DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34274 and si:dkey-33c12.4

DIOPT Version :9

Sequence 1:	NP_001097807.1	Gene:	CG34274 / 5740212	FlyBaseID:	FBgn0085303	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	XP_021336269.1	Gene:	si:dkey-33c12.4 / 560112	ZFINID:	ZDB-GENE-030131-2527	Length:	648	Species:	Danio rerio

Alignment Length:	255	Identity:	51/255 - (20%)
Similarity:	101/255 - (39%)	Gaps:	63/255 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VDKKN---EHEKPFGLEIPKPELFIYQHPAADE------------SFLKEQPTKVEDVIEYLDVL 57
            ::|:|   |..||..:: |.||.  .:|...|.            |.:...|..:...:...|
Zfish   165 LEKENANKEKNKPVQVD-PGPEK--TKHADKDNENKDKKCKNKGCSSVPPDPQPISAPVSSSD-- 224

  Fly    58 ENANKTDSSKKRQKSTITMDDI---KCIVTRRSAVSTTTFRRGKAKRAL-------INTNQFTFM 112
              ::..:...|::.|.|..:::   .|.|:..:|:         |||.|       ....|....
Zfish   225 --SSSDEEDDKKEDSAIEPEELDMNSCFVSNAAAI---------AKRKLEQKPKPDKKPAQANPK 278

  Fly   113 RQIDSEPDDRVLAREQ--REDV-------AETF-------RRMGNYEYRKLNFSLAKDYYSKGIQ 161
            :|.:|:....|:.::|  :|:|       |..|       ..:||......|..:|..|::..|:
Zfish   279 KQHESQQKATVMPQKQVAKEEVNGEESVNANDFITRSVELAVIGNEYAGSGNMEMAVKYFTDAIK 343

  Fly   162 YIKDSPVLYVNRALCFIKLREFKLGIIDCDYVLAKIDEHYLRAWLYR----AAAYKRLND 217
            :......|:.||:.|:.|:.:::..:.|.:..|: ::..:::. |||    ....||.|:
Zfish   344 HNPKEYKLFGNRSYCYEKMLQYEKSLTDAEIALS-MNPKWIKG-LYRKGRALVGLKRYNE 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34274	NP_001097807.1	TPR_11	133..195	CDD:290150	14/68 (21%)
		TPR repeat	133..161	CDD:276809	7/34 (21%)
		TPR repeat	166..197	CDD:276809	7/30 (23%)
si:dkey-33c12.4	XP_021336269.1	PLN03088	258..>439	CDD:330826	32/146 (22%)
		TPR repeat	348..378	CDD:276809	7/30 (23%)
		TPR repeat	383..411	CDD:276809	6/20 (30%)
		UBA	430..456	CDD:270456
		RRM	<471..>614	CDD:223796
		RRM	519..584	CDD:214636
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900