DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34274 and Ttc12

DIOPT Version :9

Sequence 1:	NP_001097807.1	Gene:	CG34274 / 5740212	FlyBaseID:	FBgn0085303	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_766358.1	Gene:	Ttc12 / 235330	MGIID:	2444588	Length:	704	Species:	Mus musculus

Alignment Length:	178	Identity:	42/178 - (23%)
Similarity:	88/178 - (49%)	Gaps:	9/178 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VEDVIEYLDVLENANKTDSSKKRQKSTITMDDIKCIVTR-------RSAVSTTTFRRGKAKRALI 104
            :|:|.|...:::..| :|....:||:.:..:....::.|       |:.::.|.....:......
Mouse    13 LENVDEITSLIQEMN-SDDPFIQQKAVLDSEKKLLLMEREQEEDGCRTTLNKTMISPPQTPENAD 76

  Fly   105 NTNQFTFMRQIDSEPDDRVLAREQREDVAETFRRMGNYEYRKLNFSLAKDYYSKGIQYIKDSPVL 169
            ..:...|:..::.:..:|...|.:...:|:..:..||..:.:.::..|..:||:|:..:||..||
Mouse    77 EMSPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVRGDYETAIFFYSEGLGKLKDMKVL 141

  Fly   170 YVNRALCFIKLREFKLGIIDCDYVLAKIDEHYLRAWLYRAAAYKRLND 217
            |.|||..||||.:::..::|||:.| |.||:..:|:.:...|:..|.:
Mouse   142 YTNRAQAFIKLGDYQKALVDCDWAL-KCDENCTKAYFHMGKAHVALKN 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34274	NP_001097807.1	TPR_11	133..195	CDD:290150	22/61 (36%)
		TPR repeat	133..161	CDD:276809	7/27 (26%)
		TPR repeat	166..197	CDD:276809	14/30 (47%)
Ttc12	NP_766358.1	TPR_11	105..170	CDD:290150	24/65 (37%)
		TPR 1	105..138		8/32 (25%)
		TPR repeat	105..133	CDD:276809	7/27 (26%)
		TPR repeat	138..168	CDD:276809	14/30 (47%)
		TPR 2	139..172		17/33 (52%)
		TPR_11	141..204	CDD:290150	19/49 (39%)
		TPR_1	142..172	CDD:278916	15/30 (50%)
		TPR 3	173..206		3/16 (19%)
		TPR repeat	173..198	CDD:276809	3/16 (19%)
		TPR_1	174..205	CDD:278916	3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11152
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005389
OrthoInspector	1	1.000	-	-		otm42394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810