Protein Alignment Snoo and SKOR1

DIOPT Version :10

• Sequence 1: NP_609164.3
• Gene: Snoo / 5740414
• FlyBaseID: FBgn0085450
• Length: 1223
• Species: Drosophila melanogaster
• Sequence 2: NP_001352844.1
• Gene: SKOR1 / 390598
• HGNCID: 21326
• Length: 965
• Species: Homo sapiens
• Alignment Length: 1318
• Identity: 252/1318 - (19%)
• Similarity: 380/1318 - (28%)
• Gaps: 510/1318 - (38%)

  Fly    13 LKKYQTSATKSLQGPG----HALTTAGVLDIVTNGRSESPGLNGKCQASPPVVALIKKEILSSPE 73
            |:.:.:..::|..|.|    .|...:|.::.:|.  ...||..|.                |||.
Human    12 LRIWVSLPSQSENGIGFLAARAFLRSGGMEALTT--QLGPGREGS----------------SSPN 58

  Fly    74 PQDLHHHECSTRGTPPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMRLC 138
                     |.:...|...|.|..|.::.               ||.|.|..|....:.|:.|||
Human    59 ---------SKQELQPYSGSSALKPNQVG---------------ETSLYGVPIVSLVIDGQERLC 99

  Fly   139 LPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDVKASGLITRTDAERLCA 203
            |.|..|.:|.::|..:|:.....|||.|.|||..||...:.|..:|...:..|:||:.:|||||.
Human   100 LAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCK 164

  Fly   204 ALL--HRSDRNSYVPIESLAKGALSFHVYHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQ 266
            :.|  |:..:   :| |:.|     |.|.|:|.....|...|..|:..:..||||..|..:|||.
Human   165 SFLGEHKPPK---LP-ENFA-----FDVVHECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPN 220

  Fly   267 KFVGHVHRKFENHTCHWGFDSRNWHDYLHVALDVENREKYQIILDQLKEVELKEMHKAQRELEHK 331
            ||:.|.||.               .|..:...|..|...::      :.::|.: ..|..||.|.
Human   221 KFIFHSHRT---------------PDAKYTQPDAANFNSWR------RHLKLSD-KSATDELSHA 263

  Fly   332 KRKAEMLMDDGML----------GSGPVLGLAGHPHGLVGA-----------LAP---------- 365
            ....:.:.:.|..          |.|...|..|...|..|.           :||
Human   264 WEDVKAMFNGGTRKRTFSLQGGGGGGANGGSGGQGKGGAGGGGGGGPGCGAEMAPGPPPHKSLRC 328

  Fly   366 -------PPPPPMKQPQMDI--------------PSGKKQLQQLKGATVAASALEYQYQVMYAHC 409
                   ||.||...||..:              |.|        ||.|.:      |.|:
Human   329 GEDEAAGPPGPPPPHPQRGLGLATGASGPAGPGGPGG--------GAGVRS------YPVI---- 375

  Fly   410 VQKEREREREHLPHSHPLPRQHRAVLVATTP--YPHLPQYPT---------PPTLNSSSAFRPWG 463
                            |:|.:...:|....|  :||...:||         .|.|.:...  ..|
Human   376 ----------------PVPSKGFGLLQKLPPPLFPHPYGFPTAFGLCPKKDDPVLGAGEP--KGG 422

  Fly   464 PDTTKAFLHAYGATLSSLPYACQEPPEL-QNPERVVRSTDKRYAERTYQPNVALAPRKSILSKER 527
            |.|......|.....:..|.|...||.. ..|........       :||:.|.
Human   423 PGTGSGGGGAGTGGGAGGPGASHLPPGAGAGPGGGAMFWG-------HQPSGAA----------- 469

  Fly   528 DKDRERMEREVMERQRLREKETDHQVVHIKQERSQTPTPPTASPPDGVVLPLDVVEPPHPSSSGS 592
             ||..                   .|.......:..||.|...|..| .||:    |.:|::...
Human   470 -KDAA-------------------AVAAAAAAATVYPTFPMFWPAAG-SLPV----PSYPAAQSQ 509

  Fly   593 NSPLPAHLPAAPATAPPNAGGAPPTPTNLRNMRSPEEFSAGGSNEITSSTS--PHHQQSSHHQVV 655
            ...:.|.:.||.|.|...||...|.|  |......:|...|......|:.|  |..:..:...:.
Human   510 AKAVAAAVAAAAAAAAAAAGSGAPEP--LDGAEPAKESGLGAEERCPSALSRGPLDEDGTDEALP 572

