DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fili and FLRT3

DIOPT Version :9

Sequence 1:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster
Sequence 2:	NP_037413.1	Gene:	FLRT3 / 23767	HGNCID:	3762	Length:	649	Species:	Homo sapiens

Alignment Length:	532	Identity:	125/532 - (23%)
Similarity:	199/532 - (37%)	Gaps:	122/532 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LTLVILPPETTA-FCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT--LEF 90
            |.|.:.|....| .|||.|:|..|    ...|.|..|..:|..:..:...:.|..|:|..  :..
Human    17 LFLQVAPLSVMAKSCPSVCRCDAG----FIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPS 77

  Fly    91 SLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNR 155
            .|...:|:|.:.|..|.::       |:.:.|      ...|..||              |..|.
Human    78 DLKNLLKVERIYLYHNSLD-------EFPTNL------PKYVKELH--------------LQENN 115

  Fly   156 IETVHPTALSDLASLVELDLTNNNI--VSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHL-HA 217
            |.|:...:||.:..|.||.|.:|::  ||:|:..|:..|.|.:|....|.|..:|    |.| ..
Human   116 IRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP----WGLPRT 176

  Fly   218 LKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDL--SAFEGLISLKHLDLSDNNLTMVP 280
            ::.|.:..|.:..:.:.|.:||..|..|.:.||:::...|  ..|..|::|..|.|..|:||..|
Human   177 IEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241

  Fly   281 TQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLN 345
            .....  :||..|.|..|..:::|..||   .:||:|:  |||.                   .|
Human   242 VNLPG--TNLRKLYLQDNHINRVPPNAF---SYLRQLY--RLDM-------------------SN 280

  Fly   346 NNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCSLLWL--WR 408
            ||  ||::|..:|.                       .:|.:.:|.|.:||..|.|.:.|:  |.
Human   281 NN--LSNLPQGIFD-----------------------DLDNITQLILRNNPWYCGCKMKWVRDWL 320

  Fly   409 L---VTGNFEG-VDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAYIAEQHIVN 469
            .   |..|..| :....|...|.|:..|..|..|           ..|.|:.:.......  |.|
Human   321 QSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFD-----------CKDSGIVSTIQITTA--IPN 372

  Fly   470 ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPA-HIVTVV 533
            .::..:.......|...:..:..|..|.|..|        ...||.:|::...:|... ||...:
Human   373 TVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTG--------SPSRKTITITVKSVTSDTIHISWKL 429

  Fly   534 CAVITCLLVAMI 545
            ...:|.|.::.:
Human   430 ALPMTALRLSWL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/23 (17%)
		leucine-rich repeat	98..121	CDD:275380	4/22 (18%)
		LRR_8	120..180	CDD:404697	15/59 (25%)
		leucine-rich repeat	122..145	CDD:275380	4/22 (18%)
		leucine-rich repeat	146..169	CDD:275380	6/22 (27%)
		LRR	<161..>354	CDD:227223	57/197 (29%)
		leucine-rich repeat	170..193	CDD:275380	9/24 (38%)
		leucine-rich repeat	194..217	CDD:275380	7/23 (30%)
		leucine-rich repeat	218..265	CDD:275380	12/48 (25%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	7/22 (32%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	11/59 (19%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)
FLRT3	NP_037413.1	LRRNT	31..61	CDD:214470	10/33 (30%)
		Interaction with ADGRL3. /evidence=ECO:0000269\|PubMed:26235030	38..67		6/32 (19%)
		LRR 1. /evidence=ECO:0000255	59..80		3/20 (15%)
		leucine-rich repeat	61..84	CDD:275378	4/22 (18%)
		LRR 2. /evidence=ECO:0000255	84..104		6/32 (19%)
		leucine-rich repeat	85..104	CDD:275380	5/31 (16%)
		LRR 3. /evidence=ECO:0000255	105..126		8/34 (24%)
		LRR_8	106..166	CDD:290566	22/73 (30%)
		leucine-rich repeat	106..129	CDD:275380	9/36 (25%)
		LRR_RI	<120..259	CDD:238064	43/144 (30%)
		LRR 4. /evidence=ECO:0000255	129..150		8/20 (40%)
		leucine-rich repeat	130..155	CDD:275380	9/24 (38%)
		LRR 5. /evidence=ECO:0000255	155..175		7/23 (30%)
		leucine-rich repeat	156..176	CDD:275380	7/23 (30%)
		LRR_8	175..237	CDD:290566	16/61 (26%)
		LRR 6. /evidence=ECO:0000255	176..197		3/20 (15%)
		leucine-rich repeat	177..200	CDD:275380	5/22 (23%)
		LRR 7. /evidence=ECO:0000255	200..220		5/19 (26%)
		leucine-rich repeat	201..226	CDD:275380	7/24 (29%)
		LRR 8. /evidence=ECO:0000255	226..247		7/22 (32%)
		leucine-rich repeat	227..248	CDD:275380	7/22 (32%)
		LRR_8	247..306	CDD:290566	24/107 (22%)
		LRR_4	247..287	CDD:289563	19/65 (29%)
		LRR 9. /evidence=ECO:0000255	248..269		8/23 (35%)
		leucine-rich repeat	249..272	CDD:275380	8/25 (32%)
		LRR 10. /evidence=ECO:0000255	272..293		11/66 (17%)
		leucine-rich repeat	273..296	CDD:275380	11/68 (16%)
		LRRCT	305..356	CDD:214507	15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		4/27 (15%)
		fn3	413..478	CDD:278470	5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870