DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clos and tspearb

DIOPT Version :9

Sequence 1:	NP_001097246.3	Gene:	clos / 5740204	FlyBaseID:	FBgn0261016	Length:	1836	Species:	Drosophila melanogaster
Sequence 2:	XP_682770.2	Gene:	tspearb / 555223	ZFINID:	ZDB-GENE-030131-4270	Length:	666	Species:	Danio rerio

Alignment Length:	236	Identity:	65/236 - (27%)
Similarity:	110/236 - (46%)	Gaps:	35/236 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 QCPYFKWMGK--SFQRLGAIHCSKARRMEAFGIDYTDYVAVANYADAEGRTATHSEIFRWDAKSQ 262
            |...:||..|  .|.|...:....||..|||.|....::||||:...|......|.|::|:..:|
Zfish   399 QSVIYKWSSKKLKFIRYQTLITHSARDWEAFNIQDETFLAVANHRQGERNHNIDSVIYKWNQVTQ 463

  Fly   263 RFQLFQRLRSNGAVDVKYFSLPVNEVSRRHFLILGNTIGGTGAEVGDADTVIYVFEKGQFVPYQR 327
            .|::.|.:.:.||.|.::|:     |...:||::.||..|....:   |:.||::..|.|.|||.
Zfish   464 FFEVNQTIPTAGAYDWEFFA-----VGPYYFLVVANTFNGRSTVI---DSTIYIWLGGMFQPYQS 520

  Fly   328 L-SFYALERVLPVQHSISEKFLLLVACNKQDVK-----IYNLNDWRFE-----ESKVQF----TE 377
            : :|.|::..:   ..|..:..|.|| |.|.:.     :|::|...:|     ::.|:|    |.
Zfish   521 ITTFGAIDWEM---FQIENRVFLAVA-NSQMLTEEGKILYSINSTIYELSMTSQTFVRFQDIETN 581

  Fly   378 GALSRGVARMRSYEEGDQSYLVIANENMAANETNIFQPLYK 418
            .||.     ...:..||..:||:|| :...|..::...:|:
Zfish   582 SALD-----WEYFTVGDDKFLVVAN-SYDGNSYSLNSVIYR 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clos	NP_001097246.3	EPTP	263..315	CDD:281697	13/51 (25%)
tspearb	XP_682770.2	LamG	64..218	CDD:304605
		EPTP	358..406	CDD:281697	2/6 (33%)
		EPTP	411..459	CDD:281697	15/47 (32%)
		EPTP	465..510	CDD:281697	15/52 (29%)
		EPTP	514..564	CDD:281697	14/53 (26%)
		EPTP	572..617	CDD:281697	13/51 (25%)
		EPTP	622..662	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594804
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15261
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.900