DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34274 and TTC28

DIOPT Version :10

Sequence 1:NP_001097807.1 Gene:CG34274 / 5740212 FlyBaseID:FBgn0085303 Length:250 Species:Drosophila melanogaster
Sequence 2:NP_001138890.1 Gene:TTC28 / 23331 HGNCID:29179 Length:2481 Species:Homo sapiens


Alignment Length:206 Identity:48/206 - (23%)
Similarity:74/206 - (35%) Gaps:65/206 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 RQKSTITMDDIKCIVTRRSAVSTTTFRRGKAKRALINTNQFTFMRQIDSEPDDRVL--------- 124
            ||:..|:|:     |..|::.::|......|.:||              ...||.|         
Human   538 RQELQISME-----VNDRASQASTHGNLAVAYQAL--------------GAHDRALQHYQNHLNI 583

  Fly   125 AREQR--EDVAETFRRMGNYEYRKLNFSLAKDYYSKGIQYIKDSPVL--------------YVNR 173
            |||.|  :..|.....:||:...:..:..|..||.   ||::.:|.|              |.: 
Human   584 ARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYE---QYLRLAPDLQDMEGEGKVCHNLGYAH- 644

  Fly   174 ALCFIKLREFKLGIIDCDYVLAKIDEH----YLRAWLYRAAAYKRLNDEPNF-------EYSVDR 227
             .|....:| .:...:.|..||| |.|    ..:|:.....|:|.|   .||       :|.:..
Human   645 -YCLGNYQE-AVKYYEQDLALAK-DLHDKLSQAKAYCNLGLAFKAL---LNFSKAEECQKYLLSL 703

  Fly   228 ARRFNRSDADF 238
            |:..|.|.|.|
Human   704 AQSLNNSQAKF 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34274NP_001097807.1 3a0801s09 118..>215 CDD:273380 29/125 (23%)
TPR repeat 133..161 CDD:276809 6/27 (22%)
TPR repeat 166..197 CDD:276809 8/44 (18%)
TTC28NP_001138890.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48
PEP_TPR_lipo 47..937 CDD:274350 48/206 (23%)
TPR 1 58..91
TPR repeat 91..121 CDD:276809
TPR 2 93..125
TPR 3 126..159
TPR repeat 126..154 CDD:276809
TPR repeat 160..188 CDD:276809
TPR 4 196..229
TPR 5 234..267
TPR repeat 236..262 CDD:276809
TPR 6 274..307
TPR repeat 274..306 CDD:276809
TPR 7 314..347
TPR repeat 316..342 CDD:276809
TPR 8 354..387
TPR repeat 354..382 CDD:276809
TPR repeat 393..423 CDD:276809
TPR 9 394..427
TPR repeat 428..459 CDD:276809
TPR 10 434..467
TPR 11 474..507
TPR repeat 475..502 CDD:276809
TPR 12 514..547 4/13 (31%)
TPR 515..774 CDD:440225 48/206 (23%)
TPR repeat 515..542 CDD:276809 2/3 (67%)
TPR 13 554..587 9/46 (20%)
TPR repeat 554..582 CDD:276809 7/41 (17%)
TPR 14 594..627 9/35 (26%)
TPR repeat 594..622 CDD:276809 8/30 (27%)
TPR repeat 633..663 CDD:276809 4/32 (13%)
TPR 15 634..667 7/36 (19%)
TPR 16 674..707 8/35 (23%)
TPR repeat 712..739 CDD:276809 2/3 (67%)
TPR 17 714..747 1/1 (100%)
TPR 18 754..787
TPR repeat 754..782 CDD:276809
TPR 19 794..827
TPR repeat 794..822 CDD:276809
TPR repeat 833..863 CDD:276809
TPR 20 834..867
TPR 21 877..910
TPR repeat 878..905 CDD:276809
TPR repeat 916..950 CDD:276809
TPR 22 917..950
COG4995 947..1713 CDD:444019
TPR 23 957..990
TPR repeat 957..982 CDD:276809
TPR 24 997..1030
TPR repeat 997..1025 CDD:276809
TPR 25 1037..1070
TPR repeat 1037..1065 CDD:276809
TPR repeat 1075..1105 CDD:276809
TPR 26 1077..1110
TPR 27 1117..1150
TPR repeat 1117..1143 CDD:276809
TPR 28 1169..1202
TPR repeat 1169..1194 CDD:276809
CHAT 1390..1713 CDD:432771
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2004..2055
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2161
Herpes_BLLF1 <2088..>2336 CDD:282904
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2339
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2420..2467
Blue background indicates that the domain is not in the aligned region.

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