Protein Alignment Fili and Lingo1

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001094192.1
• Gene: Lingo1 / 315691
• RGDID: 1308668
• Length: 620
• Species: Rattus norvegicus
• Alignment Length: 409
• Identity: 125/409 - (30%)
• Similarity: 184/409 - (44%)
• Gaps: 50/409 - (12%)

  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRA-LCVDAALEDVPIQLNPETKYINLTVNRI 85
            |:|||:|.:  :|....|. ||.:|:|   .|..|| ||.......||..:..||:.::|..|||
  Rat    25 PILLLVLGS--VLSGSATG-CPPRCEC---SAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRI 83

  Fly    86 RTL---EF-SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNL 146
            :||   || |.|   .||.|:|::||:..:....|.....||||.|..|.:..:....|.||:||
  Rat    84 KTLNQDEFASFP---HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNL 145

  Fly   147 LLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASN 211
            ..||:|.|:|..:......||.:|..|::.:|::|.:....|.|:|:||.|......|..:|...
  Rat   146 TKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEA 210

  Fly   212 LWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSV-QGNVMSELDLSAFEGLISLKHLDLSDNN 275
            |.|||.|..|.:....:..:|:.||:.|..|..|.: ....:..:..:...|| :|..|.::..|
  Rat   211 LSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCN 274

  Fly   276 LTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQ 340
            ||.||...:..|..|.:|||..|....:.......|..|:|:.|.
  Rat   275 LTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLV-------------------- 319

  Fly   341 TLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCSLL 404
                  ..||:.:....|:|...:..:.:..|.|.||..:.| .|..|:.|.|..|||.|:|.||
  Rat   320 ------GGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLL 378

  Fly   405 WL----WRLVTGNFEGVDP 419
            |:    |||   ||....|
  Rat   379 WVFRRRWRL---NFNRQQP 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	80/281 (28%)
		leucine-rich repeat	75..97	CDD:275378	11/25 (44%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	10/47 (21%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	14/60 (23%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)
Lingo1	NP_001094192.1	LRRNT	41..75	CDD:214470	13/37 (35%)
		LRR	71..>371	CDD:443914	94/329 (29%)
		leucine-rich repeat	73..96	CDD:275380	11/25 (44%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	9/22 (41%)
		leucine-rich repeat	145..192	CDD:275380	14/46 (30%)
		leucine-rich repeat	193..216	CDD:275380	8/22 (36%)
		leucine-rich repeat	217..264	CDD:275380	10/47 (21%)
		leucine-rich repeat	265..288	CDD:275380	8/22 (36%)
		leucine-rich repeat	289..312	CDD:275380	6/22 (27%)
		leucine-rich repeat	313..336	CDD:275380	7/48 (15%)
		leucine-rich repeat	337..357	CDD:275380	5/19 (26%)
		PCC	341..>421	CDD:188093	23/57 (40%)
		IgI_Lingo-1	423..514	CDD:409561
		Ig strand A	423..426	CDD:409561
		Ig strand A'	431..435	CDD:409561
		Ig strand B	441..450	CDD:409561
		Ig strand C	455..460	CDD:409561
		Ig strand C'	463..465	CDD:409561
		Ig strand D	474..477	CDD:409561
		Ig strand E	480..487	CDD:409561
		Ig strand F	493..501	CDD:409561
		Ig strand G	504..514	CDD:409561