DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clos and tspeara

DIOPT Version :9

Sequence 1:	NP_001097246.3	Gene:	clos / 5740204	FlyBaseID:	FBgn0261016	Length:	1836	Species:	Drosophila melanogaster
Sequence 2:	XP_698991.2	Gene:	tspeara / 570420	ZFINID:	ZDB-GENE-120215-12	Length:	676	Species:	Danio rerio

Alignment Length:	361	Identity:	85/361 - (23%)
Similarity:	138/361 - (38%)	Gaps:	116/361 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LDICILQLPTV-KYATALH---KNAAGVRHFAVYTWRPAEQDYQLLVELETPKAVALDCLAFAGR 135
            |||.:.|:|:| .:|...|   |..:|     :|.|  :...:||...:.|.||.|........:
Zfish   334 LDIELFQIPSVGLFAAMAHRATKPGSG-----IYRW--SHGHFQLYQNISTFKAQAWKQFTIGKK 391

  Fly   136 GYVAVSYNLTEPVSQAREGSPIYEISPETGIRTVQYFSGTHLRGMYLRISSQELTLLHAFESNAQ 200
            .::||| |...|.    :|.|                               ||:::
Zfish   392 MFLAVS-NSMGPA----DGEP-------------------------------ELSVV-------- 412

  Fly   201 CPYFKWMGK--SFQRLGAIHCSKARRMEAFGIDYTDYVAVANYADAEGRTATHSEIFRWDAKSQR 263
               ::|..|  .|.....:....||..|||.|:...::||||:....|.....|.:::|:..::.
Zfish   413 ---YRWSNKRLKFVPYQTLETHSARDWEAFQINNEAFLAVANHRTENGNHNIESVVYKWNPGTKT 474

  Fly   264 FQLFQRLRSNGAVDVKYFSLPVNEVSRRHFLILGNTIGGTGAEVGDADTVIYVFEKGQFVPYQRL 328
            |::.|.:.::||.|.::|:     |...|||.:.|...||..:   .|:.||::..|.|..:|.:
Zfish   475 FEVNQTILTSGAYDWEFFT-----VGPYHFLAVANAFDGTSTQ---TDSSIYIWLGGAFQVFQTI 531

  Fly   329 -SFYALE--------RV-LPVQ--HSISEKFLLLVACNK---------------QDVKIYNLNDW 366
             :|.|.:        || |.|.  |.:.||...|...|.               ||:..|:..||
Zfish   532 RTFGATDWEMFQIGNRVFLAVANGHMLCEKGPSLYTINSTIYELDMTTKMFLKFQDIVTYSAVDW 596

  Fly   367 RFEESKVQFTEGALSRGVARMRSYEEGDQSYLVIAN 402
            .|                     :..||:.:||:||
Zfish   597 EF---------------------FTVGDEHFLVVAN 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clos	NP_001097246.3	EPTP	263..315	CDD:281697	14/51 (27%)
tspeara	XP_698991.2	EPTP	475..520	CDD:281697	16/52 (31%)
		EPTP	525..576	CDD:281697	13/50 (26%)
		EPTP	581..627	CDD:281697	12/52 (23%)
		EPTP	632..672	CDD:281697
		LamG	68..228	CDD:304605
		EPTP	369..416	CDD:281697	15/93 (16%)
		EPTP	421..469	CDD:281697	13/47 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594803
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto39660
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15261
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4919
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.930