Protein Alignment kmr and plekha5

DIOPT Version :10

• Sequence 1: NP_001097775.2
• Gene: kmr / 5740131
• FlyBaseID: FBgn0085412
• Length: 3090
• Species: Drosophila melanogaster
• Sequence 2: NP_001430043.1
• Gene: plekha5 / 567300
• ZFINID: ZDB-GENE-041210-25
• Length: 1385
• Species: Danio rerio
• Alignment Length: 1884
• Identity: 359/1884 - (19%)
• Similarity: 590/1884 - (31%)
• Gaps: 758/1884 - (40%)

  Fly   285 HRHKNDLQTPGSEHG------TVYIQQN-------HP----------NHVVNQACQTQISAVKPK 326
            ||...||.| |.|.|      ..:|..|       ||          ..|||:...|:....:.|
Zfish    52 HRKTPDLPT-GWEEGYTFEGARCFINHNERKVTCKHPVSGVPSQDNCIFVVNEQPATKAPEAEKK 115

  Fly   327 ATPSSEES-SSNST---------KSPSHAPLDRKKSAGSIQALKSPITKRPPSTPVTLSGWLHKQ 381
            ..|:|..| :||.|         .||:..|....|...:. ..:|...||.|:.||..:||||||
Zfish   116 ERPTSTMSEASNYTGGSDYTTHPSSPTTRPSRSSKKVHNF-GKRSNSIKRNPNAPVIKNGWLHKQ 179

  Fly   382 GSDGLKVWRKRWFVLAEYCLYYYKGPEEEKLLGSVLLPSYRVSACLPEDKIYRKFAFKCEHQNMR 446
            .|.|:|:|:||||||::.||:||:..:||.:|||:||||:.:|....:|.|.||:|||..|.|||
Zfish   180 DSTGMKMWKKRWFVLSDMCLFYYRDEKEEGILGSILLPSFHISMLSVDDHITRKYAFKATHPNMR 244

  Fly   447 TYWLAADNSEAMMQWVRALAAASLMQAPSSGESEP---------------SVNSSLNH------S 490
            ||:.:.|.::.|..|::.::.|::      ..|||               .:|:.|||      .
Zfish   245 TYYFSTDTAKDMESWMKVMSDAAM------AHSEPIRRLEKVKLDSRVPQEMNNMLNHRVLTRPE 303

  Fly   491 GENSDSGIHTLQSHPGKGQPTPSSENTGSSGGGSGSGQPLYANAPPKPRRINDGGYSSPSPEHNE 555
            .:|::....||:....|.:|:                        .||::..|
Zfish   304 IQNNERNRETLRQEDKKSKPS------------------------EKPQKDKD------------ 332

  Fly   556 QQQQHPSRRLMSPTQQLYQQQQHQRSQQQQQQQPQQHHAIYDTRTGHVSTALQLQQAQQQYSLDH 620
                           ::..|:..:|..:.           |..|          |:..::|.|
Zfish   333 ---------------RVSMQKDGERFSEN-----------YTHR----------QKDGERYML-- 359

  Fly   621 LEAQFQQQQLDMEEQIARLQQQRAAEEIYGEREMYMAKLMQQRQG------PNGTYPTQQQLLQA 679
                    |.|:|:.:.:...::.|.:..|:      |.:.|:.|      .:|...|.|:.|:.
Zfish   360 --------QKDLEKFVLQKDGEKYAVQKEGD------KYLLQKDGHKYTVHKDGDKYTLQRELEM 410

  Fly   680 ERRTPDAYGRSKQQRLFAAAAAAADYEDIYNMSQLAGGGGVPMSAQEALLQEAASYRRPLSPPSY 744
            .....||....::...|:..           ..:|......|.|.::...|:..:..|||:.
Zfish   411 YNPPKDAEKIPQKDARFSLV-----------QKELEKPVPPPRSEEKYGFQKEGTIERPLTK--- 461

  Fly   745 DGSKHVPAMPQRYTPNHLEASAADQLINTMDLRARTAAAIVRPHSADFLEYEARAEAAAAAAAAA 809
                                      ||::.|:                      .|.|||.|||
Zfish   462 --------------------------INSIKLQ----------------------PAQAAAIAAA 478

