DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34274 and TTC28

DIOPT Version :9

Sequence 1:	NP_001097807.1	Gene:	CG34274 / 5740212	FlyBaseID:	FBgn0085303	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001138890.1	Gene:	TTC28 / 23331	HGNCID:	29179	Length:	2481	Species:	Homo sapiens

Alignment Length:	206	Identity:	48/206 - (23%)
Similarity:	74/206 - (35%)	Gaps:	65/206 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RQKSTITMDDIKCIVTRRSAVSTTTFRRGKAKRALINTNQFTFMRQIDSEPDDRVL--------- 124
            ||:..|:|:     |..|::.::|......|.:||              ...||.|
Human   538 RQELQISME-----VNDRASQASTHGNLAVAYQAL--------------GAHDRALQHYQNHLNI 583

  Fly   125 AREQR--EDVAETFRRMGNYEYRKLNFSLAKDYYSKGIQYIKDSPVL--------------YVNR 173
            |||.|  :..|.....:||:...:..:..|..||.   ||::.:|.|              |.:
Human   584 ARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYE---QYLRLAPDLQDMEGEGKVCHNLGYAH- 644

  Fly   174 ALCFIKLREFKLGIIDCDYVLAKIDEH----YLRAWLYRAAAYKRLNDEPNF-------EYSVDR 227
             .|....:| .:...:.|..||| |.|    ..:|:.....|:|.|   .||       :|.:..
Human   645 -YCLGNYQE-AVKYYEQDLALAK-DLHDKLSQAKAYCNLGLAFKAL---LNFSKAEECQKYLLSL 703

  Fly   228 ARRFNRSDADF 238
            |:..|.|.|.|
Human   704 AQSLNNSQAKF 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34274	NP_001097807.1	TPR_11	133..195	CDD:290150	14/75 (19%)
		TPR repeat	133..161	CDD:276809	6/27 (22%)
		TPR repeat	166..197	CDD:276809	8/44 (18%)
TTC28	NP_001138890.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		TPR 1	58..91
		TPR_11	63..123	CDD:290150
		TPR repeat	91..121	CDD:276809
		TPR 2	93..125
		TPR_11	94..157	CDD:290150
		TPR 3	126..159
		TPR repeat	126..154	CDD:276809
		TPR repeat	160..188	CDD:276809
		TPR 4	196..229
		TPR 5	234..267
		TPR repeat	236..262	CDD:276809
		TPR 6	274..307
		TPR repeat	274..306	CDD:276809
		TPR_11	275..345	CDD:290150
		TPR 7	314..347
		TPR_12	315..386	CDD:290160
		TPR repeat	316..342	CDD:276809
		TPR 8	354..387
		TPR repeat	354..382	CDD:276809
		TPR_7	357..391	CDD:289919
		TPR repeat	393..423	CDD:276809
		TPR 9	394..427
		TPR	394..426	CDD:197478
		TPR	414..717	CDD:223533	48/206 (23%)
		TPR repeat	428..459	CDD:276809
		TPR 10	434..467
		TPR 11	474..507
		TPR repeat	475..502	CDD:276809
		TPR 12	514..547		4/13 (31%)
		TPR repeat	515..542	CDD:276809	2/3 (67%)
		TPR_7	516..551	CDD:289919	5/17 (29%)
		TPR 13	554..587		9/46 (20%)
		TPR repeat	554..582	CDD:276809	7/41 (17%)
		TPR 14	594..627		9/35 (26%)
		TPR repeat	594..622	CDD:276809	8/30 (27%)
		TPR_7	596..631	CDD:289919	9/37 (24%)
		TPR repeat	633..663	CDD:276809	4/32 (13%)
		TPR 15	634..667		7/36 (19%)
		TPR_7	636..670	CDD:289919	9/37 (24%)
		TPR 16	674..707		8/35 (23%)
		TPR	694..995	CDD:223533	6/21 (29%)
		TPR repeat	712..739	CDD:276809	2/3 (67%)
		TPR 17	714..747		1/1 (100%)
		TPR 18	754..787
		TPR repeat	754..782	CDD:276809
		TPR 19	794..827
		TPR repeat	794..822	CDD:276809
		TPR repeat	833..863	CDD:276809
		TPR 20	834..867
		TPR 21	877..910
		TPR repeat	878..905	CDD:276809
		TPR_7	879..911	CDD:289919
		TPR repeat	916..950	CDD:276809
		TPR 22	917..950
		TPR 23	957..990
		TPR repeat	957..982	CDD:276809
		TPR_7	959..994	CDD:289919
		TPR 24	997..1030
		TPR repeat	997..1025	CDD:276809
		TPR_12	999..1067	CDD:290160
		TPR 25	1037..1070
		TPR repeat	1037..1065	CDD:276809
		TPR_12	1038..1109	CDD:290160
TPR repeat	1075..1105	CDD:276809
TPR 26	1077..1110
TPR_12	1079..1148	CDD:290160
TPR 27	1117..1150
TPR repeat	1117..1143	CDD:276809
TPR 28	1169..1202
TPR repeat	1169..1194	CDD:276809
CHAT	1390..1713	CDD:289536
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2004..2055
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2075..2161
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2339
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2420..2467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0548
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900