Protein Alignment CG34274 and TTC12

DIOPT Version :10

• Sequence 1: NP_001097807.1
• Gene: CG34274 / 5740212
• FlyBaseID: FBgn0085303
• Length: 250
• Species: Drosophila melanogaster
• Sequence 2: NP_001305462.1
• Gene: TTC12 / 54970
• HGNCID: 23700
• Length: 711
• Species: Homo sapiens
• Alignment Length: 208
• Identity: 47/208 - (22%)
• Similarity: 96/208 - (46%)
• Gaps: 34/208 - (16%)

  Fly    37 ESFLKEQPTKVEDVIEYLDVLENANKTDSSKKRQKSTI-----------TMDDIKCIVT-RRSAV 89
            :.|||       :|.|..::::..| :|....:||:.:           ..::.:|..| .::.:
Human    10 QKFLK-------NVDEISNLIQEMN-SDDPVVQQKAVLETEKRLLLMEEDQEEDECRTTLNKTMI 66

  Fly    90 STTTFRRGKAKRALINTNQFTFMRQIDSEPDDRVLAREQREDVAETFRRMGNYEYRKLNFSLAKD 154
            |...    .|.::....|...|:..::.:..:|...|.:.:.:|:..:..||..:.:.|:..|..
Human    67 SPPQ----TAMKSAEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAIL 127

  Fly   155 YYSKGIQYIKDSPVLYVNRALCFIKLREFKLGIIDCDYVL-----AKIDEHYLRAWLYRAAAYKR 214
            .||:|::.:||..|||.|||..::||.:::..::||::.|     .:.||...:|:.:...|...
Human   128 RYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSFSFMQCDEKCTKAYFHMGKANLA 192

  Fly   215 LNDEPNFEYSVDR 227
            |.:     |||.|
Human   193 LKN-----YSVSR 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34274	NP_001097807.1	3a0801s09	118..>215	CDD:273380	27/101 (27%)
		TPR repeat	133..161	CDD:276809	8/27 (30%)
		TPR repeat	166..197	CDD:276809	11/35 (31%)
TTC12	NP_001305462.1	TPR	105..>212	CDD:440225	30/101 (30%)
		TPR 1	106..139		9/32 (28%)
		TPR repeat	106..134	CDD:276809	8/27 (30%)
		TPR repeat	139..175	CDD:276809	11/35 (31%)
		TPR 3	180..213		7/26 (27%)
		TPR repeat	180..208	CDD:276809	7/26 (27%)
		TPR repeat	217..242	CDD:276809
		armadillo repeat	561..597	CDD:293788
		armadillo repeat	603..637	CDD:293788