  Fly   810 VAQSQQESGRAPRPKSSLDINRTPDSFYYSEASYADKMRKSALYLQSGGAG-AAQPQQPGSYRTT 873
            |:.|:.                               |:|     |..|:| .|..:.||...|.
Zfish   479 VSSSRM-------------------------------MQK-----QVNGSGERAGDRSPGDLSTV 507

  Fly   874 GADFNSGVNTIGYENPYERAYKRQELLAEAQGGGASSMPRMSRSASQGRSVASQLQSPQQEDLPP 938
                                              .:|:|..::.|.:.....|:..|.||
Zfish   508 ----------------------------------RTSVPPPTQPAPEPERSLSRTSSMQQ----- 533

  Fly   939 LNVHPGSIFPPSMSTQEIISKNEQFLRSASARLPKRSGGMDDDYSAGNSTTTSPTGGAGASNSPQ 1003
                                 .||::|:...|.|      |||..:..|..|.|      .|.|.
Zfish   534 ---------------------LEQWVRTHRTRAP------DDDTRSITSYQTLP------RNMPS 565

  Fly  1004 HNL-------DGERK----------------------------------REESMKRLLEWKQRML 1027
            |..       :|.|.                                  |:::|.:|.||:||..
Zfish   566 HRAQIVPRYPEGYRTLPRNMLRPDSICSVAGSVYDRALQPSTQEKRRSIRDDTMWQLYEWQQRQA 630

  Fly  1028 QSPLTRKGIQQGGSNMSAMSKLGSNPNILLASTAVASGARYAPQAGKTVLVGNGNGTAQGAGNPP 1092
            .|.|       |...:.:...:|.          :|.....:|..|.  |.|....:.....||.
Zfish   631 HSRL-------GYGTLPSPKTMGQ----------IAESIPTSPSHGS--LAGYHTFSPNRPLNPD 676

  Fly  1093 SASGIQRSRSESQANVGPGGVVYNNYSSDDEAGTVDDD-----NLYSATAGRSSSSKTTTKATTS 1152
                   ||||..:.|..|.|            |::..     :.||..|.|.:
Zfish   677 -------SRSELSSPVFRGDV------------TIERRHRPHLSKYSYPAERRA----------- 711

  Fly  1153 QAIVATTTAALAITNLGSSKNLETPNQTETEATPSSSSTASSTKAKFQLKPILKVHEASKTRIIQ 1217
                                           |.|:.:.||.|
Zfish   712 -------------------------------APPAQNITAQS----------------------- 722

  Fly  1218 VQPKHLEERPKLRLQLPKAMGNEEEQKQEDEEQENVEAEPVPILPKKTAPKSPQNANYVPVYNNK 1282
            :|.|..||...|.::|      ..:|.:.:..:|:..|:.:.:....|.|||       .:.::.
Zfish   723 LQGKTPEELTLLLIKL------RRQQAELNSLREHTLAQLMQLNLDATNPKS-------EILSHH 774

  Fly  1283 LVSNYENMEFGKPIPESKIPHSNAAITDPEETPMLMQLKLFKEQ---QDQQKQQQENEEEDLTPT 1344
            |..|...:       :|::         .|..|::..:....|.   :.|..|||.:.||....|
Zfish   775 LQRNLMYL-------DSQM---------KENEPIIFMIHTMIENSAPRPQLYQQQMSPEEYRENT 823

  Fly  1345 AESKPIPGEEDMGAPKVIKDQKLESNEEEQELEDEDDSTACEEYTDDDIDEALAQDDEDEAVVEA 1409
            ...:|                        :||               |:|..|::..|.:.||.
Zfish   824 YMYRP------------------------EEL---------------DVDAKLSRLCEQDKVVR- 848

  Fly  1410 VESQELAEERELQQIYVNEPITPTDQQFDESHYLPMTPKKVELGQPGVLTLVSATYAEEEEENHY 1474
                  .:|.:|||::            .|.|.|.             ..|:||:...|....:.
Zfish   849 ------TQEEKLQQLH------------REKHTLE-------------TALLSASQEIEMSSENP 882

