DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34274 and TOM70

DIOPT Version :9

Sequence 1:	NP_001097807.1	Gene:	CG34274 / 5740212	FlyBaseID:	FBgn0085303	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_014278.3	Gene:	TOM70 / 855602	SGDID:	S000005065	Length:	617	Species:	Saccharomyces cerevisiae

Alignment Length:	192	Identity:	45/192 - (23%)
Similarity:	86/192 - (44%)	Gaps:	21/192 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 NKTDSSKKR-QKSTITMDDIKCIVTRRSAVSTTTFRRGKAKRALINTNQFTFMRQIDSEPDDRVL 124
            |:....::| :|:||..|:.|  .|:.|...|.     .||::...:|...:....:.|||....
Yeast    30 NQLQQQQQRGKKNTINKDEKK--DTKDSQKETE-----GAKKSTAPSNPPIYPVSSNGEPDFSNK 87

  Fly   125 AR---EQREDVAETFRRMGNYEYRKLNFSLAKDYYSKGIQYIKDSPVLYVNRALCFIKLREFKLG 186
            |.   |:::..|...:..||..:|...:..|..||:..:: :|:.||.|.|.:.|::.:.:.| .
Yeast    88 ANFTAEEKDKYALALKDKGNQFFRNKKYDDAIKYYNWALE-LKEDPVFYSNLSACYVSVGDLK-K 150

  Fly   187 IIDCDYVLAKIDEHYLRAWLYRAAAYKRLND--EPNFEYSVDRARRFNRSDADFIDEFLDKM 246
            :::......::...|.:..|.||:|.:.|..  :..|:.||      ...:.||.|..::.|
Yeast   151 VVEMSTKALELKPDYSKVLLRRASANEGLGKFADAMFDLSV------LSLNGDFNDASIEPM 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34274	NP_001097807.1	TPR_11	133..195	CDD:290150	14/61 (23%)
		TPR repeat	133..161	CDD:276809	7/27 (26%)
		TPR repeat	166..197	CDD:276809	6/30 (20%)
TOM70	NP_014278.3	3a0801s09	1..614	CDD:273380	45/192 (23%)
		TPR repeat	99..127	CDD:276809	7/27 (26%)
		TPR repeat	131..161	CDD:276809	6/30 (20%)
		TPR repeat	166..189	CDD:276809	6/22 (27%)
		TPR repeat	330..358	CDD:276809
		TPR repeat	363..391	CDD:276809
		TPR repeat	396..426	CDD:276809
		TPR repeat	431..459	CDD:276809
		TPR repeat	465..493	CDD:276809
		TPR repeat	498..537	CDD:276809
		TPR repeat	542..567	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870