Protein Alignment Fili and lingo4a

DIOPT Version :10

• Sequence 1: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Sequence 2: NP_001076447.1
• Gene: lingo4a / 100005227
• ZFINID: ZDB-GENE-060503-275
• Length: 618
• Species: Danio rerio
• Alignment Length: 382
• Identity: 116/382 - (30%)
• Similarity: 176/382 - (46%)
• Gaps: 48/382 - (12%)

  Fly    38 TTAFCPSKCQCLGGEANSRAL----CVDAALEDVPIQLNPETKYINLTVNRIRTLE----FSLPF 94
            |:..|..:|.|      |..|    |....|..||..:...|:.:|||.|.::||.    |||
Zfish    38 TSGPCAQRCDC------SPKLPLVDCSSQQLSAVPEGVPDATQVLNLTYNHLKTLSSRQFFSL-- 94

  Fly    95 YMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLSFNRIETV 159
             .:|..||||.|::..:..:.|.....|.||.||||.:..:...||.||.|:..||:|.|.|..:
Zfish    95 -RQLRELDLSANMLTVIEVEAFVGLQNLITLRLSRNRLKIIPVGAFSGLPNVQFLDISENEILVL 158

  Fly   160 HPTALSDLASLVELDLTNNNIVSLEDNCFKGM-NTLEVLVFRNNRLLDVPASNLWHLHALKSLDM 223
            ......::.||.:|:.:.|::|.:.:..|.|: |.||:.:.|.| |..||:.....|..|:.|..
Zfish   159 LDDMFGEMPSLQKLEASENDLVFISNRAFSGLPNLLELRLERCN-LTTVPSEAFSRLTGLQHLRF 222

  Fly   224 SLNLVEFVRNDSFEGLKELLALSV-QGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQQLSKL 287
            ....:..:.|:||..|:.|..|.| :...:..|.:::..|| :|..|.||..||:.||...|..|
Zfish   223 CRLGLTALPNNSFRQLQRLQDLHVSRCPWLHTLAVNSLIGL-NLTSLTLSHCNLSAVPYAPLHHL 286

  Fly   288 SNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNNPQLSD 352
            ..|.||:|..|..:.:.:....:|..|:||||.....| .::|.||.:....:.|::::
Zfish   287 VYLRYLDLSYNPITTVLSGLLGDLLRLQELHLVSTGLL-HVESGAFRNLAFFRLLNVSD------ 344

  Fly   353 IPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCSLLWLWR 408
                               |.|.||..:.| .|..|:.|.|..|||.|:|.|||:.|
Zfish   345 -------------------NRLVTLEESAFHAVGSLEVLRLDGNPLACDCRLLWVMR 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	88/282 (31%)
		leucine-rich repeat	75..97	CDD:275378	10/25 (40%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		leucine-rich repeat	122..145	CDD:275380	11/22 (50%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		leucine-rich repeat	170..193	CDD:275380	6/23 (26%)
		leucine-rich repeat	194..217	CDD:275380	8/22 (36%)
		leucine-rich repeat	218..265	CDD:275380	12/47 (26%)
		leucine-rich repeat	266..289	CDD:275380	10/22 (45%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..338	CDD:275380	9/23 (39%)
		LRR_8	337..397	CDD:404697	11/60 (18%)
		leucine-rich repeat	339..360	CDD:275380	1/20 (5%)
lingo4a	NP_001076447.1	LRRNT	41..70	CDD:214470	9/34 (26%)
		leucine-rich repeat	52..72	CDD:275380	5/19 (26%)
		leucine-rich repeat	73..96	CDD:275380	10/25 (40%)
		LRR	75..379	CDD:443914	102/334 (31%)
		leucine-rich repeat	97..120	CDD:275380	7/22 (32%)
		leucine-rich repeat	121..144	CDD:275380	11/22 (50%)
		leucine-rich repeat	145..168	CDD:275380	5/22 (23%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		leucine-rich repeat	193..216	CDD:275380	8/23 (35%)
		leucine-rich repeat	217..240	CDD:275380	6/22 (27%)
		leucine-rich repeat	241..288	CDD:275380	16/47 (34%)
		leucine-rich repeat	289..310	CDD:275380	5/20 (25%)
		leucine-rich repeat	313..336	CDD:275380	9/23 (39%)
		leucine-rich repeat	337..356	CDD:275380	5/43 (12%)
		Ig	424..512	CDD:472250
		Ig strand B	442..446	CDD:409353
		Ig strand C	455..459	CDD:409353
		Ig strand E	478..482	CDD:409353
		Ig strand F	492..497	CDD:409353
		Ig strand G	505..508	CDD:409353