  Fly  1475 VEMTKGIQDEDCRSNYEIMCLASTSSSAFKVTTKTEPVYMELAGVKASSAVPATEEAHCSSGRST 1539
            ..:...:|..|...:    .|.||.....:|:|:.|..:.|...::|...:..|         :.
Zfish   883 AAVQSVVQQRDVLQS----GLLSTCRELSRVSTELERSWREYDRLEADVTLAKT---------NL 934

  Fly  1540 LKKCKKSGTETLKKKTKKRQGKDMPDILKPAKSALALASDSSDADDESSRQQLEAKKLRSRSRFS 1604
            |::.:..|:               |....|::..:.:..:.....|     .:||.......|
Zfish   935 LEQLEALGS---------------PQTEPPSQKHVQIQKELWRIQD-----VMEALSKNKPKR-- 977

  Fly  1605 LSDTFRPASYYLGAS--TPLNNYAESSDSEILPP-PPIPAS------PPPM-------------- 1646
                 .|...:.||:  :.|:...:|.||..:|| ||:|.|      |||:
Zfish   978 -----NPEPSFPGANPLSTLHKSEDSVDSSCVPPRPPLPYSYEGGDRPPPLPNPGQPHTTRTTPH 1037

  Fly  1647 --EELKTEE-----------IFSSE-HYDTVKRKD-SNG--KVNLSYEQLPKMHASNTSLNLPKA 1694
              |:.||.:           ::.|| ...||...| |||  |...:.|:.|.  .....:..|..
Zfish  1038 RPEDRKTAQRNGTHTGPDYRLYKSEPELTTVAEVDESNGEDKSEQTAEKEPP--GVTKGIVYPVG 1100

  Fly  1695 VPSPTLKSSRLSLPDHFTKVRMTPQRLLVPATP----PQQHHARTLSDSNYSCQLTDTSSRTSSD 1755
            |.||..||   .:|:..|.......|......|    ||......:...:...::..|.......
Zfish  1101 VVSPRTKS---PMPESSTIASYVTLRKTKKPDPRTCQPQDRPRSAVEQMSSGAEVGRTRMSVEEQ 1162

  Fly  1756 LDLYRRRGQ---QQRCTSNNSL---------------------PLSSENESVEFRQRSDSELDRQ 1796
            ::..||..|   ::|...:.||                     |:.|.:|..|.|..:..|.|.:
Zfish  1163 MERIRRHQQGALRERRREDGSLSRSLSFTKDSTYYTLQARKKSPVISPDEQDERRDMTPVERDTK 1227

  Fly  1797 RSRRPLSQESISEIESLSEQFEETLSSHELDTYLSHLHLS-----TGQATPTSHLLN-------- 1848
            .::.|.::|:..:.       :|.|.:|      :||.:.     |...:....||.
Zfish  1228 HTKHPDAEENCRDT-------KEQLPAH------THLEIKDKASVTRSVSMKESLLKSVSPKPVL 1279

  Fly  1849 -----------DANAAAGADILTNLIKPPKTFRNAEDEEQHFYGNIHFLSSTDSIQQLGEAGATA 1902
                       |...|....:.|.::....|..:.||||:         ...||:||..:    :
Zfish  1280 KQDESECKLEYDRKLATQNSLQTAVMVRVGTEEDEEDEEE---------EQKDSVQQQED----S 1331

  Fly  1903 LRIIHSRNNSNISTQ------SAPYYYSELPAPPPLNNQRDIHAHGLNIAHIHNPIDRHQFNVD 1960
            ..:.:|::::.||..      |:|...|:..:.|.|:          .:.:.:....|.|||.|
Zfish  1332 YELSNSKHSTLISASCDRKNTSSPSSSSDWKSRPLLH----------QLPNTNTTASRPQFNSD 1385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kmr	NP_001097775.2	PH_PEPP1_2_3	366..469	CDD:270068	50/102 (49%)
plekha5	NP_001430043.1	None