DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and Lingo1

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_001094192.1	Gene:	Lingo1 / 315691	RGDID:	1308668	Length:	620	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	125/409 - (30%)
Similarity:	184/409 - (44%)	Gaps:	50/409 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRA-LCVDAALEDVPIQLNPETKYINLTVNRI 85
            |:|||:|.:  :|....|. ||.:|:|   .|..|| ||.......||..:..||:.::|..|||
  Rat    25 PILLLVLGS--VLSGSATG-CPPRCEC---SAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRI 83

  Fly    86 RTL---EF-SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNL 146
            :||   || |.|   .||.|:|::||:..:....|.....||||.|..|.:..:....|.||:||
  Rat    84 KTLNQDEFASFP---HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNL 145

  Fly   147 LLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASN 211
            ..||:|.|:|..:......||.:|..|::.:|::|.:....|.|:|:||.|......|..:|...
  Rat   146 TKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEA 210

  Fly   212 LWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSV-QGNVMSELDLSAFEGLISLKHLDLSDNN 275
            |.|||.|..|.:....:..:|:.||:.|..|..|.: ....:..:..:...|| :|..|.::..|
  Rat   211 LSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCN 274

  Fly   276 LTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQ 340
            ||.||...:..|..|.:|||..|....:.......|..|:|:.|.
  Rat   275 LTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLV-------------------- 319

  Fly   341 TLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCSLL 404
                  ..||:.:....|:|...:..:.:..|.|.||..:.| .|..|:.|.|..|||.|:|.||
  Rat   320 ------GGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLL 378

  Fly   405 WL----WRLVTGNFEGVDP 419
            |:    |||   ||....|
  Rat   379 WVFRRRWRL---NFNRQQP 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	11/25 (44%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	47/193 (24%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	10/47 (21%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	14/60 (23%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	13/37 (35%)
		LRR	<66..371	CDD:227223	95/334 (28%)
		leucine-rich repeat	73..96	CDD:275380	11/25 (44%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		LRR_8	120..179	CDD:404697	21/58 (36%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		leucine-rich repeat	145..192	CDD:275380	14/46 (30%)
		leucine-rich repeat	193..216	CDD:275380	8/22 (36%)
		leucine-rich repeat	217..264	CDD:275380	10/47 (21%)
		leucine-rich repeat	265..288	CDD:275380	8/22 (36%)
		leucine-rich repeat	289..312	CDD:275380	6/22 (27%)
		leucine-rich repeat	313..336	CDD:275380	7/48 (15%)
		leucine-rich repeat	337..357	CDD:275380	5/19 (26%)
		PCC	341..>421	CDD:188093	23/57 (40%)
		IgI_Lingo-1	423..514	CDD:409561
		Ig strand B	442..446	CDD:409561
		Ig strand C	455..459	CDD:409561
		Ig strand E	480..484	CDD:409561
		Ig strand F	494..499	CDD:409561
		Ig strand G	507..510	CDD:409561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BH3X
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8997
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1280
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910