DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SALL4 and CG4854

DIOPT Version :9

Sequence 1:	NP_065169.1	Gene:	SALL4 / 57167	HGNCID:	15924	Length:	1053	Species:	Homo sapiens
Sequence 2:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	72/329 - (21%)
Similarity:	125/329 - (37%)	Gaps:	89/329 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   365 NISAVDVK-------PKDEAAL-----YKHKCKYCSKVFGTDS---------SLQIHLRSHTGER 408
            |:.:.|:|       ||||:.:     :..|.|.|:.|..::|         |..:.||:....|
  Fly     4 NVDSRDLKCRICLVQPKDESLMPTEPDFPDKIKRCTGVELSESPDWPNRICTSCALLLRAALKLR 68

Human   409 PFVCSVCGHRFTTKGNLK-----------VHFHRHPQVKANPQLFAEFQDKVAAGNGIPYALSVP 462
                |:|..   |:.:||           ||..:..:.|...:..:: .:...:.:.:.|
  Fly    69 ----SLCQQ---TEKDLKEQKLQEINIEIVHDEQETKKKTESRDLSK-NEATGSDSELEY----- 120

Human   463 DPIDEPSLSLDSKP---------VLVTTSVGLPQNLSSGTNPKDLTGGSLPGDLQPGPSPESEGG 518
            :.:|...::|:|..         |.:..::..|:......:||.:|.             |.|
  Fly   121 EYLDSYDVTLESSEDVACSADELVSIEPAISAPEESVYSLSPKPVTF-------------EDE-- 170

Human   519 PTLPGVGPNYNSPRAGGFQGSGTPEPGSETLKL--QQLVENIDKATTDPNECLICHRVLSCQSSL 581
                      :|.:|..|..:......||.:||  ...|.:..|    |:||.|||:.......|
  Fly   171 ----------DSGQAASFTCNICNNVYSERVKLTNHMKVHSAKK----PHECEICHKRFRQTPQL 221

Human   582 KMHYRTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIR 646
            ..|..||||.||::|..|...|:.......|..:| ||   :..:.|..|.:.|..:.:|:.|::
  Fly   222 ARHMNTHTGNRPYKCDYCDSRFADPSTRIKHQRIH-TN---ERPYKCEFCSRSFGYSNVLRVHLK 282

Human   647 MHMG 650
            .|.|
  Fly   283 THTG 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SALL4	NP_065169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..149
		zf-C2H2	382..404	CDD:306579	8/30 (27%)
		C2H2 Zn finger	384..404	CDD:275368	7/28 (25%)
		zf-H2C2_2	396..421	CDD:316026	6/24 (25%)
		C2H2 Zn finger	412..432	CDD:275368	7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..546		9/62 (15%)
		C2H2 Zn finger	568..588	CDD:275368	6/19 (32%)
		zf-H2C2_2	580..605	CDD:316026	11/24 (46%)
		C2H2 Zn finger	596..619	CDD:275368	5/22 (23%)
		zf-C2H2	626..648	CDD:306579	5/21 (24%)
		C2H2 Zn finger	628..648	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..714
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..776
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	788..828
		C2H2 Zn finger	872..892	CDD:275368
		zf-C2H2	872..892	CDD:306579
		zf-H2C2_2	884..909	CDD:316026
		C2H2 Zn finger	900..920	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1039
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	9/44 (20%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		zf-H2C2_2	193..217	CDD:290200	9/27 (33%)
		COG5048	201..>258	CDD:227381	20/61 (33%)
		C2H2 Zn finger	208..228	CDD:275368	6/19 (32%)
		zf-H2C2_2	221..244	CDD:290200	10/22 (45%)
		C2H2 Zn finger	236..256	CDD:275368	4/19 (21%)
		zf-H2C2_2	251..273	CDD:290200	7/25 (28%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		zf-H2C2_2	277..301	CDD:290200	4/10 (40%)
		C2H2 Zn finger	292..312	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910