DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34274 and STI1

DIOPT Version :9

Sequence 1:	NP_001097807.1	Gene:	CG34274 / 5740212	FlyBaseID:	FBgn0085303	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_014670.1	Gene:	STI1 / 854192	SGDID:	S000005553	Length:	589	Species:	Saccharomyces cerevisiae

Alignment Length:	335	Identity:	63/335 - (18%)
Similarity:	110/335 - (32%)	Gaps:	124/335 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PLTTNTVDKKNEHEKPFGLEIPKPELFIYQHPAADESFLKEQPTKVEDVIEYLDVLENANKTDSS 66
            |.|:.:.::|.:.|                 |.:|.:..||..:|             |.:.:.|
Yeast   211 PETSKSTEQKKDAE-----------------PQSDSTTSKENSSK-------------APQKEES 245

  Fly    67 KKRQKSTITMDDIKCIVTRRSAVSTTTFRRGKAKRALINTNQ-------FTFMRQ---------- 114
            |:.:...:..||.|....:..|.....::..:...|:.:.|:       .|::..
Yeast   246 KESEPMEVDEDDSKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKDITYLNNRAAAEYEKGE 310

  Fly   115 ----IDSEPDDRVLAREQRED---VAETFRRMGNYEYRKLNFSLAK--DYYSKGIQYIKDSPVL- 169
                |.:..|.....||.|.|   ::::|.|:|| .|.||. .|.|  :||.|.:...:.:.:|
Yeast   311 YETAISTLNDAVEQGREMRADYKVISKSFARIGN-AYHKLG-DLKKTIEYYQKSLTEHRTADILT 373

  Fly   170 -----------------------------------------------------------YVNRAL 175
                                                                       |.|||.
Yeast   374 KLRNAEKELKKAEAEAYVNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAA 438

  Fly   176 CFIKLREFKLGIIDCDYVLAKIDEHYLRAWLYRAAAYKRLNDEPNFEYSVDRARR-----FNRSD 235
            ...||..|...|.||:..:.| |.:::||::.:|.|...:.:..:...::|.||.     .|.|.
Yeast   439 ALAKLMSFPEAIADCNKAIEK-DPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVNNGSS 502

  Fly   236 ADFIDEFLDK 245
            |..||:...|
Yeast   503 AREIDQLYYK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34274	NP_001097807.1	TPR_11	133..195	CDD:290150	23/123 (19%)
		TPR repeat	133..161	CDD:276809	12/29 (41%)
		TPR repeat	166..197	CDD:276809	11/90 (12%)
STI1	NP_014670.1	PLN03088	5..>106	CDD:215568
		TPR repeat	5..33	CDD:276809
		TPR repeat	39..69	CDD:276809
		TPR repeat	74..102	CDD:276809
		STI1	138..193	CDD:407696
		3a0801s09	203..>573	CDD:273380	63/335 (19%)
		TPR repeat	262..290	CDD:276809	3/27 (11%)
		TPR repeat	294..324	CDD:276809	3/29 (10%)
		TPR repeat	336..363	CDD:276809	12/28 (43%)
		PLN03088	396..>549	CDD:215568	25/118 (21%)
		TPR repeat	396..424	CDD:276809	0/27 (0%)
		TPR repeat	429..459	CDD:276809	10/29 (34%)
		TPR repeat	464..490	CDD:276809	5/25 (20%)
		STI1	527..581	CDD:407696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810