DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34274 and TTC12

DIOPT Version :9

Sequence 1:	NP_001097807.1	Gene:	CG34274 / 5740212	FlyBaseID:	FBgn0085303	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	XP_005271661.1	Gene:	TTC12 / 54970	HGNCID:	23700	Length:	777	Species:	Homo sapiens

Alignment Length:	203	Identity:	48/203 - (23%)
Similarity:	96/203 - (47%)	Gaps:	30/203 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ESFLKEQPTKVEDVIEYLDVLENANKTDSSKKRQKSTI-----------TMDDIKCIVT-RRSAV 89
            :.|||       :|.|..::::..| :|....:||:.:           ..::.:|..| .::.:
Human    10 QKFLK-------NVDEISNLIQEMN-SDDPVVQQKAVLETEKRLLLMEEDQEEDECRTTLNKTMI 66

  Fly    90 STTTFRRGKAKRALINTNQFTFMRQIDSEPDDRVLAREQREDVAETFRRMGNYEYRKLNFSLAKD 154
            |...    .|.::....|...|:..::.:..:|...|.:.:.:|:..:..||..:.:.|:..|..
Human    67 SPPQ----TAMKSAEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAIL 127

  Fly   155 YYSKGIQYIKDSPVLYVNRALCFIKLREFKLGIIDCDYVLAKIDEHYLRAWLYRAAAYKRLNDEP 219
            .||:|::.:||..|||.|||..::||.:::..::||::.| |.||...:|:.:...|...|.:
Human   128 RYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWAL-KCDEKCTKAYFHMGKANLALKN-- 189

  Fly   220 NFEYSVDR 227
               |||.|
Human   190 ---YSVSR 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34274	NP_001097807.1	TPR_11	133..195	CDD:290150	20/61 (33%)
		TPR repeat	133..161	CDD:276809	8/27 (30%)
		TPR repeat	166..197	CDD:276809	11/30 (37%)
TTC12	XP_005271661.1	TPR_11	106..171	CDD:290150	22/65 (34%)
		BamD	106..>164	CDD:276939	19/57 (33%)
		TPR repeat	106..138	CDD:276939	8/31 (26%)
		TPR repeat	106..134	CDD:276809	8/27 (30%)
		TPR repeat	139..169	CDD:276809	11/30 (37%)
		TPR_11	142..205	CDD:290150	20/59 (34%)
		TPR_1	143..173	CDD:278916	12/30 (40%)
		TPR repeat	174..202	CDD:276809	7/26 (27%)
		TPR repeat	211..236	CDD:276809
		ARM	526..631	CDD:237987
		armadillo repeat	555..591	CDD:293788
		armadillo repeat	597..631	CDD:293788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11583
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005389
OrthoInspector	1	1.000	-	-		otm40328
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.810