|.:|:|.||....|....|:.:..|:||....|||.|:|
Mouse   149 SNLKELQLYGNNLEYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRLYENRLSDIP 213

  Fly   209 -----------------------ASNLWHLHA-LKSLDMSLNLVEFVRNDSFEGLKELLALSVQG 249
                                   :..|:|.:. |:.|.:|.|.:..:....|..|..|..|::.|
Mouse   214 MGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLPHLNKLTLFG 278

  Fly   250 NVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHL 314
            |.:.||....|..:.:|:.|.|.:|::|.:|....|.|:.|..|.|..|:.|.:...||..|.:|
Mouse   279 NSLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISPGAFNGLTNL 343

  Fly   315 RELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYS 379
            |||.| ..:.||.:|...|....:|:.:.|.|| :|..:|..:|.....::.:.:|:|:|:.|..
Mouse   344 RELSL-HTNALQDLDGNVFRSLANLRNVSLQNN-RLRQLPGSIFANVNGLMTIQLQNNNLENLPL 406

  Fly   380 AQFP-VDQLQKLYLGDNPLQCNCSLL----WL----WRLVTG---------------------NF 414
            ..|. :..|.:|.|.|||.:|:.::|    ||    .||.|.                     ||
Mouse   407 GIFDHLGNLCELRLYDNPWRCDSNILPLHDWLILNRARLGTDTLPVCSSPASVRGQSLVIINVNF 471

  Fly   415 EGVD-PGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSA 478
            .|.. .|.|.....:....:...|...::.......||||.             ...|:|.||
Mouse   472 PGPSVQGPETPEVSSYPDTSSYPDSTSISSTTEITRSTDDD-------------YTDLNTIEP-- 521

  Fly   479 YELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPAHIVTVV---CAVITCL 540
                  ..:||:              |.         :|.::..:...|.::.::   |::..|:
Mouse   522 ------IDDRNT--------------WG---------MTDAQSGLAIAAIVIGIIALACSLAACI 557

  Fly   541  540
            Mouse   558  557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001097402.1	leucine-rich repeat	75..97	CDD:275378	4/30 (13%)
		LRR_RI	79..327	CDD:238064	76/284 (27%)
		leucine-rich repeat	98..121	CDD:275380	6/23 (26%)
		LRR_8	120..180	CDD:290566	19/60 (32%)
		leucine-rich repeat	122..145	CDD:275380	7/23 (30%)
		leucine-rich repeat	146..169	CDD:275380	6/23 (26%)
		LRR_8	169..228	CDD:290566	21/83 (25%)
		leucine-rich repeat	170..193	CDD:275380	7/23 (30%)
		leucine-rich repeat	194..217	CDD:275380	10/46 (22%)
		LRR_8	218..276	CDD:290566	17/58 (29%)
		leucine-rich repeat	218..265	CDD:275380	13/47 (28%)
		LRR_RI	<265..406	CDD:238064	46/146 (32%)
		LRR_8	265..321	CDD:290566	21/56 (38%)
		leucine-rich repeat	266..289	CDD:275380	8/23 (35%)
		leucine-rich repeat	290..313	CDD:275380	8/23 (35%)
		leucine-rich repeat	314..338	CDD:275380	9/24 (38%)
		LRR_8	337..397	CDD:290566	18/61 (30%)
		leucine-rich repeat	339..360	CDD:275380	7/21 (33%)
Lrrc15	NP_083249.1	LRR 1	54..75		3/21 (14%)
		leucine-rich repeat	58..78	CDD:275380	4/20 (20%)
		LRR 2	78..99		2/24 (8%)
		LRR_8	82..137	CDD:290566	14/58 (24%)
		LRR 3	102..123		6/21 (29%)
		leucine-rich repeat	103..126	CDD:275380	6/23 (26%)
		LRR_8	126..185	CDD:290566	19/59 (32%)
		LRR 4	126..147		7/21 (33%)
		leucine-rich repeat	127..150	CDD:275380	7/23 (30%)
		LRR 5	150..171		6/21 (29%)
		LRR_RI	151..331	CDD:238064	49/180 (27%)
		leucine-rich repeat	151..174	CDD:275380	6/23 (26%)
		LRR 6	174..195		7/21 (33%)
		leucine-rich repeat	175..198	CDD:275380	7/23 (30%)
		LRR_8	198..257	CDD:290566	14/59 (24%)
		LRR 7	198..219		8/21 (38%)
		leucine-rich repeat	199..222	CDD:275380	8/23 (35%)
		LRR 8	222..243		2/21 (10%)
		leucine-rich repeat	223..246	CDD:275380	2/23 (9%)
		LRR_8	245..305	CDD:290566	17/60 (28%)
		LRR 9	246..267		5/21 (24%)
		leucine-rich repeat	247..270	CDD:275380	6/23 (26%)
		LRR 10	270..291		7/21 (33%)
		leucine-rich repeat	271..294	CDD:275380	7/23 (30%)
		LRR_8	293..353	CDD:290566	21/61 (34%)
		LRR 11	294..315		7/21 (33%)
		leucine-rich repeat	295..318	CDD:275380	8/23 (35%)
		LRR_4	318..358	CDD:289563	16/41 (39%)
		LRR 12	318..339		7/21 (33%)
		leucine-rich repeat	319..342	CDD:275380	8/23 (35%)
		LRR 13	342..363		9/22 (41%)
		leucine-rich repeat	343..364	CDD:275380	9/22 (41%)
		LRR_8	366..424	CDD:290566	17/59 (29%)
		LRR 14	366..387		7/22 (32%)
		leucine-rich repeat	367..387	CDD:275380	7/21 (33%)
		LRR 15	390..411		5/21 (24%)
		leucine-rich repeat	391..412	CDD:275380	5/21 (24%)
		LRRCT	423..>462	CDD:214507	9/39 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100