Protein Alignment Fili and chadlb

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001274009.2
• Gene: chadlb / 100330176
• ZFINID: ZDB-GENE-121205-5
• Length: 765
• Species: Danio rerio
• Alignment Length: 748
• Identity: 165/748 - (22%)
• Similarity: 288/748 - (38%)
• Gaps: 209/748 - (27%)

  Fly    19 GAIPVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVN 83
            |:||...:::|..:.:....:|.||..|.|  ........||:..|.:||..::      .:||.
Zfish     2 GSIPTWPVIILFALKIHTALSAKCPKVCVC--DSIQLTIACVNKNLTEVPPTID------EITVK 58

  Fly    84 RIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLL 148
                             |||..|.::.|.:..|.:...|..|:|..:.:..:.:.||:.|..|:|
Zfish    59 -----------------LDLRGNDLQELPTGAFAHTPYLTHLSLQNSNIRRVREGAFRKLGRLVL 106

  Fly   149 LDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLW 213
            |:|:.|:||.::..:...|:||.:|.:..|.:..::...|..:..|.:|...:|:|:.:|
Zfish   107 LNLANNKIEILYQESFDGLSSLKQLIIDRNRVEEIQPGAFSQLGFLNLLSLTHNQLVYIP----- 166

  Fly   214 HLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTM 278
                               |.:|:||:.:..|.:..|.::.|...||.||.:|..|.|.:|.|..
Zfish   167 -------------------NMAFQGLQNIKWLRLSHNFINYLATEAFAGLFTLTRLSLDNNELQF 212

  Fly   279 VPTQQLSKLSNLTYLNLGGNRFSQL--PAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQT 341
            .||:.:::||.:|.|.|..|..:.|  .:|:.|.|.||...|.|..||    .:.|.:.:..|..
Zfish   213 FPTETMTRLSEVTRLELSFNPMTYLGEESVSMLKLTHLLLDHNSLQDF----SNAAILLSPRLTH 273

  Fly   342 LHLNNNPQLSDIPMRLFQ----GNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLGDNPLQCNCS 402
            |.|::|      .:|:.|    |:|                       :|.:|.|..||:.|:|.
Zfish   274 LDLSHN------QLRILQPMAPGSP-----------------------KLTRLNLAGNPIYCSCY 309

  Fly   403 L--LWLW----RLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELADEATAVASTDDGVAALAAY 461
            |  |..|    |:..|   |...|..|.:|          ::.|:.........:.:  |.|.|.
Zfish   310 LRPLREWATRERVRLG---GTCGGPAHLSG----------ENLEVVQPVNLRCLSQE--AMLKAE 359

  Fly   462 IAEQHIVNALHTTEPSAYE------LATSSSNR-----NSGILRMDR------------------ 497
            :.|| ::.||.|| ||..:      .|..:.||     |.|..::.|
Zfish   360 LEEQ-VLPALPTT-PSPKKGKCPANCACETENRHSSCENKGHTKIPRGFSPDTRLLDLRGNHFHY 422

  Fly   498 ----------QQIGCDIWRDKVRT--------RRKL--LTMSEGEITCPAHIVTVVCAVITCLLV 542
                      :.:...:.|.|:..        .:.|  |.:||.::|             :....
Zfish   423 IPANSFPGTAEVVSLHLQRCKIHDIEDGAFSGMKSLVYLYLSENDLT-------------SLTPE 474

  Fly   543 AMIGISVLYYLRFVKRRRKLLHERGPMRTSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNG 607
            |..|:..|.||. :::.|.....:|..:....::.:|   ::.:....|..|:   |.....:.|
Zfish   475 AFKGLPHLTYLH-LEKNRFTQFPKGAFKLLPGLLALH---MENNAIAKLETGL---LTSAEKLRG 532

  Fly   608 LGMTLNYPHHAQTLQAHHHYHQAMPLQS-HGGNGNHEYQQTTLPQLDKLELERYLAAQTIANEYR 671
            |.:|.|    |.|..|...::.|..|:: |.|:.          :|.::..|.:..|:::|.
Zfish   533 LYLTSN----AITAAAPQAFNPAPDLETLHLGSN----------KLQEVPTEAFSKARSLAE--- 580

  Fly   672 ALKPWELPVK---EADDEP-----EHLYERFDH 696
             ||....|::   ....:|     .|||  .||
Zfish   581 -LKLSHNPIRWIGAGAFQPVGTTLRHLY--LDH 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	70/278 (25%)
		leucine-rich repeat	75..97	CDD:275378	2/21 (10%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		leucine-rich repeat	122..145	CDD:275380	6/22 (27%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		leucine-rich repeat	170..193	CDD:275380	4/22 (18%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	11/46 (24%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	8/24 (33%)
		leucine-rich repeat	314..338	CDD:275380	6/23 (26%)
		LRR_8	337..397	CDD:404697	12/63 (19%)
		leucine-rich repeat	339..360	CDD:275380	6/24 (25%)
chadlb	NP_001274009.2	None