  Fly   656 QPTAGAPPPSQHIIATVNQHAKLLPSSSSLPNGNGSSSLAATNNEPSRIRINKNLMSQQPVV--- 717
            .|.|..|||                                   .|...|....:.:.:|||
Human   573 PPLAPLPPP-----------------------------------PPPPARKGSYVSAFRPVVKDT 602

  Fly   718 -AVSGMTPHHHQHHPTHMHHFSHGYYKSQASSPTQSSSAGLNLSTHSSNVVSSPHHATQPKTHHS 781
             :::.:.....:           .|....|..|...:.:|..:|....:..||.:::..|
Human   603 ESIAKLYGSARE-----------AYGAGPARGPGPGAGSGGYVSPDFLSEGSSSYNSASP----- 651

  Fly   782 SVGSGNHGLQNGKPHLGSEFELSTDTDDTDSLNGEPDSSAMLPPWEQAVESLRETRPKDRERVLL 846
                                    |.|..|    ||:
Human   652 ------------------------DVDTAD----EPE---------------------------- 660

  Fly   847 ILQRLLQENDQYRYNNIQLSELLHKQDAHIADLTEQLQRYRRQFEEQVCKVDLRKMPFKHQTRLE 911
                                                              ||
Human   661 --------------------------------------------------VD------------- 662

  Fly   912 NVVEAGRGEAEEDEELEEDEMEDRANNNNQQELSPLIKAPANG----LRRSVTPPNCCAS-EGGD 971
              ||:.|...:||.               |:|..|  .||:.|    ..:...||:..:| ..|.
Human   663 --VESNRFPDDEDA---------------QEETEP--SAPSAGGGPDGEQPTGPPSATSSGADGP 708

  Fly   972 CEKPD--EPESKRIKLQVGE-----------KAEDKQVENEESPSNGTESHDLEK---------- 1013
            ...||  .|..:|   ::|.           .|||.....|.||.:|...::|.:
Human   709 ANSPDGGSPRPRR---RLGPPPAGRPAFGDLAAEDLVRRPERSPPSGGGGYELREPCGPLGGPAP 770

  Fly  1014 ----LEKNDDKTDPTNNPKSPQPSQISSDDEMEEDDEDEDEEDEDEEVQVEAPHSSALATPPTAT 1074
                ..:.|:..........|..|.:.:.:..|.|.||.....:|.|.:...|...:::.|..|.
Human   771 AKVFAPERDEHVKSAAVALGPAASYVCTPEAHEPDKEDNHSPADDLETRKSYPDQRSISQPSPAN 835

  Fly  1075 TPLSPDSAATAGQLFDSSNSSDESSMKKAQMSACHALEKMSSNVGSDENNQRLAE---------- 1129
            |....|     |...|              ::..|.:||...|:..:|..:.|.|
Human   836 TDRGED-----GLTLD--------------VTGTHLVEKDIENLAREELQKLLLEQMELRKKLER 881

  Fly  1130 --ESQEDEAEEDPEEEDSDDDEMPLQQRQ-----------QQQRQRVAPQNVLSGPSVAGHH--- 1178
              :|.:|..::..:.|.:..:|| :||.|           |:::.|.|.|..|.....|.||
Human   882 EFQSLKDNFQDQMKRELAYREEM-VQQLQIVRDTLCNELDQERKARYAIQQKLKEAHDALHHFSC 945

  Fly  1179 --PAPAH--------PPM 1186
              ..|.|        ||:
Human   946 KMLTPRHCTGNCSFKPPL 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snoo	NP_609164.3	DHD_Ski_Sno	116..206	CDD:410782	34/89 (38%)
		c-SKI_SMAD_bind	226..317	CDD:198114	23/90 (26%)
		AF-4	637..>789	CDD:461550	21/157 (13%)
SKOR1	NP_001352844.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..72		9/53 (17%)
		DHD_Skor	77..167	CDD:410783	34/104 (33%)
		c-SKI_SMAD_bind	180..272	CDD:198114	29/118 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	278..367		16/96 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..458		11/49 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	530..592		15/98 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..777		43/307 (14%)
		PRK07764	<659..846	CDD:236090	46/304 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	796..843		11/51 (22%)
		OmpH	861..>936	CDD:461098	16/75 (21%)