Protein Alignment Fili and FLRT3

DIOPT Version :8

• Sequence 1: NP_001097402.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_037413.1
• Gene: FLRT3 / 23767
• HGNCID: 3762
• Length: 649
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 125/533 (23%)
• Similarity: 199/533 (37%)
• Gaps: 122/533 (23%)

  Fly    29 LTLVILPPETTA-FCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT--LEF 90
            |.|.:.|....| .|||.|:|..|    ...|.|..|..:|..:..:...:.|..|:|..  :..
Human    17 LFLQVAPLSVMAKSCPSVCRCDAG----FIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPS 77

  Fly    91 SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNR 155
            .|...:|:|.:.|..|.::       |:.:.|      ...|..||              |..|.
Human    78 DLKNLLKVERIYLYHNSLD-------EFPTNL------PKYVKELH--------------LQENN 115

  Fly   156 IETVHPTALSDLASLVELDLTNNNI--VSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHL-HA 217
            |.|:...:||.:..|.||.|.:|::  ||:|:..|:..|.|.:|....|.|..:|    |.| ..
Human   116 IRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP----WGLPRT 176

  Fly   218 LKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDL--SAFEGLISLKHLDLSDNNLTMVP 280
            ::.|.:..|.:..:.:.|.:||..|..|.:.||:::...|  ..|..|::|..|.|..|:||..|
Human   177 IEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241

  Fly   281 TQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLN 345
            .....  :||..|.|..|..:::|..||   .:||:|:  |||.                   .|
Human   242 VNLPG--TNLRKLYLQDNHINRVPPNAF---SYLRQLY--RLDM-------------------SN 280

  Fly   346 NNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWL--WR 408
            ||  ||::|..:|.                       .:|.:.:|.|.:||..|.|.:.|:  |.
Human   281 NN--LSNLPQGIFD-----------------------DLDNITQLILRNNPWYCGCKMKWVRDWL 320

  Fly   409 L---VTGNFEG-VDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVN 469
            .   |..|..| :....|...|.|:..|..|..|           ..|.|:.:.......  |.|
Human   321 QSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFD-----------CKDSGIVSTIQITTA--IPN 372

  Fly   470 ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPA-HIVTVV 533
            .::..:.......|...:..:..|..|.|..|        ...||.:|::...:|... ||...:
Human   373 TVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTG--------SPSRKTITITVKSVTSDTIHISWKL 429

  Fly   534 CAVITCLLVAMI 545
            ...:|.|.::.:
Human   430 ALPMTALRLSWL 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001097402.1	leucine-rich repeat	75..97	CDD:275378	4/24 (17%)
		LRR_RI	79..327	CDD:238064	69/255 (27%)
		leucine-rich repeat	98..121	CDD:275380	4/23 (17%)
		LRR_8	120..180	CDD:290566	15/60 (25%)
		leucine-rich repeat	122..145	CDD:275380	4/23 (17%)
		leucine-rich repeat	146..169	CDD:275380	6/23 (26%)
		LRR_8	169..228	CDD:290566	19/62 (31%)
		leucine-rich repeat	170..193	CDD:275380	10/25 (40%)
		leucine-rich repeat	194..217	CDD:275380	7/24 (29%)
		LRR_8	218..276	CDD:290566	16/60 (27%)
		leucine-rich repeat	218..265	CDD:275380	12/49 (24%)
		LRR_RI	<265..406	CDD:238064	36/141 (26%)
		LRR_8	265..321	CDD:290566	18/56 (32%)
		leucine-rich repeat	266..289	CDD:275380	7/23 (30%)
		leucine-rich repeat	290..313	CDD:275380	7/23 (30%)
		leucine-rich repeat	314..338	CDD:275380	6/24 (25%)
		LRR_8	337..397	CDD:290566	12/60 (20%)
		leucine-rich repeat	339..360	CDD:275380	7/21 (33%)
FLRT3	NP_037413.1	LRRNT	31..61	CDD:214470	10/34 (29%)
		Interaction with ADGRL3. {ECO:0000269|PubMed:26235030}	38..67		6/33 (18%)
		LRR 1. {ECO:0000255}	59..80		4/21 (19%)
		leucine-rich repeat	61..84	CDD:275378	4/23 (17%)
		LRR 2. {ECO:0000255}	84..104		6/33 (18%)
		leucine-rich repeat	85..104	CDD:275380	5/32 (16%)
		LRR 3. {ECO:0000255}	105..126		9/35 (26%)
		LRR_8	106..166	CDD:290566	22/74 (30%)
		leucine-rich repeat	106..129	CDD:275380	9/37 (24%)
		LRR_RI	<120..259	CDD:238064	43/145 (30%)
		LRR 4. {ECO:0000255}	129..150		8/21 (38%)
		leucine-rich repeat	130..155	CDD:275380	10/25 (40%)
		LRR 5. {ECO:0000255}	155..175		7/24 (29%)
		leucine-rich repeat	156..176	CDD:275380	7/24 (29%)
		LRR_8	175..237	CDD:290566	16/62 (26%)
		LRR 6. {ECO:0000255}	176..197		3/21 (14%)
		leucine-rich repeat	177..200	CDD:275380	5/23 (22%)
		LRR 7. {ECO:0000255}	200..220		5/20 (25%)
		leucine-rich repeat	201..226	CDD:275380	7/25 (28%)
		LRR 8. {ECO:0000255}	226..247		7/23 (30%)
		leucine-rich repeat	227..248	CDD:275380	7/23 (30%)
		LRR_8	247..306	CDD:290566	25/108 (23%)
		LRR_4	247..287	CDD:289563	19/66 (29%)
		LRR 9. {ECO:0000255}	248..269		8/24 (33%)
		leucine-rich repeat	249..272	CDD:275380	9/26 (35%)
		LRR 10. {ECO:0000255}	272..293		11/67 (16%)
		leucine-rich repeat	273..296	CDD:275380	12/69 (17%)
		LRRCT	305..356	CDD:214507	15/62 (24%)
		fn3	413..478	CDD:278470	5/30 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	1	0.960